U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C11H9I3N2O4
Molecular Weight 613.9136
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOTHALAMIC ACID

SMILES

CNC(=O)C1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I

InChI

InChIKey=UXIGWFXRQKWHHA-UHFFFAOYSA-N
InChI=1S/C11H9I3N2O4/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20/h1-2H3,(H,15,18)(H,16,17)(H,19,20)

HIDE SMILES / InChI

Molecular Formula C11H9I3N2O4
Molecular Weight 613.9136
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/28028385 | https://www.ncbi.nlm.nih.gov/pubmed/26573558 | https://www.ncbi.nlm.nih.gov/pubmed/18650405

Iothalamic Acid is an iodine-containing organic anion used as a radiocontrast agent. It is available as sodium iothalamate (Iothalamate sodium) and meglumine iothalamate (Iothalmate meglumine). It can be administered intravenously or intravesically (into the urinary bladder). Iothalamate is indicated to visualize specific regions of the vascular system and blood flow in these areas to help in the diagnosis and evaluation of neoplasms (known or suspected) or vascular diseases (congenital or acquired) that may cause changes in normal vascular anatomy or physiology. Iothalamate meglumine injection is indicated for use in cerebral angiography, peripheral arteriography or venography, arterial digital subtraction angiography1 , and intravenous digital subtraction angiography. Iothalamate meglumine and iothalamate sodium injection is indicated for use in selective coronary arteriography, selective renal arteriography, and in intravenous digital subtraction angiography. othalamate meglumine and iothalamate sodium injection and iothalamate sodium injection are indicated to visualize the aorta and its major branches. However, the injection of iothalamate meglumine and iothalamate sodium is preferred because it generally causes less severe hemodynamic, neurotoxic, and cardiotoxic effects than the individual injection of iothalamate sodium. Radioactive formulation is also available as sodium iothalamate I-125 Injection (GLOFIL-125). It is indicated for evaluation of glomerular filtration in the diagnosis or monitoring of patients with renal disease.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
IOTHALAMATE SODIUM

Approved Use

Unknown

Launch Date

1976
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
64 h
63 mmol single, intravascular
dose: 63 mmol
route of administration: Intravascular
experiment type: SINGLE
co-administered:
IOTHALAMIC ACID serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
90.45%
IOTHALAMIC ACID plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.5
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.5
Disc. AE: Thromboembolic event, Myocardial infarction...
AEs leading to
discontinuation/dose reduction:
Thromboembolic event (serious)
Myocardial infarction (serious)
Stroke (serious)
Paralysis
Sources: Page: p.5
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.6
Disc. AE: Convulsions, Skin and subcutaneous conditions NEC...
AEs leading to
discontinuation/dose reduction:
Convulsions
Skin and subcutaneous conditions NEC (severe)
Sources: Page: p.6
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.7
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.7
Disc. AE: Stevens-Johnson syndrome, Toxic epidermal necrolysis...
AEs leading to
discontinuation/dose reduction:
Stevens-Johnson syndrome (severe)
Toxic epidermal necrolysis (severe)
Acute generalized exanthematous pustulosis (severe)
Drug reaction with eosinophilia and systemic symptoms (severe)
Sources: Page: p.7
AEs

