SOQUINOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H26N2O3
Molecular Weight	306.3999
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC(O)COC1=CC=CC2=C1CCN(C2)C=O

InChI

InChIKey=GMJHUSJLZXFFQJ-UHFFFAOYSA-N

InChI=1S/C17H26N2O3/c1-17(2,3)18-9-14(21)11-22-16-6-4-5-13-10-19(12-20)8-7-15(13)16/h4-6,12,14,18,21H,7-11H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C17H26N2O3
Molecular Weight	306.3999
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://adisinsight.springer.com/drugs/800000152 | https://www.ncbi.nlm.nih.gov/pubmed/2906243

Soquinolol [WE 704] is a β-blocker that was under clinical development for the treatment of heart failure, but this research was discontinued. Soquinolol is a highly potent non-subtype-selective beta-adrenergic receptor blocker, which is devoid of any intrinsic sympathomimetic activity. Its local anaesthetic activity (membrane stabilizing effect) is very weak. It also shows good enteral efficacy and long duration of action. In binding studies with heart (Ki beta 1 = 3.25 nmol/l) and lung membranes (Ki beta 2 = 0.85 nmol/l) its binding profile was found to be similar to that of propranolol.

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

In the conscious dog soquinolol's beta 1-adrenergic blocking activity (ED 50%) on intravenous injection (5.5 ug/kg) and oral administration (5.8 ug/kg) is about twice as great as that of pindolol and 19 times (i.v.) or 138 times (p.o.) greater than that of propranolol.

Route of Administration: Other

In Vitro Use Guide

In binding studies with heart (Ki beta 1 = 3.25 nmol/l) and lung membranes (Ki beta 2 = 0.85 nmol/l) Soquinolol's binding profile was found to be similar to that of propranolol. Soquinolol inhibits the isoprenaline-induced tachycardia (EC50% = 48 ug/l) in the guinea-pig Langendorff heart in vitro.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:05:48 GMT 2023` Edited by `admin` on `Fri Dec 15 16:05:48 GMT 2023`
Record UNII	15CC9BOH7Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SOQUINOLOL

Official Name

English

Soquinolol [WHO-DD]

Common Name

English

soquinolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576