Details
Stereochemistry | UNKNOWN |
Molecular Formula | C23H32N4O7S |
Molecular Weight | 508.588 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)SC(NC1C(O)=O)C(NC(=O)CC2=CC=CC=C2)C(=O)NCCCC[C@H](NC=O)C(O)=O
InChI
InChIKey=TXKNSNYUJUCKMI-YUCHZMFVSA-N
InChI=1S/C23H32N4O7S/c1-23(2)18(22(33)34)27-20(35-23)17(26-16(29)12-14-8-4-3-5-9-14)19(30)24-11-7-6-10-15(21(31)32)25-13-28/h3-5,8-9,13,15,17-18,20,27H,6-7,10-12H2,1-2H3,(H,24,30)(H,25,28)(H,26,29)(H,31,32)(H,33,34)/t15-,17?,18?,20?/m0/s1
Molecular Formula | C23H32N4O7S |
Molecular Weight | 508.588 |
Charge | 0 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Libecillide is a specific monovalent penicilloyl hapten inhibitor of allergic reactions to penicillin. A depression of skin hypersensitivity to PPL and/or penicillin and penicillin derivatives sometimes persisting for weeks and months was obvious in numerous allergic patients submitted to combined libecillide-penicillin treatment. A depressing effect on antipenicillin antibody titers detected by passive hemaglutination was also manifest in some patients. The overall tolerance of libecillide in allergic patients has been very good. Nevertheless, the major obstacle to a wider general use of libecillide at the present time appears to be the occurrence of positive skin reactions to that compound in approximately 5 percent of patients allergic to penicillin.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:45:19 GMT 2023
by
admin
on
Sat Dec 16 17:45:19 GMT 2023
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Record UNII |
19ONH7KRJ3
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Record Status |
Validated (UNII)
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Record Version |
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-
Download
Name | Type | Language | ||
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Official Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29578
Created by
admin on Sat Dec 16 17:45:19 GMT 2023 , Edited by admin on Sat Dec 16 17:45:19 GMT 2023
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Code System | Code | Type | Description | ||
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C81133
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76968192
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100000082288
Created by
admin on Sat Dec 16 17:45:19 GMT 2023 , Edited by admin on Sat Dec 16 17:45:19 GMT 2023
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3421
Created by
admin on Sat Dec 16 17:45:19 GMT 2023 , Edited by admin on Sat Dec 16 17:45:19 GMT 2023
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CHEMBL2104809
Created by
admin on Sat Dec 16 17:45:19 GMT 2023 , Edited by admin on Sat Dec 16 17:45:19 GMT 2023
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PRIMARY | |||
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27826-45-5
Created by
admin on Sat Dec 16 17:45:19 GMT 2023 , Edited by admin on Sat Dec 16 17:45:19 GMT 2023
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PRIMARY | |||
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DTXSID101043410
Created by
admin on Sat Dec 16 17:45:19 GMT 2023 , Edited by admin on Sat Dec 16 17:45:19 GMT 2023
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PRIMARY | |||
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19ONH7KRJ3
Created by
admin on Sat Dec 16 17:45:19 GMT 2023 , Edited by admin on Sat Dec 16 17:45:19 GMT 2023
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PRIMARY | |||
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SUB08501MIG
Created by
admin on Sat Dec 16 17:45:19 GMT 2023 , Edited by admin on Sat Dec 16 17:45:19 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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ACTIVE MOIETY |