SOLUTE CARRIER FAMILY 12 MEMBER 1

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:51:53 GMT 2025` Edited by `admin` on `Wed Apr 02 05:51:53 GMT 2025`
Protein Type	TRANSPORTER
Protein Sub Type	ION-TRANSPORTER
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	0T7E9VPM81
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SOLUTE CARRIER FAMILY 12 MEMBER 1

Common Name

English

Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1

Preferred Name

English

NKCC2

Common Name

English

SLC12A1

Common Name

English

KIDNEY-SPECIFIC NA-K-CL SYMPORTER

Common Name

English

Code System Code Type Description

PHAROS

Q13621

Created by admin on Wed Apr 02 05:51:53 GMT 2025 , Edited by admin on Wed Apr 02 05:51:53 GMT 2025

PRIMARY

FDA UNII

0T7E9VPM81

Created by admin on Wed Apr 02 05:51:53 GMT 2025 , Edited by admin on Wed Apr 02 05:51:53 GMT 2025

PRIMARY

UNIPROT

Q13621

Created by admin on Wed Apr 02 05:51:53 GMT 2025 , Edited by admin on Wed Apr 02 05:51:53 GMT 2025

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_446
N	1_456

Related Record Type Details


					9L566ML6TH

Bumetanide dibenzylamide

INHIBITOR -> TARGET

Amount:


					DQ6KK6GV93

PIRETANIDE

INHIBITOR -> TARGET

Amount:


					W31X2H97FB

TORSEMIDE

INHIBITOR -> TARGET

Qualification:

POTENCY

Amount:


					7LXU5N7ZO5

FUROSEMIDE

INHIBITOR -> TARGET

Qualification:

POTENCY

Amount:


					M5DP350VZV

ETHACRYNIC ACID

INHIBITOR -> TARGET

Qualification:

POTENCY

Amount:


					MR40VT1L8Z

AZOSEMIDE

INHIBITOR -> TARGET

Amount:


					0Y2S3XUQ5H

Bumetanide

INHIBITOR -> TARGET

Qualification:

POTENCY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_100] [1_105] [1_118]	SITE_SPECIFIC			THREONINE PHOSPHATE	3L4WX7B1EI
AMINO_ACID_SUBSTITUTION	[1_61] [1_120] [1_130] [1_148]	SITE_SPECIFIC			DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL