DIMETHOXANATE

First approved in 1958

CN(C)CCOCCOC(=O)N1C2=CC=CC=C2SC3=CC=CC=C13

InChIKey=OOVJCSPCMCAXEX-UHFFFAOYSA-N

InChI=1S/C19H22N2O3S/c1-20(2)11-12-23-13-14-24-19(22)21-15-7-3-5-9-17(15)25-18-10-6-4-8-16(18)21/h3-10H,11-14H2,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

DIMETHOXANATE is a phenothiazine, which is used as a cough suppressant.

Conditions

Condition	Modality	Targets	Highest Phase	Product
cough 2 Sources: https://books.google.ru/books?id=ihxyHbnj3qYC&pg=PA205&lpg=PA205&dq=DIMETHOXANATE+Cothera&source=bl&ots=i9SN1Rgkwa&sig=YGVHwxjjIdWwO2uKT5PBMoT1Rs4&hl=ru&sa=X&ved=0ahUKEwjqtrW5y6jbAhWlNJoKHUH3D30Q6AEIOTAE#v=onepage&q=DIMETHOXANATE%20Cothera&f=false	Primary		Approved 8583	Cothera Approved Use Unknown

Doses

Dose	Population	Adverse events
50 mg 1 times / day multiple, oral Studied dose Dose: 50 mg, 1 times / day Route: oral Route: multiple Dose: 50 mg, 1 times / day Sources: https://apps.who.int/iris/bitstream/handle/10665/39030/Codeine_1970_eng_part2.pdf?sequence=3&isAllowed=y	unhealthy Health Status: unhealthy Sources: https://apps.who.int/iris/bitstream/handle/10665/39030/Codeine_1970_eng_part2.pdf?sequence=3&isAllowed=y	Sources: https://apps.who.int/iris/bitstream/handle/10665/39030/Codeine_1970_eng_part2.pdf?sequence=3&isAllowed=y

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY556002	https://www.001chemical.com/chem/477-93-0
Alfa Chemistry	477-93-0	https://www.alfa-chemistry.com/dimethoxanate-cas-477-93-0-item-161617.htm
Ambinter	Amb22731794	http://www.ambinter.com/reference/22731794
ChemMol	49416278	http://www.chemmol.com/chemmol/49416278.html
Hairui	HR109022	http://www.hairuichem.com/en/product/477-93-0.html
iChemical	EBD42179	http://www.ichemical.com/chemicals/cas-477-93-0
Molcore	MC556002	https://www.molcore.com/product/477-93-0
OChem	11418	http://www.ocheminc.com/index.php?act=psearch&pid=477D930
Smolecule	S573909	https://www.smolecule.com/products/s573909
THE BioTek	bt-289051	https://www.thebiotek.com/product/others/bt-289051

PubMed

Title	Date	PubMed
High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents.	1989-10	2477524
High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.	1983-05	6865909
Clinical evaluation of the antitussive, dimethoxanate.	1959-11	14430450
The cough sirup as palliative therapy; a clinical evaluation of dimethoxanate.	1958-07	13559964

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:54:11 GMT 2025` Edited by `admin` on `Mon Mar 31 17:54:11 GMT 2025`
Record UNII	1E3KG5FWDB
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

DIMETHOXANATE [MI]

Preferred Name

English

DIMETHOXANATE

Official Name

English

2-(2-DIMETHYLAMINOETHOXY)ETHYL PHENOTHIAZINE-10-CARBOXYLATE

Systematic Name

English

dimethoxanate [INN]

Common Name

English

Dimethoxanate [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-ATC

R05DB28