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Details

Stereochemistry ACHIRAL
Molecular Formula C22H23F2NO2
Molecular Weight 371.4203
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LENPERONE

SMILES

FC1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)C(=O)C3=CC=C(F)C=C3

InChI

InChIKey=WCIBOXFOUGQLFC-UHFFFAOYSA-N
InChI=1S/C22H23F2NO2/c23-19-7-3-16(4-8-19)21(26)2-1-13-25-14-11-18(12-15-25)22(27)17-5-9-20(24)10-6-17/h3-10,18H,1-2,11-15H2

HIDE SMILES / InChI
Molecular Formula C22H23F2NO2
Molecular Weight 371.4203
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Lenperone (AHR 2277), or 4’-fluoro-4 [4-(p-fluorobenzoyl) piperidino] butyrophenone hydrochloride, is an antipsychotic compound which has been shown in preliminary experiments to possess those features essential for neuroleptic activity. Dopamine antagonist.

CNS Activity

CNS Active
3,913

Originator

Wyeth
116

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
Serotonin 2 (5-HT2) receptor
87
Antagonist
2,778
 4.3 nM [Ki]
Dopamine receptor
60
Antagonist
2,778

Conditions

ConditionModalityTargetsHighest PhaseProduct
Schizophrenia
298
 Primary
Approved
8,429
Lenperone

Doses

PubMed

Patents

US20010023254A1
2
US4565821
2
US5955459
8
US6680047
2
WO1999026661A1
2

Sample Use Guides

In Vivo Use Guide
50 hospitalized schizophrenic patients were treated 20-30 days with Lenperone. The therapeutic effective dose was 30-50 mg/day. The highest daily dosage was 90 mg.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
13P4GX22ES
Record Status Validated (UNII)
Record Version
NIH
NCATS
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