Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 14:11:18 GMT 2023
by
admin
on
Sat Dec 16 14:11:18 GMT 2023
|
| Protein Type | CYTOKINE |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
17I3DH51XQ
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
17I3DH51XQ
Created by
admin on Sat Dec 16 14:11:19 GMT 2023 , Edited by admin on Sat Dec 16 14:11:19 GMT 2023
|
PRIMARY | |||
|
P13500
Created by
admin on Sat Dec 16 14:11:19 GMT 2023 , Edited by admin on Sat Dec 16 14:11:19 GMT 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_12 | 1_52 |
| 1_11 | 1_36 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_14 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR OF EXPRESSION->TARGET |
Inhibit conversion of N-terminal Q to pE. formation of pE was prevented by inhibiting isoQC, CCL2 was more prone to N-terminal degradation, which resulted in less functional CCL2 activity. This had the net effect of decreasing monocyte infiltration in vivo, resulting in decreased lung inflammation,
IN-VIVO
|
||
|
|
INHIBITOR -> TARGET | |||
|
INHIBITOR OF EXPRESSION->TARGET |
|
||
|
INHIBITOR -> TARGET |
Inhibit conversion of N-terminal Q to pE. formation of pE was prevented by inhibiting isoQC, CCL2 was more prone to N-terminal degradation, which resulted in less functional CCL2 activity. This had the net effect of decreasing monocyte infiltration in vivo, resulting in decreased lung inflammation.
IN-VITRO
|
||
|
INHIBITOR OF EXPRESSION->TARGET |
|
||
|
INHIBITOR -> TARGET |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|
||||
| Molecular Formula | CHEMICAL |
|