IOMEPROL

Details

Stereochemistry	MIXED
Molecular Formula	C17H22I3N3O8
Molecular Weight	777.0853
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I

InChI

InChIKey=NJKDOADNQSYQEV-UHFFFAOYSA-N

InChI=1S/C17H22I3N3O8/c1-23(9(29)6-26)15-13(19)10(16(30)21-2-7(27)4-24)12(18)11(14(15)20)17(31)22-3-8(28)5-25/h7-8,24-28H,2-6H2,1H3,(H,21,30)(H,22,31)

HIDE SMILES / InChI

Molecular Formula	C17H22I3N3O8
Molecular Weight	777.0853
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://imaging.bracco.com/us-en/bracco-s-iomeron-iomeprol-contrast-agent-optimizes-multidetector-ct-images
Curator's Comment: Description is created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/10852647

Iomeprol is a nonionic, monomeric iodinated contrast medium. Iomeprol helps optimize images obtained with sophisticated multidetector computed tomography (MDCT) technology, especially for neurological, brain, liver, cardiac and vascular scanning. The mechanism of action of Iomeprol is as a X-Ray Contrast Activity. Launched by the Bracco Group in 1995, Iomeprol (Iomeron) currently is registered in more than 40 countries worldwide, including all major European markets, Japan, and major Middle East and Asian Pacific countries.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Arteriovenous malformations 2 Sources: http://www.eisai.jp/medical/products/di/EPI/IOM_V_EPI.pdf	Diagnostic	Approved 8583	Iomeprol Approved Use For cerebral angiography Launch Date 1992
Abnormalities of the urinary system, including the kidneys, ureters, and bladder 1 Sources: http://www.eisai.com/news/enews200833pdf.pdf	Diagnostic	Approved 8583	Iomeprol Approved Use For intravenous urography Launch Date 1992
Coronary artery disease 48 Sources: http://www.eisai.jp/medical/products/di/EPI/IOM_V_EPI.pdf	Diagnostic	Approved 8583	Iomeprol Approved Use For Angiocardiography Launch Date 1992

AUC

Value	Dose	Analyte	Population
7.7 mg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11410750/	40.8 g single, intravenous dose: 40.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
10.3 mg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11410750/	40.8 g single, intravenous dose: 40.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
22.1 mg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11410750/	40.8 g single, intravenous dose: 40.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
46.4 mg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11410750/	40.8 g single, intravenous dose: 40.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
32.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10507822/	65 g single, intravenous dose: 65 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.34 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11410750/	40.8 g single, intravenous dose: 40.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.67 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11410750/	40.8 g single, intravenous dose: 40.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
6.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11410750/	40.8 g single, intravenous dose: 40.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
15.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11410750/	40.8 g single, intravenous dose: 40.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IOMEPROL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
50 mL single, intravascular Recommended\|Highest studied dose Dose: 50 mL Route: intravascular Route: single Dose: 50 mL Sources: https://pubmed.ncbi.nlm.nih.gov/23347254/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23347254/	Other AEs: Hemolysis... Other AEs: Hemolysis Sources: https://pubmed.ncbi.nlm.nih.gov/23347254/

AEs

AE	Significance	Dose	Population
Hemolysis		50 mL single, intravascular Recommended\|Highest studied dose Dose: 50 mL Route: intravascular Route: single Dose: 50 mL Sources: https://pubmed.ncbi.nlm.nih.gov/23347254/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23347254/

PubMed

Title	Date	PubMed
Usefulness of saline pushing in reduction of contrast material dose in abdominal CT: evaluation of time-density curve for the aorta, portal vein and liver.	2007-04	17038409
Fixed drug eruption induced by an iodinated non-ionic X-ray contrast medium: a practical approach to identify the causative agent and to prevent its recurrence.	2007-02	16937101
Image quality in CT perfusion imaging of the brain. The role of iodine concentration.	2007-01	16703311
Multidetector CT in abdominal aortic aneurysm treated with endovascular repair: are unenhanced and delayed phase enhanced images effective for endoleak detection?	2006-12	17032909
Effects of iodinated contrast media on common carotid and brachial artery blood flow and wall shear stress.	2006-12	16733684
Radiocontrast media cause dephosphorylation of Akt and downstream signaling targets in human renal proximal tubular cells.	2006-11-15	16989777
Comparison of feasibility and accuracy of transthoracic echocardiography versus computed tomography in patients with known ascending aortic aneurysm.	2006-10-01	16996884
Extravascular incidental findings at multislice CT angiography of the abdominal aorta and lower extremity arteries: a retrospective review study.	2006-09-13	16967229
Spectral coronary multidetector computed tomography angiography: dual benefit by facilitating plaque characterization and enhancing lumen depiction.	2006-09-07	16954934
Multislice computed tomography and magnetic resonance imaging for the assessment of reperfused acute myocardial infarction.	2006-07-04	16814660
Hemodynamic effects of monomeric nonionic contrast media in pulmonary angiography in chronic thromboembolic pulmonary hypertension.	2006-07	16794166
Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCT.	2006-07	16794142
Prophylaxis of contrast material-induced nephropathy in patients in intensive care: acetylcysteine, theophylline, or both? A randomized study.	2006-06	16714461
Imaging of aortopulmonary collateral arteries with high-resolution multidetector CT.	2006-06	16555039
Drug eruptions to contrast media in Japan.	2006-05	16681576
Contrast bolus optimization for cardiac 16-slice computed tomography: comparison of contrast medium formulations containing 300 and 400 milligrams of iodine per milliliter.	2006-05	16625109
Repeated digital substraction angiography after perimesencephalic subarachnoid hemorrhage?	2006-04	16733421
[Extravasation of contrast medium after coronary angiography simulates subarachnoid hemorrhage].	2006-04	16612734
Follow-up of intracranial aneurysms selectively treated with coils: Prospective evaluation of contrast-enhanced MR angiography.	2006-04	16611757
Multidetector CT with double arterial phase and high-iodine-concentration contrast agent in the detection of hepatocellular carcinoma.	2006-03	16671376
Effect of saline pushing after contrast material injection in abdominal multidetector computed tomography with the use of different iodine concentrations.	2006-03	16604967
Improving diagnostic accuracy of MDCT coronary angiography in patients with mild heart rhythm irregularities using ECG editing.	2006-03	16498089
High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400.	2006-03	16481919
Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: comparison with contrast-enhanced magnetic resonance.	2006-02-14	16461822
Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.	2006-02-01	16338098
16-MDCT aortography with a low-dose contrast material protocol.	2006-02	16423941
3D CT protocol in the assessment of the esophageal neoplastic lesions: can it improve TNM staging?	2006-02	16041528
Low-dose multidetector-row CT angiography of the infra-renal aorta and lower extremity vessels: image quality and diagnostic accuracy in comparison with standard DSA.	2006-01	15988586
Demonstration of cardiac involvement of sarcoidosis by contrast-enhanced multislice computed tomography and delayed-enhanced magnetic resonance imaging.	2005-11-08	16272844
[16-row multidetector CT angiography of the aortoiliac system and lower extremity arteries: contrast enhancement and image quality using a standarized examination protocol].	2005-11	16302138
Solitary pulmonary nodule: characterization with combined wash-in and washout features at dynamic multi-detector row CT.	2005-11	16244276
High-concentration contrast media in multiphasic abdominal multidetector-row computed tomography: effect of increased iodine flow rate on parenchymal and vascular enhancement.	2005-09-16	16163023
Influence of increasing convolution kernel filtering on plaque imaging with multislice CT using an ex-vivo model of coronary angiography.	2005-09	16200045
A 16-slice multidetector computed tomography protocol for evaluation of the gastroepiploic artery grafts in patients after coronary artery bypass surgery.	2005-09	15906037
Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry.	2005-08-26	16106857
Irradiation in presence of iodinated contrast agent results in radiosensitization of endothelial cells: consequences for computed tomography therapy.	2005-08-01	16029811
Intravenous contrast material administration at helical 16-detector row CT coronary angiography: effect of iodine concentration on vascular attenuation.	2005-08	16040923
Influence of intracoronary attenuation on coronary plaque measurements using multislice computed tomography: observations in an ex vivo model of coronary computed tomography angiography.	2005-07	15750815
MDCT angiography of the pulmonary arteries: influence of iodine flow concentration on vessel attenuation and visualization.	2005-06	15908557
Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro.	2005-06	15845795
Congenital anomalies of the coronary arteries: imaging with contrast-enhanced, multidetector computed tomography.	2005-06	15756551
Image assessment with multislice CT coronary angiography.	2005-03	15775888
Cross-flow microfiltration with periodical back-washing for photocatalytic degradation of pharmaceutical and diagnostic residues-evaluation of the long-term stability of the photocatalytic activity of TiO2.	2005-03	15743630
Three-dimensional rotational angiography of the carotid arteries with high-flow injection from the aortic arch. Preliminary experience.	2005-02-25	15729191
Multiphase contrast-enhanced CT of the liver with a multislice CT scanner: effects of iodine concentration and delivery rate.	2005-02	15786754
Does iodine concentration affect the diagnostic efficacy of biphasic spiral CT in patients with hepatocellular carcinoma?	2005-01-18	15654576
Incidental detection of pulmonary emboli on routine MDCT of the chest.	2005-01	15615986
[Intrathyroidal iodine concentration after application of non-ionic contrast media with and without prophylactic application of perchlorate].	2005	16163410
Antegrade MDCT pyelography for the evaluation of patients with obstructed urinary tract.	2004-12	15547210
Photocatalytic degradation of carbamazepine, clofibric acid and iomeprol with P25 and Hombikat UV100 in the presence of natural organic matter (NOM) and other organic water constituents.	2004-03-29	15644249