AEs

AESignificanceDosePopulation
Paralysis Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.5
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.5
Myocardial infarction serious
Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.5
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.5
Stroke serious
Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.5
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.5
Thromboembolic event serious
Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.5
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.5
Convulsions Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.6
Skin and subcutaneous conditions NEC severe
Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.6
Acute generalized exanthematous pustulosis severe
Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.7
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.7
Drug reaction with eosinophilia and systemic symptoms severe
Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.7
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.7
Stevens-Johnson syndrome severe
Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.7
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.7
Toxic epidermal necrolysis severe
Disc. AE
200 mL single, intravenous
Recommended
Dose: 200 mL
Route: intravenous
Route: single
Dose: 200 mL
Sources: Page: p.7
unhealthy
Health Status: unhealthy
Condition: Excretory urography|cerebral angiography| peripheral arteriography|venography| arthrography |direct cholangiography |endoscopic retrograde cholangiopancreatography|contrast enhancement of computed tomographic brain images| cranial computerized angiotomography| intravenous digital subtraction angiography|arterial digital subtraction angiography
Sources: Page: p.7
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
[Recurrent aseptic meningitis (Mollaret meningitis)--spontaneous and drug-induced origin].
1991 Dec
Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease.
2004 Dec 21
Summaries for patients. Estimating kidney function in healthy people.
2004 Dec 21
Hypersensitivity to intravenous contrast material causing CT appearance of bowel wall thickening.
2004 Jul
Interferences in clinical capillary zone electrophoresis of serum proteins.
2004 Jun
Studies on experimental iodine allergy: 2. Iodinated protein antigens and their generation from inorganic and organic iodine-containing chemicals.
2004 May
Effect of contrast media on vascular smooth muscle cells.
2004 Oct
Sensitivity variation of doped Fricke gel irradiated with monochromatic synchrotron X rays between 33.5 and 80 keV.
2005
An alternative formula to the Cockcroft-Gault and the modification of diet in renal diseases formulas in predicting GFR in individuals with type 1 diabetes.
2005 Apr
Performance of the Cockcroft-Gault and modification of diet in renal disease equations in estimating GFR in ill hospitalized patients.
2005 Aug
Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry.
2005 Aug 26
Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia.
2005 Feb
Power injection of microcatheters: an in vitro comparison.
2005 Jan
Simultaneous determination of anions in nanoliter volumes.
2005 Jan
The value of contrast-enhanced helical CT scan with rectal contrast enema in the diagnosis of acute appendicitis.
2005 Jul-Aug
Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro.
2005 Jun
Telebrix Gastro in the management of adhesive small bowel obstruction.
2005 May
CT voiding cystourethrography using 16-MDCT for the evaluation of female urethral diverticula: initial experience.
2005 May
Simple HPLC-UV method for determination of iohexol, iothalamate, p-aminohippuric acid and n-acetyl-p-aminohippuric acid in human plasma and urine with ERPF, GFR and ERPF/GFR ratio determination using colorimetric analysis.
2005 Nov 5
PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients.
2005 Oct
Virtopsy: postmortem minimally invasive angiography using cross section techniques--implementation and preliminary results.
2005 Sep
[Pancreas anulare as an incidental finding in multidetector computer tomography for symptomatic abdominal aortic aneurysm].
2006 Apr
A novel approach to flexor hallucis longus tenography.
2006 Dec
Estimating absolute glomerular filtration rate in children.
2006 Dec
Effect on bone induction of using contrast media to reconstitute recombinant human bone morphogenetic protein-2 in an ectopic model in rats.
2006 Nov
Drawbacks and prognostic value of formulas estimating renal function in patients with chronic heart failure and systolic dysfunction.
2006 Oct 10
Reproducibility of renal function measurements in adult men with diabetic nephropathy: research and clinical implications.
2007
Renal handling of cystatin C.
2007 Apr
Endoscopic treatment of completely occluding anastomotic web using incision and ballooning after dye injection.
2007 Feb
Evidence that postprandial reduction of renal calcium reabsorption mediates hypercalciuria of patients with calcium nephrolithiasis.
2007 Jan
Preemptive living donor kidney transplantation: do the benefits extend to all recipients?
2007 Jan 27
[Renal radionuclide scintigraphy in the evaluation of radiopaque substances on renal function].
2007 Jan-Feb
Iodide mumps after contrast media imaging: a rare adverse effect to iodine.
2007 Jul
Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database.
2007 Jul
Elevated vascular endothelial growth factor levels are associated with aortopulmonary collateral vessels in patients before and after the Fontan procedure.
2007 Jun
MR shoulder arthrography in patients younger than 40 years of age: frequency of rotator cuff tear versus labroligamentous pathology.
2007 Jun
Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts.
2007 Jun
Transcatheter arterial embolization of renal VX-2 carcinoma: ethiodol-ethanol capillary embolization combined with carboplatin.
2007 Mar-Apr
Injection rate threshold of triple-lumen central venous catheters: an in vitro study.
2007 May
Evaluation of the effects of noniodinized and iodinized ionic contrast media and gadoteric acid in acute necrotizing pancreatitis: experimental study in rabbits.
2007 Nov
Duplicated ectopic ureter with vaginal insertion: 3D CT urography with i.v. and percutaneous contrast administration.
2007 Nov
Efficacy of single-session percutaneous drainage and 50% acetic Acid sclerotherapy for treatment of simple renal cysts.
2007 Nov-Dec
High performance liquid chromatographic measurement of iothalamate in human serum and urine for evaluation of glomerular filtration rate.
2007 Sep 1
Decreased incidence of acute rejection in adolescent kidney transplant recipients using antithymocyte induction and triple immunosuppression.
2007 Sep 27
Inadvertent intrathecal administration of ionic contrast medium to a dog.
2007 Sep-Oct
Experimental study of intracranial hematoma detection with flat panel detector C-arm CT.
2008 Apr
Multidetector computed tomographic angiography in isolated third nerve palsy.
2008 Aug
Gradient-recalled echo sequences in direct shoulder MR arthrography for evaluating the labrum.
2008 Jan
Coraco- or costoclavicular paraosteoarthropathies in patients with severe central neurological disorders.
2008 Mar
Sweet's syndrome-like neutrophilic dermatosis resulting from exposure to a radiocontrast agent.
2008 Mar
Patents

