Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H24FN9O |
| Molecular Weight | 460.4973 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@]1(CCCN1C2=NN3C=CC=C3C(NC4=NNC(=C4)C5CC5)=N2)C(=O)NC6=CN=C([18F])C=C6
InChI
InChIKey=LQVXSNNAFNGRAH-SXBFPYQPSA-N
InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1/i24-1
| Molecular Formula | C23H24FN9O |
| Molecular Weight | 460.4973 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including http://jnm.snmjournals.org/content/53/supplement_1/1558.abstract?related-urls=yes&legid=jnumed;53/supplement_1/1558
Curator's Comment: Description was created based on several sources, including http://jnm.snmjournals.org/content/53/supplement_1/1558.abstract?related-urls=yes&legid=jnumed;53/supplement_1/1558
BMS-754807 is an orally bioavailable, potent and reversible small molecule inhibitor of the IGF-1R/IR family kinases with Ki <2 nmol/L. BMS-754807 could effectively inhibit the growth of many human tumor types from in vitro perspective, such as mesenchymal, hematopoietic and epithelial tumor cell lines with an IC50 value of 5–365 nmol/L. BMS-754807 F-18 is the first small molecule radioligand that showed promise for imaging IGF-1R in tumor/ cancer. The results indicate that BMS-754807 F-18 can be a potential PET imaging agent for in vivo monitoring IGF-1R.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:27:09 GMT 2023
by
admin
on
Sat Dec 16 09:27:09 GMT 2023
|
| Record UNII |
0S131V9ZZZ
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
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| Code System | Code | Type | Description | ||
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300000038518
Created by
admin on Sat Dec 16 09:27:09 GMT 2023 , Edited by admin on Sat Dec 16 09:27:09 GMT 2023
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71713629
Created by
admin on Sat Dec 16 09:27:09 GMT 2023 , Edited by admin on Sat Dec 16 09:27:09 GMT 2023
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1446701-47-8
Created by
admin on Sat Dec 16 09:27:09 GMT 2023 , Edited by admin on Sat Dec 16 09:27:09 GMT 2023
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0S131V9ZZZ
Created by
admin on Sat Dec 16 09:27:09 GMT 2023 , Edited by admin on Sat Dec 16 09:27:09 GMT 2023
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PRIMARY |
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NON-LABELED -> LABELED |
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