| Stereochemistry | ABSOLUTE |
| Molecular Formula | C45H73NO15 |
| Molecular Weight | 868.0588 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 26 / 26 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CC[C@H](C)CN1[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@H](CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C)O[C@@H]7O[C@H](CO)[C@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]7O[C@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O
InChI
InChIKey=ZGVSETXHNHBTRK-OTYSSXIJSA-N
InChI=1S/C45H73NO15/c1-19-6-9-27-20(2)31-28(46(27)16-19)15-26-24-8-7-22-14-23(10-12-44(22,4)25(24)11-13-45(26,31)5)57-43-40(61-41-37(54)35(52)32(49)21(3)56-41)39(34(51)30(18-48)59-43)60-42-38(55)36(53)33(50)29(17-47)58-42/h7,19-21,23-43,47-55H,6,8-18H2,1-5H3/t19-,20+,21-,23-,24+,25-,26-,27+,28-,29+,30+,31-,32-,33+,34-,35+,36-,37+,38+,39-,40+,41+,42-,43+,44-,45-/m0/s1
| Molecular Formula | C45H73NO15 |
| Molecular Weight | 868.0588 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 25 / 26 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
α-Solanine is a glycoalkaloid found in species of the nightshade family including potato. The name is derived from the Latin for European black nightshade (Solanum nigrum), from which solanine was first isolated in 1820. It was primarily reported to have toxic effects in humans. However, there is a growing body of literature demonstrating in vitro and in vivo anticancer activity of α-solanine. Most of these studies have shown activation of apoptosis as the underlying mechanism in antitumor activity of α-solanine. Naturally occurring BuChE and AChE inhibitor.
CNS Activity
Originator
Approval Year
PubMed
Sample Use Guides
The Syrian Golden hamster was given daily doses of a-solanine and a-chaconine by gavage for 28 days. Doses of up to 33.3 mg total glycoalkaloids/ kg body weight were applied in ratios of 1:3.7 and 1:70 (a-solanine:a-chaconine). Administration of the highest doses of both ratios resulted in distended and fluid filled small intestines and stomach. Animals receiving the ratio with the reduced content of a-solanine were less affected compared to those receiving the other ratio.
Route of Administration:
Oral
EC9706 and Eca109 cell lines were exposed to a range of concentrations of α solanine (10, 20, 40 and 60 μg/ml) for 24, 48 and 72 h. Cell proliferation was determined by measuring the absorbance at 450 nm. Compared with the control, (without α solanine), cell proliferation was markedly inhibited at different concen¬trations in the α solanine group in a dose and time dependent manner