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Details

Stereochemistry ABSOLUTE
Molecular Formula C13H11N3O4S
Molecular Weight 305.309
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of BLI-489 FREE ACID

SMILES

[H][C@]12SC=C(N1C(=O)\C2=C\C3=CN4CCOCC4=N3)C(O)=O

InChI

InChIKey=DMEYZPJEFHGESJ-CPWLGJMPSA-N
InChI=1S/C13H11N3O4S/c17-11-8(12-16(11)9(6-21-12)13(18)19)3-7-4-15-1-2-20-5-10(15)14-7/h3-4,6,12H,1-2,5H2,(H,18,19)/b8-3-/t12-/m1/s1

HIDE SMILES / InChI
Molecular Formula C13H11N3O4S
Molecular Weight 305.309
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 1
Optical Activity UNSPECIFIED

Description

BLI 489 was developed by Wyeth as a 6-methylidene-penem β-lactamase inhibitor for the treatment of bacterial infections and urinary tract infections. BLI-489 has shown the promising clinical data, however, development of this drug, was discontinued.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489.
2009 Feb
Relationship between β-lactamase production and resistance phenotype in Klebsiella pneumoniae strains.
2017 Jul 6

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:23:40 GMT 2023
Edited
by admin
on Fri Dec 15 16:23:40 GMT 2023
Record UNII
156B510BCG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BLI-489 FREE ACID
Common Name English
BLI 489 FREE ACID
Common Name English
4-THIA-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID, 6-((5,6-DIHYDRO-8H-IMIDAZO(2,1-C)(1,4)OXAZIN-2-YL)METHYLENE)-7-OXO-, (5R,6Z)-
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID60212945
Created by admin on Fri Dec 15 16:23:40 GMT 2023 , Edited by admin on Fri Dec 15 16:23:40 GMT 2023
PRIMARY
PUBCHEM
9972353
Created by admin on Fri Dec 15 16:23:40 GMT 2023 , Edited by admin on Fri Dec 15 16:23:40 GMT 2023
PRIMARY
CAS
635322-76-8
Created by admin on Fri Dec 15 16:23:40 GMT 2023 , Edited by admin on Fri Dec 15 16:23:40 GMT 2023
PRIMARY
FDA UNII
156B510BCG
Created by admin on Fri Dec 15 16:23:40 GMT 2023 , Edited by admin on Fri Dec 15 16:23:40 GMT 2023
PRIMARY
Related Record Type Details
Structure of BLI-489
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of BLI-489 FREE ACID
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