Details
Stereochemistry | ACHIRAL |
Molecular Formula | C11H9I3N2O4 |
Molecular Weight | 613.9136 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC(=O)C1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I
InChI
InChIKey=UXIGWFXRQKWHHA-UHFFFAOYSA-N
InChI=1S/C11H9I3N2O4/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20/h1-2H3,(H,15,18)(H,16,17)(H,19,20)
Molecular Formula | C11H9I3N2O4 |
Molecular Weight | 613.9136 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/28028385 | https://www.ncbi.nlm.nih.gov/pubmed/26573558 | https://www.ncbi.nlm.nih.gov/pubmed/18650405
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/28028385 | https://www.ncbi.nlm.nih.gov/pubmed/26573558 | https://www.ncbi.nlm.nih.gov/pubmed/18650405
Iothalamic Acid is an iodine-containing organic anion used as a radiocontrast agent. It is available as sodium iothalamate (Iothalamate sodium) and meglumine iothalamate (Iothalmate meglumine). It can be administered intravenously or intravesically (into the urinary bladder). Iothalamate is indicated to visualize specific regions of the vascular system and blood flow in these areas to help in the diagnosis and evaluation of neoplasms (known or suspected) or vascular diseases (congenital or acquired) that may cause changes in normal vascular anatomy or physiology. Iothalamate meglumine injection is indicated for use in cerebral angiography, peripheral arteriography or venography, arterial digital subtraction angiography1 , and intravenous digital subtraction angiography. Iothalamate meglumine and iothalamate sodium injection is indicated for use in selective coronary arteriography, selective renal arteriography, and in intravenous digital subtraction angiography. othalamate meglumine and iothalamate sodium injection and iothalamate sodium injection are indicated to visualize the aorta and its major branches. However, the injection of iothalamate meglumine and iothalamate sodium is preferred because it generally causes less severe hemodynamic, neurotoxic, and cardiotoxic effects than the individual injection of iothalamate sodium. Radioactive formulation is also available as sodium iothalamate I-125 Injection (GLOFIL-125). It is indicated for evaluation of glomerular filtration in the diagnosis or monitoring of patients with renal disease.
CNS Activity
Approval Year
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
64 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3230149 |
63 mmol single, intravascular dose: 63 mmol route of administration: Intravascular experiment type: SINGLE co-administered: |
IOTHALAMIC ACID serum | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
90.45% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11403171 |
IOTHALAMIC ACID plasma | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.5 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.5 |
Disc. AE: Thromboembolic event, Myocardial infarction... AEs leading to discontinuation/dose reduction: Thromboembolic event (serious) Sources: Page: p.5Myocardial infarction (serious) Stroke (serious) Paralysis |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.6 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.6 |
Disc. AE: Convulsions, Skin and subcutaneous conditions NEC... AEs leading to discontinuation/dose reduction: Convulsions Sources: Page: p.6Skin and subcutaneous conditions NEC (severe) |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.7 |
Disc. AE: Stevens-Johnson syndrome, Toxic epidermal necrolysis... AEs leading to discontinuation/dose reduction: Stevens-Johnson syndrome (severe) Sources: Page: p.7Toxic epidermal necrolysis (severe) Acute generalized exanthematous pustulosis (severe) Drug reaction with eosinophilia and systemic symptoms (severe) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Paralysis | Disc. AE | 200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.5 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.5 |
Myocardial infarction | serious Disc. AE |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.5 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.5 |
Stroke | serious Disc. AE |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.5 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.5 |
Thromboembolic event | serious Disc. AE |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.5 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.5 |
Convulsions | Disc. AE | 200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.6 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.6 |
Skin and subcutaneous conditions NEC | severe Disc. AE |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.6 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.6 |