Patents

Sample Use Guides

In Vivo Use Guide

IOMERON 300 Injection: each mL of IOMERON contains 612.4 mg (equivalent to 300 mg of iodine) of iomeprol. Radiological examination IOMERON 300 - 5 - 15 mL Thoracic angiography IOMERON 300 5 - 50 mL Abdominal angiography IOMERON 300 - 5 - 60 mL Peripheral anogiography IOMERON 300 - 10 - 80 mL Intravenous digital subtraction angiography IOMERON 300 - 10 - 50 mL Intraarterial digital subtraction angiography IOMERON 300 - 3 - 40 mL The dosage may be adjusted depending on the patient’s age, body weight, symptoms and purpose of use. In the case of multiple-dose administration, a total dosage of 250 mL should not be exceeded.

Route of Administration: Intravenous

In Vitro Use Guide

Iomeprol induced a time- and dose-dependent inhibition of MTT conversion in LLC-PK1-cells (75%-19% of control) at concentrations ranging from 4.7 to 75 mg I/mL after an incubation time of 2 hours and 64%-14% of control after 24 hours.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:54:20 GMT 2025` Edited by `admin` on `Mon Mar 31 18:54:20 GMT 2025`
Record UNII	17E17JBP8L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IOMERON 300

Preferred Name

English

IOMEPROL

Official Name

English

E-7337

Code

English

N,N'-BIS(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIODO-5-(N-METHYLGLYCOLAMIDO)ISOPHTHALAMIDE

Systematic Name

English

IOMEPROL [MI]

Common Name

English

IOMEPROL [JAN]

Common Name

English

iomeprol [INN]

Common Name

English

E7337

Code

English

IOMERVU

Brand Name

English

Iomeprol [WHO-DD]

Common Name

English

1,3-BENZENEDICARBOXAMIDE, N,N'-BIS(2,3-DIHYDROXYPROPYL)-5-((HYDROXYACETYL)METHYLAMINO)-2,4,6-TRIIODO-

Systematic Name

English

IOMEPROL [USAN]

Common Name

English

IOMEPROL [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

V08AB10