CLOPAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H20ClN3O3S
Molecular Weight	345.845
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1CCC[C@@H](C)N1NC(=O)C2=CC(=C(Cl)C=C2)S(N)(=O)=O

InChI

InChIKey=LBXHRAWDUMTPSE-AOOOYVTPSA-N

InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+

HIDE SMILES / InChI

Molecular Formula	C14H20ClN3O3S
Molecular Weight	345.845
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.healthplus24.com/drugs/clopamide.aspx

Clopamide is a thiazide diuretic which helps in removing fluid from the body. Clopamide is used in treatment of hypertension and edema.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575 Sources: http://www.healthplus24.com/drugs/clopamide.aspx	Primary		Approved 8583	BRINALDIX Approved Use Clopamide is used in treatment of hypertension and excessive fluid retention as in cardiac failure, cirrhosis, chronic renal failure, Nephrotic syndrome, Cushing’s disease.
Edema 23 Sources: http://www.healthplus24.com/drugs/clopamide.aspx	Primary		Approved 8583	BRINALDIX Approved Use Clopamide is used in treatment of hypertension and excessive fluid retention as in cardiac failure, cirrhosis, chronic renal failure, Nephrotic syndrome, Cushing’s disease.

C_max

Value	Dose	Co-administered	Analyte	Population
63 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3621784/	5 mg 0 times / UNKNOWN single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOPAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED

AUC

Value	Dose	Co-administered	Analyte	Population
543 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3621784/	5 mg 0 times / UNKNOWN single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOPAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED

T_1/2

Value	Dose	Co-administered	Analyte	Population
11.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3621784/	5 mg 0 times / UNKNOWN single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOPAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED

Doses

Dose	Population	Adverse events
80 mg single, oral Highest studied dose Dose: 80 mg Route: oral Route: single Dose: 80 mg Sources: https://pubmed.ncbi.nlm.nih.gov/5293942/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/5293942/	Other AEs: Nausea, Headache... Other AEs: Nausea Headache Sources: https://pubmed.ncbi.nlm.nih.gov/5293942/
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	Disc. AE: Hypokalaemia, Tiredness... AEs leading to discontinuation/dose reduction: Hypokalaemia (2.5%) Tiredness Dizziness Headache Palpitations Nausea Sweating Anxiety Bronchial obstruction Sleep disturbance Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/

AEs

AE	Significance	Dose	Population
Headache		80 mg single, oral Highest studied dose Dose: 80 mg Route: oral Route: single Dose: 80 mg Sources: https://pubmed.ncbi.nlm.nih.gov/5293942/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/5293942/
Nausea		80 mg single, oral Highest studied dose Dose: 80 mg Route: oral Route: single Dose: 80 mg Sources: https://pubmed.ncbi.nlm.nih.gov/5293942/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/5293942/
Hypokalaemia	2.5% Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Anxiety	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Bronchial obstruction	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Dizziness	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Headache	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Nausea	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Palpitations	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Sleep disturbance	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Sweating	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/
Tiredness	Disc. AE	5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6375710/

PubMed

Title	Date	PubMed
[Simultaneous determination of five illegal drugs in weight control foods with solid phase extraction-high performance liquid chromatography].	2010-09	21302462
Fast gas chromatographic/mass spectrometric determination of diuretics and masking agents in human urine: Development and validation of a productive screening protocol for antidoping analysis.	2006-12-01	17027009
High-speed gas chromatography in doping control: fast-GC and fast-GC/MS determination of beta-adrenoceptor ligands and diuretics.	2006-12	17305237
Influence of atypical neuroleptics on executive functioning in patients with schizophrenia: a randomized, double-blind comparison of olanzapine vs. clozapine.	2006-04	16174427
Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.	2005-08	16044110

Sample Use Guides

In Vivo Use Guide

Take clopamide on empty stomach 15 min before meals with one full glass of water.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:30:23 GMT 2025` Edited by `admin` on `Wed Apr 02 09:30:23 GMT 2025`
Record UNII	17S83WON0I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOPAMIDE

Official Name

English

AQUEX

Preferred Name

English

CLOPAMIDE [MART.]

Common Name

English

BENZAMIDE, 3-(AMINOSULFONYL)-4-CHLORO-N-(2,6-DIMETHYL-1-PIPERIDINYL)-, CIS-

Common Name

English

clopamide [INN]

Common Name

English

CLOPAMIDE [MI]

Common Name

English

CLOPAMIDE [EP MONOGRAPH]

Common Name

English

4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide

Systematic Name

English

DT-327

Code

English

Clopamide [WHO-DD]

Common Name

English

CLOPAMIDE [EP IMPURITY]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C49185