Acute generalized exanthematous pustulosis | severe Disc. AE |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.7 |
Drug reaction with eosinophilia and systemic symptoms | severe Disc. AE |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.7 |
Stevens-Johnson syndrome | severe Disc. AE |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.7 |
Toxic epidermal necrolysis | severe Disc. AE |
200 mL single, intravenous Recommended Dose: 200 mL Route: intravenous Route: single Dose: 200 mL Sources: Page: p.7 |
unhealthy Health Status: unhealthy Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography Sources: Page: p.7 |
PubMed
Title | Date | PubMed |
---|---|---|
[Recurrent aseptic meningitis (Mollaret meningitis)--spontaneous and drug-induced origin]. | 1991 Dec |
|
Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease. | 2004 Dec 21 |
|
Summaries for patients. Estimating kidney function in healthy people. | 2004 Dec 21 |
|
Hypersensitivity to intravenous contrast material causing CT appearance of bowel wall thickening. | 2004 Jul |
|
Interferences in clinical capillary zone electrophoresis of serum proteins. | 2004 Jun |
|
Studies on experimental iodine allergy: 2. Iodinated protein antigens and their generation from inorganic and organic iodine-containing chemicals. | 2004 May |
|
Effect of contrast media on vascular smooth muscle cells. | 2004 Oct |
|
Sensitivity variation of doped Fricke gel irradiated with monochromatic synchrotron X rays between 33.5 and 80 keV. | 2005 |
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An alternative formula to the Cockcroft-Gault and the modification of diet in renal diseases formulas in predicting GFR in individuals with type 1 diabetes. | 2005 Apr |
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Performance of the Cockcroft-Gault and modification of diet in renal disease equations in estimating GFR in ill hospitalized patients. | 2005 Aug |
|
Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry. | 2005 Aug 26 |
|
Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia. | 2005 Feb |
|
Power injection of microcatheters: an in vitro comparison. | 2005 Jan |
|
Simultaneous determination of anions in nanoliter volumes. | 2005 Jan |
|
The value of contrast-enhanced helical CT scan with rectal contrast enema in the diagnosis of acute appendicitis. | 2005 Jul-Aug |
|
Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro. | 2005 Jun |
|
Telebrix Gastro in the management of adhesive small bowel obstruction. | 2005 May |
|
CT voiding cystourethrography using 16-MDCT for the evaluation of female urethral diverticula: initial experience. | 2005 May |
|
Simple HPLC-UV method for determination of iohexol, iothalamate, p-aminohippuric acid and n-acetyl-p-aminohippuric acid in human plasma and urine with ERPF, GFR and ERPF/GFR ratio determination using colorimetric analysis. | 2005 Nov 5 |
|
PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients. | 2005 Oct |
|
Virtopsy: postmortem minimally invasive angiography using cross section techniques--implementation and preliminary results. | 2005 Sep |
|
[Pancreas anulare as an incidental finding in multidetector computer tomography for symptomatic abdominal aortic aneurysm]. | 2006 Apr |
|
A novel approach to flexor hallucis longus tenography. | 2006 Dec |
|
Estimating absolute glomerular filtration rate in children. | 2006 Dec |
|
Effect on bone induction of using contrast media to reconstitute recombinant human bone morphogenetic protein-2 in an ectopic model in rats. | 2006 Nov |
|
Drawbacks and prognostic value of formulas estimating renal function in patients with chronic heart failure and systolic dysfunction. | 2006 Oct 10 |
|
Reproducibility of renal function measurements in adult men with diabetic nephropathy: research and clinical implications. | 2007 |
|
Renal handling of cystatin C. | 2007 Apr |
|
Endoscopic treatment of completely occluding anastomotic web using incision and ballooning after dye injection. | 2007 Feb |
|
Evidence that postprandial reduction of renal calcium reabsorption mediates hypercalciuria of patients with calcium nephrolithiasis. | 2007 Jan |
|
Preemptive living donor kidney transplantation: do the benefits extend to all recipients? | 2007 Jan 27 |
|
[Renal radionuclide scintigraphy in the evaluation of radiopaque substances on renal function]. | 2007 Jan-Feb |
|
Iodide mumps after contrast media imaging: a rare adverse effect to iodine. | 2007 Jul |
|
Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database. | 2007 Jul |
|
