TRICHLOROETHANE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3Cl3
Molecular Weight	133.404
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(Cl)(Cl)Cl

InChI

InChIKey=UOCLXMDMGBRAIB-UHFFFAOYSA-N

InChI=1S/C2H3Cl3/c1-2(3,4)5/h1H3

HIDE SMILES / InChI

Molecular Formula	C2H3Cl3
Molecular Weight	133.404
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.epa.gov/sites/production/files/2016-09/documents/methyl-chloroform.pdf | https://jamanetwork.com/journals/jama/article-abstract/360630 | http://apps.sepa.org.uk/spripa/Pages/SubstanceInformation.aspx?pid=68 | https://www.nature.com/articles/nature01311

1,1,1-trichloroethane (methyl chloroform) is a colorless liquid or vapour with a sharp sweet smell. It dissolves in water and other chemicals and easily evaporates into the air. TCE is non-flammable. Trichloroethane is used as a solvent and degreasing agent in industry. It is an ingredient in consumer products such as household cleaners, glues, and aerosol sprays. Methyl chloroform is also used as a chemical intermediate in the production of vinylidene chloride. It was formerly used as a food and grain fumigant. Excessive absorption of this substance through the lungs or gastrointestinal tract produces central nervous system (CNS) depression proportional to the amount absorbed. Mild liver and kidney dysfunction may occur transiently following recovery from CNS depression. The consumption of trichloroethane has been banned by the 1987 Montreal Protocol because of its ozone-depleting potential.

CNS Activity

Approval Year

Doses

Dose	Population	Adverse events
735 ppm multiple, respiratory Studied dose Dose: 735 ppm Route: respiratory Route: multiple Dose: 735 ppm Sources: https://pubmed.ncbi.nlm.nih.gov/7329041/	healthy, 16 years Health Status: healthy Age Group: 16 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7329041/	Other AEs: Death... Other AEs: Death Sources: https://pubmed.ncbi.nlm.nih.gov/7329041/
17718 ppm multiple, respiratory Studied dose Dose: 17718 ppm Route: respiratory Route: multiple Dose: 17718 ppm Sources: https://pubmed.ncbi.nlm.nih.gov/2669664/	healthy, 27 years Health Status: healthy Age Group: 27 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/2669664/	Other AEs: Hepatitis... Other AEs: Hepatitis Sources: https://pubmed.ncbi.nlm.nih.gov/2669664/
1380 ppm 1 times / day single, respiratory Studied dose Dose: 1380 ppm, 1 times / day Route: respiratory Route: single Dose: 1380 ppm, 1 times / day Sources: https://www.tandfonline.com/doi/abs/10.1080/00028896109343404	healthy, 30 to 60 years Health Status: healthy Age Group: 30 to 60 years Sex: M Sources: https://www.tandfonline.com/doi/abs/10.1080/00028896109343404	Other AEs: Anesthesia... Other AEs: Anesthesia Sources: https://www.tandfonline.com/doi/abs/10.1080/00028896109343404
1 % 1 times / day single, topical Studied dose Dose: 1 %, 1 times / day Route: topical Route: single Dose: 1 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/1838318/	healthy, 30 years Health Status: healthy Age Group: 30 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/1838318/	Other AEs: Contact dermatitis... Other AEs: Contact dermatitis Sources: https://pubmed.ncbi.nlm.nih.gov/1838318/
90 % multiple, topical Studied dose Dose: 90 % Route: topical Route: multiple Dose: 90 % Sources: https://pubmed.ncbi.nlm.nih.gov/8673514/	healthy, 31 years Health Status: healthy Age Group: 31 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/8673514/	Other AEs: Paresthesia distal... Other AEs: Paresthesia distal Sources: https://pubmed.ncbi.nlm.nih.gov/8673514/
1 oz 1 times / day single, oral Studied dose Dose: 1 oz, 1 times / day Route: oral Route: single Dose: 1 oz, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/	healthy, 47 years Health Status: healthy Age Group: 47 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/	Other AEs: Nausea, Vomiting... Other AEs: Nausea Vomiting Diarrhea Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/

