VOROZOLE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H13ClN6
Molecular Weight	324.768
Optical Activity	( + )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1N=NC2=C1C=C(C=C2)[C@@H](N3C=NC=N3)C4=CC=C(Cl)C=C4

InChI

InChIKey=XLMPPFTZALNBFS-INIZCTEOSA-N

InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3/t16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H13ClN6
Molecular Weight	324.768
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9797019 | https://www.ncbi.nlm.nih.gov/pubmed/11250606 | https://www.ncbi.nlm.nih.gov/pubmed/11844826

Vorozole is a specific, non-steroidal inhibitor of aromatase enzyme that catalyzes the last step in estrogen biosynthesis. Vorozole interferes with the aromatase heme. The drug can be useful for postmenopausal patients with advanced breast cancer.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Aromatase 8 Target ID: P11511 Gene ID: 1588.0 Gene Symbol: CYP19A1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2755126	Inhibitor 8297		3.0 nM [IC50]

PubMed

Title	Date	PubMed
Synthesis, in vivo rhesus monkey biodistribution and in vitro evaluation of a 11C-labelled potent aromatase inhibitor: [N-methyl-11C]vorozole.	1998 Jul	9720668
Aromatase inhibition blocks the expression of sexually-motivated cloacal gland movements in male quail.	2004 Nov 30	15518995
Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole.	2006 Aug	16714371

Sample Use Guides

In Vivo Use Guide

Randomization was to 12 weeks of 2.5 mg of vorozole per day orally

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:41:47 GMT 2023` Edited by `admin` on `Fri Dec 15 15:41:47 GMT 2023`
Record UNII	1E2S9YXV2A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VOROZOLE

Official Name

English

(+)-(S)-6-(P-CHLORO-A-1H-1,2,4-TRIAZOL-1-YLBENZYL)-1-METHYL-1H-BENZOTRIAZOLE

Common Name

English

R-83842

Code

English

RIVIZOR

Brand Name

English

VOROZOLE [MI]

Common Name

English

VOROZOLE [USAN]

Common Name

English

Vorozole [WHO-DD]

Common Name

English

VOROZOLE [MART.]

Common Name

English

1H-BENZOTRIAZOLE, 6-((4-CHLOROPHENYL)-1H-1,2,4-TRIAZOL-1-YLMETHYL)-1-METHYL-, (S)-

Common Name

English

vorozole [INN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

L02BG05