TETRAHYDROZOLINE HYDROCHLORIDE

US Approved OTC

First approved in 1954

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H16N2.ClH
Molecular Weight	236.74
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TETRAHYDROZOLINE HYDROCHLORIDE

Structure Search

SMILES

Cl.C1CN=C(N1)C2CCCC3=C2C=CC=C3

InChI

InChIKey=BJORNXNYWNIWEY-UHFFFAOYSA-N

InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C13H16N2
Molecular Weight	200.2795
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.rxresource.org/prescription-information/Tyzine-Pediatric-Fougera-Pharmaceuticals-Inc.html

Tetrahydrozoline is an alpha adrenergic receptor agonist, which is used in form of nasal solution or spray (Tyzin) for decongestion of nasal and nasopharyngeal mucosa.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha 64 Target ID: CHEMBL2095203 Sources: www.ncbi.nlm.nih.gov/pubmed/18259967	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Nasal congestion 26 Sources: http://www.rxresource.org/prescription-information/Tyzine-Pediatric-Fougera-Pharmaceuticals-Inc.html	Curative		Approved 8429	TYZINE Approved Use Tyzine Nasal Solution is indicated for decongestion of nasal and nasopharyngeal mucosa. Launch Date 1979

C_max

Value	Dose	Co-administered	Analyte	Population
0.218 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21972870/	2 drop 4 times / day multiple, ocular dose: 2 drop route of administration: Ocular experiment type: MULTIPLE co-administered:		TETRAHYDROZOLINE serum	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
3.46 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21972870/	2 drop 4 times / day multiple, ocular dose: 2 drop route of administration: Ocular experiment type: MULTIPLE co-administered:		TETRAHYDROZOLINE serum	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21972870/	2 drop 4 times / day multiple, ocular dose: 2 drop route of administration: Ocular experiment type: MULTIPLE co-administered:		TETRAHYDROZOLINE serum	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
7500 ug single, oral Overdose Dose: 7500 ug Route: oral Route: single Dose: 7500 ug Sources: https://pubmed.ncbi.nlm.nih.gov/15388224	healthy, 16 years n = 1 Health Status: healthy Age Group: 16 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/15388224	Other AEs: Sinoatrial node dysfunction... Other AEs: Sinoatrial node dysfunction (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15388224
0.3 mg/kg single, oral Overdose Dose: 0.3 mg/kg Route: oral Route: single Dose: 0.3 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/21740144	healthy, 20 months-2 years n = 2 Health Status: healthy Age Group: 20 months-2 years Sex: M+F Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/21740144	Other AEs: Bradycardia, Hypertension... Other AEs: Bradycardia (2 patients) Hypertension (1 patient) Gasping (2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/21740144
250 ug 3 times / day multiple, oral Overdose Dose: 250 ug, 3 times / day Route: oral Route: multiple Dose: 250 ug, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20723124	unhealthy, 25 days n = 1 Health Status: unhealthy Age Group: 25 days Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/20723124	Other AEs: Hypotonia... Other AEs: Hypotonia (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/20723124
250 ug 3 times / day multiple, oral Overdose Dose: 250 ug, 3 times / day Route: oral Route: multiple Dose: 250 ug, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20723124	unhealthy, 25 days n = 1 Health Status: unhealthy Condition: mild fever Age Group: 25 days Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/20723124	Other AEs: Apnea... Other AEs: Apnea (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/20723124
15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	Other AEs: Hypothermia, Bradycardia... Other AEs: Hypothermia (1 patient) Bradycardia (1 patient) Hypotension (1 patient) Miosis (1 patient) Lethargy (1 patient) Mucous membrane disorder (NOS) (1 patient) Bowel sounds decreased (1 patient) Chest pain (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/8530784

AEs

AE	Significance	Dose	Population
Sinoatrial node dysfunction	1 patient	7500 ug single, oral Overdose Dose: 7500 ug Route: oral Route: single Dose: 7500 ug Sources: https://pubmed.ncbi.nlm.nih.gov/15388224	healthy, 16 years n = 1 Health Status: healthy Age Group: 16 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/15388224
Hypertension	1 patient	0.3 mg/kg single, oral Overdose Dose: 0.3 mg/kg Route: oral Route: single Dose: 0.3 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/21740144	healthy, 20 months-2 years n = 2 Health Status: healthy Age Group: 20 months-2 years Sex: M+F Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/21740144
Bradycardia	2 patients	0.3 mg/kg single, oral Overdose Dose: 0.3 mg/kg Route: oral Route: single Dose: 0.3 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/21740144	healthy, 20 months-2 years n = 2 Health Status: healthy Age Group: 20 months-2 years Sex: M+F Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/21740144
Gasping	2 patients	0.3 mg/kg single, oral Overdose Dose: 0.3 mg/kg Route: oral Route: single Dose: 0.3 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/21740144	healthy, 20 months-2 years n = 2 Health Status: healthy Age Group: 20 months-2 years Sex: M+F Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/21740144
Hypotonia	1 patient	250 ug 3 times / day multiple, oral Overdose Dose: 250 ug, 3 times / day Route: oral Route: multiple Dose: 250 ug, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20723124	unhealthy, 25 days n = 1 Health Status: unhealthy Age Group: 25 days Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/20723124
Apnea	1 patient	250 ug 3 times / day multiple, oral Overdose Dose: 250 ug, 3 times / day Route: oral Route: multiple Dose: 250 ug, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20723124	unhealthy, 25 days n = 1 Health Status: unhealthy Condition: mild fever Age Group: 25 days Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/20723124
Bowel sounds decreased	1 patient	15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784
Bradycardia	1 patient	15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784
Chest pain	1 patient	15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784
Hypotension	1 patient	15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784
Hypothermia	1 patient	15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784
Lethargy	1 patient	15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784
Miosis	1 patient	15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784
Mucous membrane disorder (NOS)	1 patient	15000 ug single, oral Overdose Dose: 15000 ug Route: oral Route: single Dose: 15000 ug Sources: https://pubmed.ncbi.nlm.nih.gov/8530784	healthy, 41 years n = 1 Health Status: healthy Age Group: 41 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/8530784

