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Details

Stereochemistry MIXED
Molecular Formula C17H22I3N3O8
Molecular Weight 777.0853
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOMEPROL

SMILES

CN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I

InChI

InChIKey=NJKDOADNQSYQEV-UHFFFAOYSA-N
InChI=1S/C17H22I3N3O8/c1-23(9(29)6-26)15-13(19)10(16(30)21-2-7(27)4-24)12(18)11(14(15)20)17(31)22-3-8(28)5-25/h7-8,24-28H,2-6H2,1H3,(H,21,30)(H,22,31)

HIDE SMILES / InChI

Molecular Formula C17H22I3N3O8
Molecular Weight 777.0853
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Iomeprol is a nonionic, monomeric iodinated contrast medium. Iomeprol helps optimize images obtained with sophisticated multidetector computed tomography (MDCT) technology, especially for neurological, brain, liver, cardiac and vascular scanning. The mechanism of action of Iomeprol is as a X-Ray Contrast Activity. Launched by the Bracco Group in 1995, Iomeprol (Iomeron) currently is registered in more than 40 countries worldwide, including all major European markets, Japan, and major Middle East and Asian Pacific countries.

CNS Activity

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Iomeprol
Diagnostic
Iomeprol
Diagnostic
Iomeprol

AUC

ValueDoseCo-administeredAnalytePopulation
7.7 mg × h/mL
40.8 g single, intravenous
IOMEPROL plasma
Homo sapiens
10.3 mg × h/mL
40.8 g single, intravenous
IOMEPROL plasma
Homo sapiens
22.1 mg × h/mL
40.8 g single, intravenous
IOMEPROL plasma
Homo sapiens
46.4 mg × h/mL
40.8 g single, intravenous
IOMEPROL plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
32.6 h
65 g single, intravenous
IOMEPROL plasma
Homo sapiens
2.34 h
40.8 g single, intravenous
IOMEPROL plasma
Homo sapiens
3.67 h
40.8 g single, intravenous
IOMEPROL plasma
Homo sapiens
6.9 h
40.8 g single, intravenous
IOMEPROL plasma
Homo sapiens
15.1 h
40.8 g single, intravenous
IOMEPROL plasma
Homo sapiens

Doses

AEs

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
IOMERON 300 Injection: each mL of IOMERON contains 612.4 mg (equivalent to 300 mg of iodine) of iomeprol. Radiological examination IOMERON 300 - 5 - 15 mL Thoracic angiography IOMERON 300 5 - 50 mL Abdominal angiography IOMERON 300 - 5 - 60 mL Peripheral anogiography IOMERON 300 - 10 - 80 mL Intravenous digital subtraction angiography IOMERON 300 - 10 - 50 mL Intraarterial digital subtraction angiography IOMERON 300 - 3 - 40 mL The dosage may be adjusted depending on the patient’s age, body weight, symptoms and purpose of use. In the case of multiple-dose administration, a total dosage of 250 mL should not be exceeded.
Route of Administration: Intravenous
In Vitro Use Guide
Iomeprol induced a time- and dose-dependent inhibition of MTT conversion in LLC-PK1-cells (75%-19% of control) at concentrations ranging from 4.7 to 75 mg I/mL after an incubation time of 2 hours and 64%-14% of control after 24 hours.
Substance Class Chemical
Record UNII
17E17JBP8L
Record Status Validated (UNII)
Record Version