AEs

AE	Dose	Population
Death	735 ppm multiple, respiratory Studied dose Dose: 735 ppm Route: respiratory Route: multiple Dose: 735 ppm Sources: https://pubmed.ncbi.nlm.nih.gov/7329041/	healthy, 16 years Health Status: healthy Age Group: 16 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7329041/
Hepatitis	17718 ppm multiple, respiratory Studied dose Dose: 17718 ppm Route: respiratory Route: multiple Dose: 17718 ppm Sources: https://pubmed.ncbi.nlm.nih.gov/2669664/	healthy, 27 years Health Status: healthy Age Group: 27 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/2669664/
Anesthesia	1380 ppm 1 times / day single, respiratory Studied dose Dose: 1380 ppm, 1 times / day Route: respiratory Route: single Dose: 1380 ppm, 1 times / day Sources: https://www.tandfonline.com/doi/abs/10.1080/00028896109343404	healthy, 30 to 60 years Health Status: healthy Age Group: 30 to 60 years Sex: M Sources: https://www.tandfonline.com/doi/abs/10.1080/00028896109343404
Contact dermatitis	1 % 1 times / day single, topical Studied dose Dose: 1 %, 1 times / day Route: topical Route: single Dose: 1 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/1838318/	healthy, 30 years Health Status: healthy Age Group: 30 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/1838318/
Paresthesia distal	90 % multiple, topical Studied dose Dose: 90 % Route: topical Route: multiple Dose: 90 % Sources: https://pubmed.ncbi.nlm.nih.gov/8673514/	healthy, 31 years Health Status: healthy Age Group: 31 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/8673514/
Diarrhea	1 oz 1 times / day single, oral Studied dose Dose: 1 oz, 1 times / day Route: oral Route: single Dose: 1 oz, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/	healthy, 47 years Health Status: healthy Age Group: 47 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/
Nausea	1 oz 1 times / day single, oral Studied dose Dose: 1 oz, 1 times / day Route: oral Route: single Dose: 1 oz, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/	healthy, 47 years Health Status: healthy Age Group: 47 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/
Vomiting	1 oz 1 times / day single, oral Studied dose Dose: 1 oz, 1 times / day Route: oral Route: single Dose: 1 oz, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/	healthy, 47 years Health Status: healthy Age Group: 47 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/5951961/

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP2E1 729 CYP2B 10 CYP2C 16 CYP3A 220	CYP450 32

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP450 41	inducer 1966 Sources: https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0197tr.pdf#page=27 Page: 27.0	likely

Drug as victim

Target	Modality	Activity
CYP2B 10	substrate 4014 Sources: https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0197tr.pdf#page=27 Page: 28.0	yes
CYP2C 16	substrate 4014 Sources: https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0197tr.pdf#page=27 Page: 28.0	yes
CYP2E1 729	substrate 4014 Sources: https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0197tr.pdf#page=27 Page: 28.0	yes
CYP3A 220	substrate 4014 Sources: https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0197tr.pdf#page=27 Page: 28.0	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B4-0530	http://www.3bsc.com/index/pro_info.php?id=18378
3B Scientific (Wuhan) Corp	3B4-0531	http://www.3bsc.com/index/pro_info.php?id=18379
3B Scientific (Wuhan) Corp	3B4-2973	http://www.3bsc.com/index/pro_info.php?id=77606
Acadechem	ACDS-023216	http://www.acadechemical.com/product/97915
Acadechem	ACDS-074243	http://www.acadechemical.com/product/148942
Achemtek	0104-003604	http://www.achemtek.com/71-55-6
AK Scientific, Inc. (AKSCI)	M983	http://www.aksci.com/item_detail.php?cat=M983
Angene	AGN-PC-0WHEWL	http://www.angenechemical.com/productshow/AGN-PC-0WHEWL.html
Avantor Inc	75835-530	https://us.vwr.com/store/product/21998657/usp-60-467-62-singles-restek
BOC Sciences	25323-89-1	https://www.bocsci.com/trichloroethane-cas-25323-89-1-item-64215.html
BOC Sciences	90229-85-9	https://www.bocsci.com/1-1-1-trichloroethane-2-d1-cas-90229-85-9-item-78978.html
ChemMol	49416606	http://www.chemmol.com/chemmol/49416606.html
ChemMol	99138547	http://www.chemmol.com/chemmol/99138547.html
Clearsynth	CS-O-14593	https://www.clearsynth.com/en/CSO14593.html
Finetech	FT-0605938	http://www.finetechnology-ind.com/prod/detail/pub/71-55-6.html
Finetech	FT-0605984	http://www.finetechnology-ind.com/prod/detail/pub/79-01-6.html
Glentham Life Sciences	GK4661	http://www.glentham.com/products/product/GK4661/
iChemical	EBD3068811	http://www.ichemical.com/products/71-55-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
LGC Standards	DRE-CA17738300	https://www.lgcstandards.com/US/en/p/DRE-CA17738300
LGC Standards	DRE-GA09011085ME	https://www.lgcstandards.com/US/en/p/DRE-GA09011085ME
LGC Standards	DRE-L17738300ME	https://www.lgcstandards.com/US/en/p/DRE-L17738300ME
LGC Standards	DRE-XA17738300ME	https://www.lgcstandards.com/US/en/p/DRE-XA17738300ME
mcule	MCULE-5353008945	https://mcule.com/MCULE-5353008945/
Sigma-Aldrich	T54704_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/t54704?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S007559	http://www.sinfoobiotech.com/product/1010957
Sinfoo Biotech	S058586	http://www.sinfoobiotech.com/product/1061984
Smolecule	S569912	https://www.smolecule.com/products/s569912
THE BioTek	bt-288974	https://www.thebiotek.com/product/others/bt-288974
Yuhao Chemical	HL1090	http://www.chemyuhao.com/71-55-6.html
Yuhao Chemical	JZ5685	http://www.chemyuhao.com/25323-89-1.html

