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Details

Stereochemistry MIXED
Molecular Formula C17H22I3N3O8
Molecular Weight 777.0853
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOMEPROL

SMILES

CN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I

InChI

InChIKey=NJKDOADNQSYQEV-UHFFFAOYSA-N
InChI=1S/C17H22I3N3O8/c1-23(9(29)6-26)15-13(19)10(16(30)21-2-7(27)4-24)12(18)11(14(15)20)17(31)22-3-8(28)5-25/h7-8,24-28H,2-6H2,1H3,(H,21,30)(H,22,31)

HIDE SMILES / InChI

Molecular Formula C17H22I3N3O8
Molecular Weight 777.0853
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description is created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/10852647

Iomeprol is a nonionic, monomeric iodinated contrast medium. Iomeprol helps optimize images obtained with sophisticated multidetector computed tomography (MDCT) technology, especially for neurological, brain, liver, cardiac and vascular scanning. The mechanism of action of Iomeprol is as a X-Ray Contrast Activity. Launched by the Bracco Group in 1995, Iomeprol (Iomeron) currently is registered in more than 40 countries worldwide, including all major European markets, Japan, and major Middle East and Asian Pacific countries.

CNS Activity

Curator's Comment: Iomeprol penetrates into the brain of dogs

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Iomeprol

Approved Use

For cerebral angiography

Launch Date

7.2394559E11
Diagnostic
Iomeprol

Approved Use

For intravenous urography

Launch Date

7.2394559E11
Diagnostic
Iomeprol

Approved Use

For Angiocardiography

Launch Date

7.2394559E11
PubMed

PubMed

TitleDatePubMed
Antegrade MDCT pyelography for the evaluation of patients with obstructed urinary tract.
2004 Dec
[Intrathyroidal iodine concentration after application of non-ionic contrast media with and without prophylactic application of perchlorate].
2005
Intravenous contrast material administration at helical 16-detector row CT coronary angiography: effect of iodine concentration on vascular attenuation.
2005 Aug
Irradiation in presence of iodinated contrast agent results in radiosensitization of endothelial cells: consequences for computed tomography therapy.
2005 Aug 1
Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry.
2005 Aug 26
Multiphase contrast-enhanced CT of the liver with a multislice CT scanner: effects of iodine concentration and delivery rate.
2005 Feb
Incidental detection of pulmonary emboli on routine MDCT of the chest.
2005 Jan
Three-dimensional rotational angiography of the carotid arteries with high-flow injection from the aortic arch. Preliminary experience.
2005 Jan-Feb
Photocatalytic degradation of carbamazepine, clofibric acid and iomeprol with P25 and Hombikat UV100 in the presence of natural organic matter (NOM) and other organic water constituents.
2005 Jan-Feb
Influence of intracoronary attenuation on coronary plaque measurements using multislice computed tomography: observations in an ex vivo model of coronary computed tomography angiography.
2005 Jul
MDCT angiography of the pulmonary arteries: influence of iodine flow concentration on vessel attenuation and visualization.
2005 Jun
Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro.
2005 Jun
Congenital anomalies of the coronary arteries: imaging with contrast-enhanced, multidetector computed tomography.
2005 Jun
Image assessment with multislice CT coronary angiography.
2005 Mar
Cross-flow microfiltration with periodical back-washing for photocatalytic degradation of pharmaceutical and diagnostic residues-evaluation of the long-term stability of the photocatalytic activity of TiO2.
2005 Mar
Does iodine concentration affect the diagnostic efficacy of biphasic spiral CT in patients with hepatocellular carcinoma?
2005 May-Jun
[16-row multidetector CT angiography of the aortoiliac system and lower extremity arteries: contrast enhancement and image quality using a standarized examination protocol].
2005 Nov
Solitary pulmonary nodule: characterization with combined wash-in and washout features at dynamic multi-detector row CT.
2005 Nov
Demonstration of cardiac involvement of sarcoidosis by contrast-enhanced multislice computed tomography and delayed-enhanced magnetic resonance imaging.
2005 Nov-Dec
Influence of increasing convolution kernel filtering on plaque imaging with multislice CT using an ex-vivo model of coronary angiography.
2005 Sep
A 16-slice multidetector computed tomography protocol for evaluation of the gastroepiploic artery grafts in patients after coronary artery bypass surgery.
2005 Sep
High-concentration contrast media in multiphasic abdominal multidetector-row computed tomography: effect of increased iodine flow rate on parenchymal and vascular enhancement.
2005 Sep-Oct
Repeated digital substraction angiography after perimesencephalic subarachnoid hemorrhage?
2006 Apr
[Extravasation of contrast medium after coronary angiography simulates subarachnoid hemorrhage].
2006 Apr
Follow-up of intracranial aneurysms selectively treated with coils: Prospective evaluation of contrast-enhanced MR angiography.
2006 Apr
Multidetector CT in abdominal aortic aneurysm treated with endovascular repair: are unenhanced and delayed phase enhanced images effective for endoleak detection?
2006 Dec
Effects of iodinated contrast media on common carotid and brachial artery blood flow and wall shear stress.
2006 Dec
16-MDCT aortography with a low-dose contrast material protocol.
2006 Feb
3D CT protocol in the assessment of the esophageal neoplastic lesions: can it improve TNM staging?
2006 Feb
Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.
2006 Feb 1
Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: comparison with contrast-enhanced magnetic resonance.
2006 Feb 14
Low-dose multidetector-row CT angiography of the infra-renal aorta and lower extremity vessels: image quality and diagnostic accuracy in comparison with standard DSA.
2006 Jan
