Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H20Br2N2O3 |
| Molecular Weight | 484.182 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)OC[C@H](NC(=O)NC2=CC=C(Br)C=C2Br)[C@@H](O1)C3=CC=CC=C3
InChI
InChIKey=RBKIJGLHFFQHBE-IRXDYDNUSA-N
InChI=1S/C19H20Br2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1
| Molecular Formula | C19H20Br2N2O3 |
| Molecular Weight | 484.182 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21181123 |
https://www.ncbi.nlm.nih.gov/pubmed/17638707 |
https://www.ncbi.nlm.nih.gov/pubmed/24592208 |
https://www.ncbi.nlm.nih.gov/pubmed/19363060 | https://www.ncbi.nlm.nih.gov/pubmed/17638707
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21181123 |
https://www.ncbi.nlm.nih.gov/pubmed/17638707 |
https://www.ncbi.nlm.nih.gov/pubmed/24592208 |
https://www.ncbi.nlm.nih.gov/pubmed/19363060 | https://www.ncbi.nlm.nih.gov/pubmed/17638707
JNJ-10397049 is a potent and selective antagonist of the orexin-2 receptor. JNJ-10397049 regulated ovulation, and sleep promotion. JNJ-10397049 was reported to be effective in reducing the reinforcing effects of ethanol.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. | 2007 Oct |
|
| Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement. | 2011 May |
|
| Effects of orexins A and B on expression of orexin receptors and progesterone release in luteal and granulosa ovarian cells. | 2012 Oct 10 |
|
| Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism. | 2014 |
Patents
Sample Use Guides
JNJ-10397049 (1, 3, and 10 mg/kg, sc) dose-dependently reduced ethanol self-administration without changing saccharin self-administration, dopamine levels, or withdrawal signs in rats. Treatment with JNJ-10397049 (10 mg/kg, sc) attenuated the acquisition, expression, and reinstatement of ethanol conditioned place preference and ethanol-induced hyperactivity in mice.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:36:14 GMT 2023
by
admin
on
Sat Dec 16 08:36:14 GMT 2023
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| Record UNII |
1B419P24AV
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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708275-58-5
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DTXSID501336831
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JNJ-10397049
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1B419P24AV
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9869934
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admin on Sat Dec 16 08:36:14 GMT 2023 , Edited by admin on Sat Dec 16 08:36:14 GMT 2023
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