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY573823	https://www.001chemical.com/chem/84-22-0
3B Scientific (Wuhan) Corp	3B2-4921	http://www.3bsc.com/index/pro_info.php?id=79861
AHH Chemical co.,ltd	MR-1085668	http://www.ahhchemical.com/product/MR-1085668.html
Alinda	ALBB-023224	http://alinda.ru/finechem_en_.html?i=ALBB-023224
Ambeed	A187603	https://www.ambeed.com/products/84-22-0.html
BLD Pharm	BD153519	http://www.bldpharm.com/products/84-22-0.html
Chem Scene	CS-0009512	http://www.chemscene.com/84-22-0.html
ChemMol	49416873	http://www.chemmol.com/chemmol/49416873.html
Chemspace	CSSB00011301665	https://chem-space.com/CSSB00011301665
Finetech	FT-0690208	http://www.finetechnology-ind.com/prod/detail/pub/84-22-0.html
Hairui	HR145170	http://www.hairuichem.com/en/product/84-22-0.html
MedChem Express	HY-B0556	https://www.medchemexpress.com/tetrahydrozoline.html
Molcore	MC573823	https://www.molcore.com/product/84-22-0
OChem	11845	http://www.ocheminc.com/index.php?act=psearch&pid=084T220
Oakwood	373421	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=144909&ExtHyperLink=1
Smolecule	S569467	https://www.smolecule.com/products/s569467
THE BioTek	bt-291936	https://www.thebiotek.com/product/others/bt-291936
Vitas-M Laboratory	STL163582	http://www.request.vitasmlab.com/index.php?option=com_search_stk&Itemid=22&stk=STL163582&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
eNovation Chemicals	D395049	https://www.enovationchem.com/ProductDetails.asp?ProductID=D395049
eNovation Chemicals	D767292	https://www.enovationchem.com/ProductDetails.asp?ProductID=D767292
iChemical	EBD53541	http://www.ichemical.com/chemicals/cas-84-22-0
mcule	MCULE-1878887684	https://mcule.com/MCULE-1878887684/

PubMed

Title	Date	PubMed
Gingival tissue inflammatory response following treatment with chemical retraction agents in Beagle dogs.	2001	11678316
Sinoatrial node arrest following tetrahydrozoline ingestion.	2004 Oct	15388224
Effects of two eye drop products on computer users with subjective ocular discomfort.	2005 Jan	15682562
Ophthalmic delivery systems based on drug-polymer-polymer ionic ternary interaction: in vitro and in vivo characterization.	2006 Jan	16162402
Development of a multicommutated flow system with chemiluminometric detection for quantification of gentamicin in pharmaceuticals.	2010	20981343
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011 Jul 14	21599003

Patents

Sample Use Guides

In Vivo Use Guide

Adults and Children 6 Years and Over, Tyzine 0.1% Nasal Solution: It is recommended that 2 to 4 drops be instilled in each nostril as needed, never more often than every three hours. Adults and Children 6 Years and Over, Tyzine 0.1% Nasal Spray: It is recommended to squeeze quickly and firmly three or four times the spray in each nostril as needed, never more often than every three hours. Children 2 to 6 Years of Age, Tyzine 0.05 % Pediatric Nasal Drops: It is recommended that 2 to 3 drops be instilled in each nostril as needed, and never more often than every three hours.

Route of Administration: Nasal

In Vitro Use Guide

Rat and rabbit aortae were treated with tetrahydrozoline at concentrations from 10(-7) to 10(-5) M to determine the drug relative efficacy. Emax value was 0.51 for the rabbit aortae and 0 for the rat aortae.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:00:45 GMT 2023` Edited by `admin` on `Fri Dec 15 15:00:45 GMT 2023`
Record UNII	0YZT43HS7D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TETRAHYDROZOLINE HYDROCHLORIDE

Common Name

English

TETRAHYDROZOLINE HYDROCHLORIDE [JAN]

Common Name

English

TETRYZOLINE HYDROCHLORIDE [MART.]

Common Name

English

TYZINE

Brand Name

English

TETRAHYDROZOLINE HCL

Common Name

English

Tetryzoline hydrochloride [WHO-DD]

Common Name

English

NSC-757339

Code

English

TETRYZOLINE HYDROCHLORIDE

Common Name

English

YXIN

Brand Name

English

TETRAHYDROZOLINE HYDROCHLORIDE [VANDF]

Common Name

English

TETRAHYDROZOLINE HYDROCHLORIDE [USP MONOGRAPH]

Common Name

English

TETRAHYDROZOLINE HYDROCHLORIDE [MI]

Common Name

English

TETRAHYDROZOLINE HYDROCHLORIDE [USP-RS]

Common Name

English

VISINE

Brand Name

English

TETRAHYDROZOLINE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

TETRYZOLINE HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

RHINOPRONT

Brand Name

English

Classification Tree Code System Code

CFR

21 CFR 349.18