COLFORSIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H34O7
Molecular Weight	410.5012
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

InChIKey=OHCQJHSOBUTRHG-KGGHGJDLSA-N

InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H34O7
Molecular Weight	410.5012
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1380607 | https://adisinsight.springer.com/drugs/800001302

Colforsin (NKH477) is a water-soluble forskolin derivative. NKH477, like forskolin, showed adenylate cyclase stimulant activity in guinea pig ventricular membrane but did not inhibit Na+, K(+)-ATPase or phosphodiesterase (PDE) activity. The compound was developed by a Japanese company Nippon Kayaku. Colforsin daropate, a prodrug of colforsin, is marketed in Japan for the treatment of acute heart failure under tradename Adehl.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adenylate cyclase 13 Target ID: CHEMBL2097167 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8612348	Activator 1447

PubMed

Title	Date	PubMed
Second messenger modulation of electrotonic coupling between region CA3 pyramidal cell axons in the rat hippocampus.	2001-03-02	11172925
Model of the 3-D structure of the GLUT3 glucose transporter and molecular dynamics simulation of glucose transport.	2001-03-01	11170207
Mechanisms of phospholipase C activation by the vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide type 2 receptor.	2001-03	11181537
Regulation and actions of Smad7 in the modulation of activin, inhibin, and transforming growth factor-beta signaling in anterior pituitary cells.	2001-03	11181520
Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma.	2001-03	11180971
3',5'-cyclic adenosine monophosphate regulates expression of synaptotagmin in neonatal sympathetic ganglia in vitro.	2001-03	11180155
Selective enhancement of l-type calcium currents by corticotropin in acutely isolated rat amygdala neurons.	2001-03	11179456
Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction.	2001-03	11179056
Adenosine signaling in outer medullary descending vasa recta.	2001-03	11171666
Regulation of slow wave frequency by IP(3)-sensitive calcium release in the murine small intestine.	2001-03	11171626
G-protein-coupled receptor kinase 3- and protein kinase C-mediated desensitization of the PACAP receptor type 1 in human Y-79 retinoblastoma cells.	2001-03	11166332
(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.	2001-03	11166323
Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts.	2001-02-23	11181052
Thyroid hormone activation in human vascular smooth muscle cells: expression of type II iodothyronine deiodinase.	2001-02-16	11179199
LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism.	2001-02-16	11179193
Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G(i1) and G(i3).	2001-02-16	11166929
Intracellular pathways regulating ciliary beating of rat brain ependymal cells.	2001-02-15	11179397
Regulation of neuregulin expression in the injured rat brain and cultured astrocytes.	2001-02-15	11160396
Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1.	2001-02-15	11160381
GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line.	2001-02-14	11165046
Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells.	2001-02-13	11165399
Involvement of K(ATP) channels in diethylstilbestrol-induced relaxation in rat aorta.	2001-02-09	11173069
The proteasome inhibitor MG132 promotes accumulation of the steroidogenic acute regulatory protein (StAR) and steroidogenesis.	2001-02-09	11172811
Cysteine residues in the D-galactose-H+ symport protein of Escherichia coli: effects of mutagenesis on transport, reaction with N-ethylmaleimide and antibiotic binding.	2001-02-01	11171069
Membrane depolarization mediates phosphorylation and nuclear translocation of CREB in vascular smooth muscle cells.	2001-02-01	11161711
Function of a truncated glucocorticoid receptor form at a negative glucocorticoid response element in the proopiomelanocortin gene.	2001-02	11174853
Rapid modulation of Na+/K+-ATPase activity in osmoregulatory tissues of a salmonid fish.	2001-02	11171352
The growth hormone-releasing hormone receptor: desensitisation following short-term agonist exposure.	2001-02	11169166
Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine.	2001-02	11162132
The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo.	2001-02	11161985
Differential actions of PKA and PKC in the regulation of glutamate release by group III mGluRs in the entorhinal cortex.	2001-02	11160494
Parathyroid hormone-induced up-regulation of connexin-43 messenger ribonucleic acid (mRNA) is mediated by sequences within both the promoter and the 3'untranslated region of the mRNA.	2001-02	11159864
Glucocorticoids protect against apoptosis induced by serum deprivation, cyclic adenosine 3',5'-monophosphate and p53 activation in immortalized human granulosa cells: involvement of Bcl-2.	2001-02	11159853
Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone in human granulosa-luteal cells.	2001-02	11159838
beta(2)-adrenoceptor agonists inhibit release of eosinophil-activating cytokines from human airway smooth muscle cells.	2001-02	11159726
Regulation of osteoprotegerin secretion from primary cultures of human bone marrow stromal cells.	2001-01-26	11162596
cAMP mediated upregulation of CYP2A5 in mouse hepatocytes.	2001-01-26	11162586
Relaxation of rat aorta by adenosine in diabetes with and without hypertension: role of endothelium.	2001-01-19	11166736
Inhibition of stimulated Jurkat cell adenosine 3',5'-cyclic monophosphate synthesis by the immunomodulatory compound HR325.	2001-01-15	11163337
Regulation of human neutrophil-mediated cartilage proteoglycan degradation by phosphatidylinositol-3-kinase.	2001-01	11168638
NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance.	2001-01	11168538
Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence.	2001-01	11164180
Proline transport in MDCK cells expressing a mutant regulatory subunit of cAMP-dependent protein kinase.	2001-01	11161828
G protein and cAMP-dependent protein kinase mediate amyloid beta-peptide inhibition of neuronal glucose uptake.	2001-01	11161593
Reduced neuritic outgrowth and cell adhesion in neuronal cells transfected with human alpha-synuclein.	2001-01	11161475
Relationships between lipolysis induced by various lipolytic agents and hormone-sensitive lipase in rat fat cells.	2001-01	11160373
Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress.	2001	11178103
Prostacyclin inhibits the production of MMP-9 induced by phorbol ester through protein kinase A activation, but does not affect the production of MMP-2 in Human cultured mesangial cells.	2001	11174002
Activation of 5-HT receptors that stimulate the adenylyl cyclase pathway positively regulates IGF-I in cultured craniofacial mesenchymal cells.	2001	11173928
Differential neuronal localizations and dynamics of phosphorylated and unphosphorylated type 1 inositol 1,4,5-trisphosphate receptors.	2001	11166129

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:56:18 GMT 2025` Edited by `admin` on `Mon Mar 31 17:56:18 GMT 2025`
Record UNII	1F7A44V6OU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COLFORSIN

Official Name

English

FORSKOLIN

Preferred Name

English

HL 362

Code

English

COLFORSIN [MI]

Common Name

English

NSC-375489

Code

English

HL-362

Code

English

FORSKOLIN [USP-RS]

Common Name

English

L 75 1362B

Code

English

colforsin [INN]

Common Name

English

COLFORSIN [MART.]

Common Name

English

Colforsin [WHO-DD]

Common Name

English

FORSKOLIN (CONSTITUENT OF FORSKOHLII) [DSC]

Common Name

English

COLFORSIN [USAN]

Common Name

English

NSC-357088

Code

English

FORSKOLIN [VANDF]

Common Name

English

L-751362B

Code

English

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho[2,1-b]pyran-1-one 5-acetate

Common Name

English

L-75-1362B

Code

English

Classification Tree Code System Code

DSLD

151 (Number of products:123)