Hemodynamic effects of monomeric nonionic contrast media in pulmonary angiography in chronic thromboembolic pulmonary hypertension.
2006 Jul
Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCT.
2006 Jul
Multislice computed tomography and magnetic resonance imaging for the assessment of reperfused acute myocardial infarction.
2006 Jul 4
Prophylaxis of contrast material-induced nephropathy in patients in intensive care: acetylcysteine, theophylline, or both? A randomized study.
2006 Jun
Imaging of aortopulmonary collateral arteries with high-resolution multidetector CT.
2006 Jun
Multidetector CT with double arterial phase and high-iodine-concentration contrast agent in the detection of hepatocellular carcinoma.
2006 Mar
Effect of saline pushing after contrast material injection in abdominal multidetector computed tomography with the use of different iodine concentrations.
2006 Mar
Improving diagnostic accuracy of MDCT coronary angiography in patients with mild heart rhythm irregularities using ECG editing.
2006 Mar
High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400.
2006 Mar
Drug eruptions to contrast media in Japan.
2006 May
Contrast bolus optimization for cardiac 16-slice computed tomography: comparison of contrast medium formulations containing 300 and 400 milligrams of iodine per milliliter.
2006 May
Radiocontrast media cause dephosphorylation of Akt and downstream signaling targets in human renal proximal tubular cells.
2006 Nov 15
Comparison of feasibility and accuracy of transthoracic echocardiography versus computed tomography in patients with known ascending aortic aneurysm.
2006 Oct 1
Spectral coronary multidetector computed tomography angiography: dual benefit by facilitating plaque characterization and enhancing lumen depiction.
2006 Sep-Oct
Usefulness of saline pushing in reduction of contrast material dose in abdominal CT: evaluation of time-density curve for the aorta, portal vein and liver.
2007 Apr
Fixed drug eruption induced by an iodinated non-ionic X-ray contrast medium: a practical approach to identify the causative agent and to prevent its recurrence.
2007 Feb
Image quality in CT perfusion imaging of the brain. The role of iodine concentration.
2007 Jan
Extravascular incidental findings at multislice CT angiography of the abdominal aorta and lower extremity arteries: a retrospective review study.
2007 Jul-Aug
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Can also be used intravascularly https://www.medicines.org.uk/emc/medicine/15853
IOMERON 300 Injection: each mL of IOMERON contains 612.4 mg (equivalent to 300 mg of iodine) of iomeprol. Radiological examination IOMERON 300 - 5 - 15 mL Thoracic angiography IOMERON 300 5 - 50 mL Abdominal angiography IOMERON 300 - 5 - 60 mL Peripheral anogiography IOMERON 300 - 10 - 80 mL Intravenous digital subtraction angiography IOMERON 300 - 10 - 50 mL Intraarterial digital subtraction angiography IOMERON 300 - 3 - 40 mL The dosage may be adjusted depending on the patient’s age, body weight, symptoms and purpose of use. In the case of multiple-dose administration, a total dosage of 250 mL should not be exceeded.
Route of Administration: Intravenous
In Vitro Use Guide
Iomeprol induced a time- and dose-dependent inhibition of MTT conversion in LLC-PK1-cells (75%-19% of control) at concentrations ranging from 4.7 to 75 mg I/mL after an incubation time of 2 hours and 64%-14% of control after 24 hours.
Substance Class Chemical
Created
by admin
on Thu Jul 06 01:07:22 UTC 2023
Edited
by admin
on Thu Jul 06 01:07:22 UTC 2023
Record UNII
17E17JBP8L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IOMEPROL
INN   JAN   MART.   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
E-7337
Code English
N,N'-BIS(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIODO-5-(N-METHYLGLYCOLAMIDO)ISOPHTHALAMIDE
Systematic Name English
IOMEPROL [MI]
Common Name English
IOMEPROL [JAN]
Common Name English
IOMERON 300
Brand Name English
iomeprol [INN]
Common Name English
E7337
Code English
Iomeprol [WHO-DD]
Common Name English
1,3-BENZENEDICARBOXAMIDE, N,N'-BIS(2,3-DIHYDROXYPROPYL)-5-((HYDROXYACETYL)METHYLAMINO)-2,4,6-TRIIODO-
Systematic Name English
IOMEPROL [USAN]
Common Name English
IOMEPROL [MART.]
Common Name English
Classification Tree Code System Code
WHO-ATC V08AB10
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
WHO-VATC QV08AB10
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
Code System Code Type Description
LACTMED
Iomeprol
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
NCI_THESAURUS
C166471
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
FDA UNII
17E17JBP8L
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
WIKIPEDIA
Iomeprol
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
PUBCHEM
3731
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
MESH
C057937
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
DAILYMED
17E17JBP8L
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
DRUG CENTRAL
1463
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
EVMPD
SUB08234MIG
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
EPA CompTox
DTXSID1049061
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
CAS
78649-41-9
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
USAN
BB-15
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
MERCK INDEX
M6367
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY Merck Index
RXCUI
2606484
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
DRUG BANK
DB11705
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
ChEMBL
CHEMBL2107214
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
CHEBI
31710
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
SMS_ID
100000083083
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
INN
5859
Created by admin on Thu Jul 06 01:07:22 UTC 2023 , Edited by admin on Thu Jul 06 01:07:22 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY