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Details

Stereochemistry UNKNOWN
Molecular Formula C37H48I6N6O18
Molecular Weight 1626.2332
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOTROLAN

SMILES

CN(C(=O)CC(=O)N(C)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I)C2=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C2I

InChI

InChIKey=XUHXFSYUBXNTHU-UHFFFAOYSA-N
InChI=1S/C37H48I6N6O18/c1-48(32-28(40)22(34(64)44-12(4-50)16(58)8-54)26(38)23(29(32)41)35(65)45-13(5-51)17(59)9-55)20(62)3-21(63)49(2)33-30(42)24(36(66)46-14(6-52)18(60)10-56)27(39)25(31(33)43)37(67)47-15(7-53)19(61)11-57/h12-19,50-61H,3-11H2,1-2H3,(H,44,64)(H,45,65)(H,46,66)(H,47,67)

HIDE SMILES / InChI
Molecular Formula C37H48I6N6O18
Molecular Weight 1626.2332
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 8
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Iotrol, a nonionic dimeric, intrathecal contrast medium for myelography. This agent does not exhibit any cytotoxic effect on human healthy nucleus pulposus (NP) cells.

Approval Year

1989
115
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8429
OSMOVIST

Approved Use

Radiculography; lumbar myelography including the medullary cone; thoracic myelography; cervical myelography; panmyelography; ventriculography; for evaluation of the fluid circulation, particularly in hydrocephalus, using computerised tomography; cisternography using computerised tomography.

Launch Date

6.2890561E11
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/2568801
5112 mg single, lumbar injection
dose: 5112 mg
route of administration: Lumbar injection
experiment type: SINGLE
co-administered:
IOTROLAN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B2-5220
http://www.3bsc.com/index/pro_info.php?id=85022
AHH Chemical co.,ltd
MT-52845
http://www.ahhchemical.com/product/MT-52845.html
AK Scientific, Inc. (AKSCI)
I663
http://www.aksci.com/item_detail.php?cat=I663
Ambinter
Amb22734513
http://www.ambinter.com/reference/22734513
BOC Sciences
79770-24-4
https://www.bocsci.com/iotrolan-isovist-cas-79770-24-4-item-210172.html
ChemMol
49422918
http://www.chemmol.com/chemmol/49422918.html
ChemMol
99148384
http://www.chemmol.com/chemmol/99148384.html
Finetech
FT-0754152
http://www.finetechnology-ind.com/prod/detail/pub/79770-24-4.html
Hairui
HR128748
http://www.hairuichem.com/en/product/79770-24-4.html
Molcore
MC572344
https://www.molcore.com/product/79770-24-4
OChem
21381
http://www.ocheminc.com/index.php?act=psearch&pid=770I244
Smolecule
S530762
http://www.smolecule.com/products/s530762
THE BioTek
bt-271809
https://www.thebiotek.com/product/inhibitors/bt-271809
PubMed

PubMed

TitleDatePubMed
Clinical trial of iotrol for lumbar myelography.
1983 May-Jun
[Iotrolan versus iopamidol. A controlled double-blind study with lumbar myelography].
1992 Aug
Neurotolerability of nonionic X-ray contrast media. The role of chemotoxicity.
1996 Jun
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:04:16 UTC 2023
Edited
by admin
on Sat Dec 16 16:04:16 UTC 2023
Record UNII
16FL47B687
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IOTROLAN
EP   INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
iotrolan [INN]
Common Name English
IOTROLAN [EP MONOGRAPH]
Common Name English
5,5'-(MALONYLBIS(METHYLIMINO))BIS(N,N'-BIS(2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL)-2,4,6-TRIIODOISOPHTHALAMIDE)
Common Name English
ZK 39 482
Code English
OSMOVIST
Brand Name English
IOTROLAN [VANDF]
Common Name English
IOTROLAN [MART.]
Common Name English
IOTROL
Common Name English
ISOVIST 300
Brand Name English
IOTROLAN [MI]
Common Name English
IOTROLAN [USAN]
Common Name English
1,3-BENZENEDICARBOXAMIDE, 5,5'-((1,3-DIOXO-1,3-PROPANEDIYL)BIS(METHYLIMINO))BIS(N,N'-BIS(2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL)-2,4,6-TRIIODO-
Common Name English
Iotrolan [WHO-DD]
Common Name English
ZK-39482
Code English
IOTROLAN [JAN]
Common Name English
ZK-39-482
Code English
IOTROLAN [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
WHO-ATC V08AB06
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
NCI_THESAURUS C28500
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
WHO-VATC QV08AB06
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID0023165
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
DRUG BANK
DB09487
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
DRUG CENTRAL
1470
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
SMS_ID
100000092065
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
EVMPD
SUB08260MIG
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
INN
5179
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
MERCK INDEX
m6378
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY Merck Index
FDA UNII
16FL47B687
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
MESH
C033300
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
ChEMBL
CHEMBL1200555
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
PUBCHEM
3738
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
RXCUI
51474
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY RxNorm
NCI_THESAURUS
C65945
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
CAS
79770-24-4
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
USAN
U-50
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
WIKIPEDIA
IOTROLAN
Created by admin on Sat Dec 16 16:04:16 UTC 2023 , Edited by admin on Sat Dec 16 16:04:16 UTC 2023
PRIMARY
Related Record Type Details
Structure of IOTROLAN
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