EGUALEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H18O3S
Molecular Weight	278.367
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=CC(=C2C=C(C=CC=C12)C(C)C)S(O)(=O)=O

InChI

InChIKey=NARQSHREEUXZBT-UHFFFAOYSA-N

InChI=1S/C15H18O3S/c1-4-11-9-15(19(16,17)18)14-8-12(10(2)3)6-5-7-13(11)14/h5-10H,4H2,1-3H3,(H,16,17,18)

HIDE SMILES / InChI

Molecular Formula	C15H18O3S
Molecular Weight	278.367
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/23568973

Egualen is an azulene derivative developed for the treatment of peptic ulcer and marketed in Japan under the tradename Azuloxa. The drug exerts its antiulcer activity by antagonizing TXA2 production.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
thromboxane A2 signaling pathway 5 Target ID: GO:0038193 Sources: http://www.ncbi.nlm.nih.gov/pubmed/23568973	Antagonist 2778
gastric mucosal blood circulation 6 Target ID: GO:1990768 Sources: http://www.ncbi.nlm.nih.gov/pubmed/23568973	Activator 1430
mucus secretion 7 Target ID: GO:0070254 Sources: http://www.ncbi.nlm.nih.gov/pubmed/23568973	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gastric ulcer 67 Sources: http://www.eisai.com/news/enews201620pdf.pdf	Primary		Approved 8429	AZULOXA Approved Use Unknown

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

1 tablet (15 mg) or 0.6 g of 2.5% granules twice a day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:30:27 GMT 2023` Edited by `admin` on `Fri Dec 15 16:30:27 GMT 2023`
Record UNII	17VM9WN49U
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EGUALEN

Official Name

English

egualen [INN]

Common Name

English

Egualen [WHO-DD]

Common Name

English

3-ETHYL-7-ISOPROPYL-1-AZULENESULFONIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698