PubMed

Title	Date	PubMed
1,1,1-trichloroethane marine risk assessment with special reference to the OSPARCOM region: North Sea.	2004-10	15376378
Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron.	2004-10	15358490
Neurologic abnormalities in workers of a 1-bromopropane factory.	2004-09	15345346
Chlorinated hydrocarbon solvents.	2004-08	15325317
Biologic markers of exposure to chlorinated solvents.	2004-08	15325313
Trichloroethylene and cardiac malformations.	2004-08	15289177
Acute effects of 1,1,1-trichloroethane on human olfactory functioning.	2004-05-22	15152877
Intravenous self-administration of abused solvents and anesthetics in mice.	2004-02-06	14757143
Photolysis of chloral under atmospheric conditions.	2004-02-01	14968871
Rapid and sensitive static headspace gas chromatography-mass spectrometry method for the analysis of ethanol and abused inhalants in blood.	2004-01-25	14670752
Synthesis and protection of aryl sulfates using the 2,2,2-trichloroethyl moiety.	2004-01-22	14723530
Pi-halogen dimer interactions and the inclusion chemistry of a new tetrahalo aryl host.	2004-01-21	14737639
Changes in the regional emissions of greenhouse gases and ozone-depleting compounds.	2004-01-15	14750708
Reduction of halogenated ethanes by green rust.	2004-01	14768865
Ambient, indoor and personal exposure relationships of volatile organic compounds in Mexico City Metropolitan Area.	2004	15118753
Personal, indoor, and outdoor VOC exposures in a probability sample of children.	2004	15118740
Investigation of the inhibitory effect of silica on the degradation of 1,1,1-trichloroethane by granular iron.	2003-12-15	14717199
The effect of multicomponent diffusion on NAPL dissolution from spherical ternary mixtures.	2003-12	14607469
Comparative study of the effects of toluene, benzene, 1,1,1-trichloroethane, diethyl ether, and flurothyl on anxiety and nociception in mice.	2003-11-15	14613712
VOC removal from contaminated groundwater through membrane pervaporation. (II): 1,1,1-trichloroethane-SDS surfactant solution system.	2003-11	14758903
Adsorption of volatile organic compounds by pecan shell- and almond shell-based granular activated carbons.	2003-11	12895561
Linear free-energy relationship analysis of the fate of chlorinated 1- and 2-carbon compounds by redox-manipulated smectite clay minerals.	2003-10	14551992
Six interaction profiles for simple mixtures.	2003-10	12892681
Dissolution of entrapped DNAPLs in variable aperture fractures: experimental data and empirical model.	2003-09-15	14524445
Biofiltration of 1,1,1-trichloroethane by a trickle-bed air biofilter.	2003-09	14512633
Sorption of volatile organic compounds on typical carpet fibers.	2003-08	12742400
Environmental risk assessment of airborne trichloroacetic acid--a contribution to the discussion on the significance of anthropogenic and natural sources.	2003-07	12738278
Input of trichloroacetic acid into the vegetation of various climate zones--measurements on several continents.	2003-07	12738268
Fluxes of trichloroacetic acid between atmosphere, biota, soil, and groundwater.	2003-07	12738257
Quantitative structure-property relationships for physiologically based pharmacokinetic modeling of volatile organic chemicals in rats.	2003-06-15	12791307
