METIAZINIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H13NO2S
Molecular Weight	271.334
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=CC=CC=C2SC3=CC=C(CC(O)=O)C=C13

InChI

InChIKey=LMINNBXUMGNKMM-UHFFFAOYSA-N

InChI=1S/C15H13NO2S/c1-16-11-4-2-3-5-13(11)19-14-7-6-10(8-12(14)16)9-15(17)18/h2-8H,9H2,1H3,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C15H13NO2S
Molecular Weight	271.334
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: DOI: 10.1177/030006057200100106

Metiazinic acid is a non-steroidal agent and has been found in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and osteoarthrosis to possess anti-inflammatory activity

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
negative regulation of platelet aggregation 1 Target ID: GO:0090331 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6318340	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatoid arthritis 320 Sources: DOI: 10.1177/030006057200100106	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Methiazinic acid (Soripal) in the treatment of inflammatory and degenerative diseases of the knee joint].	1974-04	4857508
[Toxicologic study of methiazinic acid (16091 R.P)].	1969-08	5306808
[General pharmacological properties of methiazinic acid (16091 RP)].	1969-08	4390179

Sample Use Guides

In Vivo Use Guide

1.5 g per day for a week

Route of Administration: Oral

In Vitro Use Guide

50 uM to protect bacteriophage T2 from inactivation by the model peroxy radical CCl3O2

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:55:57 GMT 2025` Edited by `admin` on `Mon Mar 31 17:55:57 GMT 2025`
Record UNII	12I0HHE2ZY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METIAZINIC ACID

Official Name

English

RP 16091

Preferred Name

English

METIAZINIC ACID [MART.]

Common Name

English

METIAZINIC ACID [MI]

Common Name

English

metiazinic acid [INN]

Common Name

English

10-METHYL-2-PHENOTHIAZINYL ACETIC ACID

Systematic Name

English

Metiazinic acid [WHO-DD]

Common Name

English

RP-16091

Code

English

METIAZINIC ACID [JAN]

Common Name

English

Code System Code Type Description

PUBCHEM

4164