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Details

Stereochemistry ACHIRAL
Molecular Formula C15H17O3S.Na
Molecular Weight 300.348
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM GUALENATE

SMILES

[Na+].CC(C)C1=CC=C(C)C2=C(C=C(C)C2=C1)S([O-])(=O)=O

InChI

InChIKey=GEYJUFBPCGDENK-UHFFFAOYSA-M
InChI=1S/C15H18O3S.Na/c1-9(2)12-6-5-10(3)15-13(8-12)11(4)7-14(15)19(16,17)18;/h5-9H,1-4H3,(H,16,17,18);/q;+1/p-1

HIDE SMILES / InChI
Molecular Formula C15H17O3S
Molecular Weight 277.359
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://aksci.com/item_detail.php?cat=R239 http://www.ncbi.nlm.nih.gov/pubmed/15667596

Sodium gualenate (Azunol ST Tablets) is a water-soluble derivative of azulene, a natural product which is an antiinflammatory component of chamomile of the family of Asteraceae. Sodium gualenate was originally studied as an antiulcer agent, is primary indicated in conditions like Duodenal ulcer, Gastric ulcer, Gastritis, but it is also clinically used as a therapeutic agent in the treatment of inflammation of the mouth and throat, for example, pharyngitis as well as other inflammatory diseases such as tonsillitis, stomatitis and conjunctivitis. Although the mechanism by which sodium azulene sulfonate inhibited the capsaicin-induced pharyngitis is not yet unraveled, antioxidative effect, but not inhibitory effect on cyclooxygenase pathway, might be involved.

Approval Year

2023
455
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Approved
8429
Unknown

Approved Use

Unknown
Primary
Approved
8429
Unknown

Approved Use

Unknown
Primary
Approved
8429
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Preventive effects of oren-gedoku-to on mucositis caused by anticancer agents in patients with acute leukemia].
2003 Sep
The molecular immunology of mucositis: implications for evidence-based research in alternative and complementary palliative treatments.
2005 Dec
Patents

Patents

JPS51125713A
3

Sample Use Guides

In Vivo Use Guide
Put 1 tablet (5 mg of the active ingredient) between either of right or left upper lip and gum at a time, four times daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:51:44 GMT 2023
Edited
by admin
on Fri Dec 15 15:51:44 GMT 2023
Record UNII
19WSH095WP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM GUALENATE
INN   MART.   WHO-DD  
INN  
Official Name English
SODIUM 3-METHYL-5-ISOPROPYL-8-METHYLAZULENESULPHONATE
Systematic Name English
GUAIAZULENE 3-SULPHONATE SODIUM SALT
Common Name English
AZULENE SN
Common Name English
SODIUM 5-ISOPROPYL-3,8-DIMETHYL-1-AZULENESULFONATE
Systematic Name English
SODIUM 1,4-DIMETHYL-7-ISOPROPYLAZULENE-3-SULPHONATE
Systematic Name English
sodium gualenate [INN]
Common Name English
1-AZULENESULFONIC ACID, 3,8-DIMETHYL-5-(1-METHYLETHYL)-, SODIUM SALT (1:1)
Common Name English
SODIUM GUAIAZULENE SULFONATE
INCI  
INCI  
Official Name English
SODIUM GUAIAZULENE-3-SULPHONATE
Common Name English
GUAIAZULENE 3-SULFONATE SODIUM SALT [MI]
Common Name English
GUAIAZULENE SOLUBLE
Common Name English
SODIUM 7-ISOPROPYL-1,4-DIMETHYLAZULENE-3-SULPHONATE
Systematic Name English
SODIUM 1,4-DIMETHYL-7-ISOPROPYLAZULENE-3-SULFONATE
Systematic Name English
1-AZULENESULFONIC ACID, 3,8-DIMETHYL-5-(1-METHYLETHYL)-, SODIUM SALT
Common Name English
AZULENE SULFONATE SODIUM
Systematic Name English
Sodium gualenate [WHO-DD]
Common Name English
AZUNOL ST
Brand Name English
SODIUM 3-METHYL-5-ISOPROPYL-8-METHYLAZULENESULFONATE
Systematic Name English
SODIUM 5-ISOPROPYL-3,8-DIMETHYL-1-AZULENE SULFONATE
Systematic Name English
SODIUM 5-ISOPROPYL-3,8-DIMETHYL-1-AZULENE SULPHONATE
Systematic Name English
SODIUM GUAIAZULENESULPHONATE
Common Name English
SODIUM GUALENATE [MART.]
Common Name English
1-AZULENESULFONIC ACID, 5-ISOPROPYL-3,8-DIMETHYL-, SODIUM SALT
Common Name English
SODIUM 7-ISOPROPYL-1,4-DIMETHYLAZULENE-3-SULFONATE
Systematic Name English
AZULENE SULPHONATE SODIUM
Systematic Name English
SODIUM GUAIAZULENE SULFONATE [INCI]
Common Name English
ORISTAR SGS
Brand Name English
GUAIAZULENE 3-SULFONATE SODIUM SALT
MI  
Common Name English
SODIUM 5-ISOPROPYL-3,8-DIMETHYL-1-AZULENESULPHONATE
Systematic Name English
SODIUM GUAIAZULENE-3-SULFONATE
Common Name English
SODIUM GUAIAZULENESULFONATE
Common Name English
SOLUBLE GUAIAZULENE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29701
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
Code System Code Type Description
PUBCHEM
23669592
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
INN
1630
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
EVMPD
SUB12973MIG
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
NCI_THESAURUS
C73822
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
ChEMBL
CHEMBL1852533
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
ECHA (EC/EINECS)
228-309-8
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
SMS_ID
100000077643
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
FDA UNII
19WSH095WP
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
EPA CompTox
DTXSID40211279
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
CAS
6223-35-4
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
DRUG CENTRAL
3874
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
MESH
C035058
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY
MERCK INDEX
m5860
Created by admin on Fri Dec 15 15:51:44 GMT 2023 , Edited by admin on Fri Dec 15 15:51:44 GMT 2023
PRIMARY Merck Index
Related Record Type Details
Structure of SODIUM GUALENATE MONOHYDRATE
SALT/SOLVATE -> PARENT
Structure of GUALENIC ACID
PARENT -> SALT/SOLVATE
Structure of SODIUM GUALENATE MONOHYDRATE
SOLVATE->ANHYDROUS
Related Record Type Details
Structure of GUALENIC ACID
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
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