Patents

Sample Use Guides

For carotid angiography—Percutaneous or via catheter, 5 to 12 mL of a solution containing the equivalent of 282 mg of iodine per mL, repeated as needed. For vertebral angiography— Percutaneous or via catheter, 4 to 10 mL of a solution containing the equivalent of 282 mg of iodine per mL, repeated as needed. For retrograde brachial cerebral angiography— Percutaneous, 35 to 50 mL of a solution containing the equivalent of 282 mg of iodine per mL as a single dose, administered rapidly into the brachial artery.
Route of Administration: Intravascular
In Vitro Use Guide
Since the kidneys were perfused at constant flow, changes in renal perfusion pressure were directly proportional to changes in renal vascular resistance (RVR). The basal renal perfusion pressure was constant throughout each experiment varying between 60 and 80mmHg in different preparations. Each kidney was equilibrated for a 30- minute period prior to the addition of sodium iothalamate via a syringe pump linked to the perfusion line. Recovery to baseline was obtained between individual infusions in any one preparation. The contrast media solution in the syringe pump is termed the infusate, while the solution perfusing the kidney is termed the renal perfusate. Concentration response experiments were performed in each preparation. A 70% solution of sodium iothalamate (Conray 420) was infused into the perfusate line for 10-minute periods at predetermined rates to produce a range of iothalamate concentrations in the renal perfusate varying from 0.07% to 4.2%
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:01:52 GMT 2023
Edited
by admin
on Fri Dec 15 15:01:52 GMT 2023
Record UNII
16CHD79MIX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IOTHALAMIC ACID
MI   USAN   USP   USP-RS  
USAN  
Official Name English
IOTALAMIC ACID [MART.]
Common Name English
iotalamic acid [INN]
Common Name English
BENZOIC ACID, 3-(ACETYLAMINO)-2,4,6-TRIIODO-5-((METHYLAMINO)CARBONYL
Common Name English
MI-216
Code English
IOTHALAMATE [VANDF]
Common Name English
IOTALAMIC ACID
EP   INN   MART.   WHO-DD  
INN  
Official Name English
IOTALAMIC ACID [EP IMPURITY]
Common Name English
IOTHALAMATE
VANDF  
Common Name English
NSC-759891
Code English
IOTHALAMIC ACID [USAN]
Common Name English
IOTHALAMIC ACID [MI]
Common Name English
IOTHALAMIC ACID [USP MONOGRAPH]
Common Name English
IOTHALAMIC ACID [USP-RS]
Common Name English
IOTALAMIC ACID [JAN]
Common Name English
5-Acetamido-2,4,6-triiodo-N-methylisophthalamic acid
Systematic Name English
Iotalamic acid [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-ATC V08AA04
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
WHO-VATC QV08AA04
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
NDF-RT N0000180185
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
NDF-RT N0000010258
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
NCI_THESAURUS C28500
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
Code System Code Type Description
RXCUI
1546451
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
NSC
759891
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
INN
1371
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
EVMPD
SUB08254MIG
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
CAS
2276-90-6
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
NCI_THESAURUS
C61792
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
RXCUI
5970
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
ALTERNATIVE
FDA UNII
16CHD79MIX
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
DRUG BANK
DB09133
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
MERCK INDEX
m6377
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY Merck Index
LACTMED
Iothalamate
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
WIKIPEDIA
Iotalamic acid
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201300
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
ECHA (EC/EINECS)
218-897-4
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
DRUG CENTRAL
1469
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
PUBCHEM
3737
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
SMS_ID
100000083092
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
MESH
D007483
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
EPA CompTox
DTXSID5023164
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
RS_ITEM_NUM
1345002
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
DAILYMED
16CHD79MIX
Created by admin on Fri Dec 15 15:01:52 GMT 2023 , Edited by admin on Fri Dec 15 15:01:52 GMT 2023
PRIMARY
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