CLOFIBRIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H22ClNO4
Molecular Weight	327.803
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)C(=O)CCCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1

InChI

InChIKey=CXQGFLBVUNUQIA-UHFFFAOYSA-N

InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C16H22ClNO4
Molecular Weight	327.803
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6105184 | https://www.ncbi.nlm.nih.gov/pubmed/7040821 | https://www.ncbi.nlm.nih.gov/pubmed/862664 | https://www.ncbi.nlm.nih.gov/pubmed/1006320

Clofibride is a hypolipaemic drug of p-chlorophenoxyisobutyric type. Clofibride hypolipaemic effects could be due, partially, to a reduction of hormono-dependent lipolysis. Clofibride decreased blood cholesterol and total lipids, increased liver weight and liver catalase content, and decreased biliary excretion of cholesterol in normolipidemic rats after a 7 day treatment.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Medium and long term study of clofibride in the treatment of atherogenic hyperlipidemia. Statistical approach to the results].	1976 Nov	1006320

Patents

Sample Use Guides

In Vivo Use Guide

Healthy volunteers received therapeutic doses of clofibrate as 2x500 mg capsules, clofibride as 2x450 mg capsules, twice daily for ten days.

Route of Administration: Oral

In Vitro Use Guide

One dose of clofibride (Cf) is administered, after sacrifice of normal fasting rat, in vitro: 2 mg/100 mg adipocytes in 2 ml medium.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:21:17 GMT 2023` Edited by `admin` on `Sat Dec 16 16:21:17 GMT 2023`
Record UNII	0S9SLS3L93
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOFIBRIDE

Official Name

English

CLOFIBRIDE [MART.]

Common Name

English

2-(P-CHLOROPHENOXY)-2-METHYLPROPIONIC ACID, ESTER WITH 4-HYDROXY-N,N-DIMETHYLBUTYRAMIDE

Common Name

English

clofibride [INN]

Common Name

English

Clofibride [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-ATC

C10AB10