Elevated vascular endothelial growth factor levels are associated with aortopulmonary collateral vessels in patients before and after the Fontan procedure. | 2007 Jun |
|
MR shoulder arthrography in patients younger than 40 years of age: frequency of rotator cuff tear versus labroligamentous pathology. | 2007 Jun |
|
Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts. | 2007 Jun |
|
Transcatheter arterial embolization of renal VX-2 carcinoma: ethiodol-ethanol capillary embolization combined with carboplatin. | 2007 Mar-Apr |
|
Injection rate threshold of triple-lumen central venous catheters: an in vitro study. | 2007 May |
|
Evaluation of the effects of noniodinized and iodinized ionic contrast media and gadoteric acid in acute necrotizing pancreatitis: experimental study in rabbits. | 2007 Nov |
|
Duplicated ectopic ureter with vaginal insertion: 3D CT urography with i.v. and percutaneous contrast administration. | 2007 Nov |
|
Efficacy of single-session percutaneous drainage and 50% acetic Acid sclerotherapy for treatment of simple renal cysts. | 2007 Nov-Dec |
|
High performance liquid chromatographic measurement of iothalamate in human serum and urine for evaluation of glomerular filtration rate. | 2007 Sep 1 |
|
Decreased incidence of acute rejection in adolescent kidney transplant recipients using antithymocyte induction and triple immunosuppression. | 2007 Sep 27 |
|
Inadvertent intrathecal administration of ionic contrast medium to a dog. | 2007 Sep-Oct |
|
Experimental study of intracranial hematoma detection with flat panel detector C-arm CT. | 2008 Apr |
|
Multidetector computed tomographic angiography in isolated third nerve palsy. | 2008 Aug |
|
Gradient-recalled echo sequences in direct shoulder MR arthrography for evaluating the labrum. | 2008 Jan |
|
Coraco- or costoclavicular paraosteoarthropathies in patients with severe central neurological disorders. | 2008 Mar |
|
Sweet's syndrome-like neutrophilic dermatosis resulting from exposure to a radiocontrast agent. | 2008 Mar |
Patents
Sample Use Guides
For carotid angiography—Percutaneous or via catheter, 5 to 12 mL of a solution containing the equivalent of 282 mg of iodine per mL, repeated as needed.
For vertebral angiography— Percutaneous or via catheter, 4 to 10 mL of a solution containing the equivalent of 282 mg of iodine per mL, repeated as needed.
For retrograde brachial cerebral angiography— Percutaneous, 35 to 50 mL of a solution containing the equivalent of 282 mg of iodine per mL as a single dose, administered rapidly into the brachial artery.
Route of Administration:
Intravascular
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1998838
Since the kidneys were perfused at constant flow, changes in renal perfusion pressure were directly proportional to changes in renal vascular resistance (RVR). The basal renal perfusion pressure was constant throughout each experiment varying between 60 and 80mmHg in different preparations. Each kidney was equilibrated for a 30- minute period prior to the addition of sodium iothalamate via a syringe pump linked to the perfusion line. Recovery to baseline was obtained between individual infusions in any one preparation. The contrast media solution in the syringe pump is termed the infusate, while the solution perfusing the kidney is termed the renal perfusate. Concentration response experiments were performed in each preparation. A 70% solution of sodium iothalamate (Conray 420) was infused into the perfusate line for 10-minute periods at predetermined rates to produce a range of iothalamate concentrations in the renal perfusate varying from 0.07% to 4.2%
Substance Class |
Chemical
Created
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admin
on
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Record UNII |
16CHD79MIX
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Record Status |
Validated (UNII)
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WHO-ATC |
V08AA04
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QV08AA04
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N0000180185
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N0000010258
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NCI_THESAURUS |
C28500
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759891
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C61792
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16CHD79MIX
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m6377
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Iothalamate
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Iotalamic acid
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