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Details

Stereochemistry ACHIRAL
Molecular Formula C7H10N4O2S
Molecular Weight 214.245
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULFAGUANIDINE

SMILES

NC(=N)NS(=O)(=O)C1=CC=C(N)C=C1

InChI

InChIKey=BRBKOPJOKNSWSG-UHFFFAOYSA-N
InChI=1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)

HIDE SMILES / InChI

Molecular Formula C7H10N4O2S
Molecular Weight 214.245
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Sulfaguanidine is used to treat the gastrointestinal infections particularly bacillary dysentery. Sulfaguanidine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase in bacteria. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown
Curative
ENTEROPATHYL

Cmax

ValueDoseCo-administeredAnalytePopulation
0.41 μg/mL
2.5 mg/kg single, oral
SULFAGUANIDINE plasma
Rattus norvegicus

AUC

ValueDoseCo-administeredAnalytePopulation
1.04 μg × h/mL
2.5 mg/kg single, oral
SULFAGUANIDINE plasma
Rattus norvegicus

T1/2

ValueDoseCo-administeredAnalytePopulation
1.8 h
2.5 mg/kg single, oral
SULFAGUANIDINE plasma
Rattus norvegicus

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
0.08 mg/kg per day; 7-14 days (daily dose: 2-3 mg)
Route of Administration: Oral
In Vitro Use Guide
Sulfaguanidine at dose of 2500 ppm proved to be most toxic against A. corymbifera causing 56.39 percent inhibition in the mycelial growth, while the same dose could not be found much effective against other test fungi.
Substance Class Chemical
Record UNII
15XQ8043FN
Record Status Validated (UNII)
Record Version