Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H17N2O |
| Molecular Weight | 277.3404 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
CC1=C2C=C[N+](C)=CC2=C(C)C3=C1NC4=C3C=C(O)C=C4
InChI
InChIKey=YZQRAQOSAPWELU-UHFFFAOYSA-O
InChI=1S/C18H16N2O/c1-10-15-9-20(3)7-6-13(15)11(2)18-17(10)14-8-12(21)4-5-16(14)19-18/h4-9,21H,1-3H3/p+1
| Molecular Formula | C18H16N2O |
| Molecular Weight | 276.3324 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Elliptinium is an antineoplastic agent, which was used in the treatment of metastatic breast cancer in France under the name Celiptium. The drug is known to intercalate into DNA and inhibit topoisomerase II. Several studies have demonstrated that this molecule can be oxidized, yielding a reactive electrophilic form, which is able to bind covalently to a nucleophilic biological molecule.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Virostatic in vivo effect of elliptinium on Friend's retrovirus (a model for HIV infection). | 1990 |
|
| Anti-cryptosporidial drug activity screened with an immunosuppressed rat model. | 1991 Nov-Dec |
|
| Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model. | 1993 Mar |
|
| Inhibitors of human immunodeficiency virus integrase. | 1993 Mar 15 |
|
| Viral and immunologic follow up of 4 to 9 years of AIDS treatments by quadruple combinations of virostatics including integrase inhibitors applied in short sequences differing by drug rotation. | 2002 Jan |
|
| Characterisation and internalisation of recombinant humanised HMFG-1 antibodies against MUC1. | 2005 Nov 28 |
|
| Anticancer drugs from marine flora: an overview. | 2010 |
|
| Immunotargeting of collagenase on thrombus. | 2010 Nov 16 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:02:36 GMT 2023
by
admin
on
Fri Dec 15 16:02:36 GMT 2023
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| Record UNII |
1F1959S062
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C582
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NCI_THESAURUS |
C1968
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100000087741
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996
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C90495
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C027767
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SUB01869MIG
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1F1959S062
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42723
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58337-34-1
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
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