Evaluation of toluene dependence and cross-sensitization to diazepam.	2003-05-16	12706489
Inhaled drugs of abuse enhance serotonin-3 receptor function.	2003-05-01	12681521
Dehydrochlorination of 1,1,1-trichloroethane and pentachloroethane by microbially reduced ferruginous smectite.	2003-05	12729213
Biodegradation of chlorinated solvents in a water unsaturated topsoil.	2003-04	12586147
Effects of inhaled toluene and 1,1,1-trichloroethane on seizures and death produced by N-methyl-D-aspartic acid in mice.	2003-03-18	12644292
An evaluation of Fourier transform infrared (FTIR) spectroscopy for detecting organic solvents in expired breath.	2003-03	12573961
Fast estimation of hydrogen-bonding donor and acceptor propensities: a GMIPp study.	2003-02-27	12602951
Evaluation of bacterial aerotaxis for its potential use in detecting the toxicity of chemicals to microorganisms.	2003-02-27	12523965
VOC exposures in a mixed-use university art building.	2003-02-07	12570077
Development of a new respirator for organic vapors with a breakthrough detector using a semiconductor gas sensor.	2003-02	12519683
Stable hydrogen, carbon and chlorine isotope measurements of selected chlorinated organic solvents.	2003-02	12504360
Continuing emissions of methyl chloroform from Europe.	2003-01-09	12520294
Trichloroacetic acid in Norway spruce/soil-system. I. Biodegradation in soil.	2003-01	12656249
[1,1, 1-trichloroethane-induced chronic active hepatitis].	2003-01	12594376
The annual course of TCA formation in the lower troposphere: a modeling study.	2003	12758020
Kinetics of 1,1,1-trichloroethane transformation by iron sulfide and a methanogenic consortium.	2002-11-01	12433162
Microbial dehalorespiration with 1,1,1-trichloroethane.	2002-11-01	12411705
[Method for determining chlorinated solvent residues in dry cleaning fabrics with gas chromatography-mass spectrometry].	2002-11	12683012
Comparison of anaerobic dechlorinating enrichment cultures maintained on tetrachloroethene, trichloroethene, cis-dichloroethene and vinyl chloride.	2002-10	12420924
Tolerance to various toxicants by marine bacteria highly resistant to mercury.	2001-10-24	12876655

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:31 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:31 GMT 2025`
Record UNII	113C650IR1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRICHLOROETHANE

Official Name

English

1,1,1-TRICHLOROETHANE

Preferred Name

English

TRICHLOROETHANE [VANDF]

Common Name

English

ALPHA-T

Common Name

English

SOLVENT 111

Common Name

English

1,1,1-TRICHLOROETHANE [USP-RS]

Common Name

English

METHYLTRICHLOROMETHANE

Systematic Name

English

TRICHLOROETHANE [MART.]

Common Name

English

NSC-9367

Code

English

RCRA-U226

Code

English

UN-2831

Code

English

1,1,1-TRICHLOROETHANE [MI]

Common Name

English

CLEANITE

Brand Name

English

CHLOROTHENE

Common Name

English

TRICHLOROETHANE [II]

Common Name

English

1,1,1 TRICHLOROETHANE

Systematic Name

English

METHYLCHLOROFORM [HSDB]

Common Name

English

1,1,1-TCE

Common Name

English

1,1,1-TRICHLOROETHANE [IARC]

Common Name

English

GENKLENE LB

Brand Name

English

METHYLCHLOROFORM

Systematic Name

English

1,1,1 TRICHLOROETHANE [VANDF]

Common Name

English

.ALPHA.-TRICHLOROETHANE

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 216.24