DIMETHOXANATE

First approved in 1958

CN(C)CCOCCOC(=O)N1C2=C(SC3=C1C=CC=C3)C=CC=C2

InChIKey=OOVJCSPCMCAXEX-UHFFFAOYSA-N

InChI=1S/C19H22N2O3S/c1-20(2)11-12-23-13-14-24-19(22)21-15-7-3-5-9-17(15)25-18-10-6-4-8-16(18)21/h3-10H,11-14H2,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

DIMETHOXANATE is a phenothiazine, which is used as a cough suppressant.

Conditions

Condition	Modality	Targets	Highest Phase	Product
cough 2 Sources: https://books.google.ru/books?id=ihxyHbnj3qYC&pg=PA205&lpg=PA205&dq=DIMETHOXANATE+Cothera&source=bl&ots=i9SN1Rgkwa&sig=YGVHwxjjIdWwO2uKT5PBMoT1Rs4&hl=ru&sa=X&ved=0ahUKEwjqtrW5y6jbAhWlNJoKHUH3D30Q6AEIOTAE#v=onepage&q=DIMETHOXANATE%20Cothera&f=false	Primary		Approved 8429	Cothera Approved Use Unknown

Doses

Dose	Population	Adverse events
50 mg 1 times / day multiple, oral Studied dose Dose: 50 mg, 1 times / day Route: oral Route: multiple Dose: 50 mg, 1 times / day Sources: https://apps.who.int/iris/bitstream/handle/10665/39030/Codeine_1970_eng_part2.pdf?sequence=3&isAllowed=y Page: p.200	unhealthy n = 15 Health Status: unhealthy Condition: Cough Population Size: 15 Sources: https://apps.who.int/iris/bitstream/handle/10665/39030/Codeine_1970_eng_part2.pdf?sequence=3&isAllowed=y Page: p.200	Sources: https://apps.who.int/iris/bitstream/handle/10665/39030/Codeine_1970_eng_part2.pdf?sequence=3&isAllowed=y Page: p.200

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY556002	https://www.001chemical.com/chem/477-93-0
Alfa Chemistry	477-93-0	https://www.alfa-chemistry.com/dimethoxanate-cas-477-93-0-item-161617.htm
Ambinter	Amb22731794	http://www.ambinter.com/reference/22731794
ChemMol	49416278	http://www.chemmol.com/chemmol/49416278.html
Hairui	HR109022	http://www.hairuichem.com/en/product/477-93-0.html
Molcore	MC556002	https://www.molcore.com/product/477-93-0
OChem	11418	http://www.ocheminc.com/index.php?act=psearch&pid=477D930
Smolecule	S573909	https://www.smolecule.com/products/s573909
THE BioTek	bt-289051	https://www.thebiotek.com/product/others/bt-289051
iChemical	EBD42179	http://www.ichemical.com/chemicals/cas-477-93-0

PubMed

Title	Date	PubMed
The cough sirup as palliative therapy; a clinical evaluation of dimethoxanate.	1958 Jul	13559964
Clinical evaluation of the antitussive, dimethoxanate.	1959 Nov	14430450
High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.	1983 May	6865909
High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents.	1989 Oct	2477524

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:19:47 UTC 2023` Edited by `admin` on `Fri Dec 15 15:19:47 UTC 2023`
Record UNII	1E3KG5FWDB
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

DIMETHOXANATE

Official Name

English

2-(2-DIMETHYLAMINOETHOXY)ETHYL PHENOTHIAZINE-10-CARBOXYLATE

Systematic Name

English

DIMETHOXANATE [MI]

Common Name

English

dimethoxanate [INN]

Common Name

English

Dimethoxanate [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-ATC

R05DB28