U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C16H13ClN6
Molecular Weight 324.768
Optical Activity ( + )
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VOROZOLE

SMILES

CN1N=NC2=C1C=C(C=C2)[C@@H](N3C=NC=N3)C4=CC=C(Cl)C=C4

InChI

InChIKey=XLMPPFTZALNBFS-INIZCTEOSA-N
InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3/t16-/m0/s1

HIDE SMILES / InChI

Molecular Formula C16H13ClN6
Molecular Weight 324.768
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Vorozole is a specific, non-steroidal inhibitor of aromatase enzyme that catalyzes the last step in estrogen biosynthesis. Vorozole interferes with the aromatase heme. The drug can be useful for postmenopausal patients with advanced breast cancer.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P11511
Gene ID: 1588.0
Gene Symbol: CYP19A1
Target Organism: Homo sapiens (Human)
3.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Synthesis, in vivo rhesus monkey biodistribution and in vitro evaluation of a 11C-labelled potent aromatase inhibitor: [N-methyl-11C]vorozole.
1998 Jul
Aromatase inhibition blocks the expression of sexually-motivated cloacal gland movements in male quail.
2004 Nov 30
Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole.
2006 Aug

Sample Use Guides

Randomization was to 12 weeks of 2.5 mg of vorozole per day orally
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:41:47 UTC 2023
Edited
by admin
on Fri Dec 15 15:41:47 UTC 2023
Record UNII
1E2S9YXV2A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VOROZOLE
INN   MART.   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
(+)-(S)-6-(P-CHLORO-A-1H-1,2,4-TRIAZOL-1-YLBENZYL)-1-METHYL-1H-BENZOTRIAZOLE
Common Name English
R-83842
Code English
RIVIZOR
Brand Name English
VOROZOLE [MI]
Common Name English
VOROZOLE [USAN]
Common Name English
Vorozole [WHO-DD]
Common Name English
VOROZOLE [MART.]
Common Name English
1H-BENZOTRIAZOLE, 6-((4-CHLOROPHENYL)-1H-1,2,4-TRIAZOL-1-YLMETHYL)-1-METHYL-, (S)-
Common Name English
vorozole [INN]
Common Name English
Classification Tree Code System Code
WHO-ATC L02BG05
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
WHO-VATC QL02BG05
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
NCI_THESAURUS C2018
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C1601
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
WIKIPEDIA
Vorozole
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
MESH
C060523
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
FDA UNII
1E2S9YXV2A
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
ChEMBL
CHEMBL224060
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
MERCK INDEX
m11503
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY Merck Index
SMS_ID
100000079327
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
PUBCHEM
6918191
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
DRUG BANK
DB13767
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
EPA CompTox
DTXSID20156230
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
CAS
129731-10-8
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
INN
6477
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
USAN
FF-45
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
EVMPD
SUB00088MIG
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
DRUG CENTRAL
3651
Created by admin on Fri Dec 15 15:41:47 UTC 2023 , Edited by admin on Fri Dec 15 15:41:47 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY