Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C18H34O2.C12H26N4O6 |
Molecular Weight | 604.8194 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 10 / 10 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCC\C=C/CCCCCCCC(O)=O.[H][C@]2(O[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O)O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N
InChI
InChIKey=DZJNRUAMSDNLDC-AWCLPILZSA-N
InChI=1S/C18H34O2.C12H26N4O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h9-10H,2-8,11-17H2,1H3,(H,19,20);3-12,17-20H,1-2,13-16H2/b10-9-;/t;3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m.1/s1
Molecular Formula | C12H26N4O6 |
Molecular Weight | 322.358 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 10 / 10 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | C18H34O2 |
Molecular Weight | 282.4614 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Screening for new compounds with antiherpes activity. | 1984 Oct |
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Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. | 1993 Sep 24 |
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Study of aminoglycoside-nucleic acid interactions by an HPLC method. | 2001 Apr 23 |
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Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. | 2001 Feb 26 |
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An efficient synthesis of mimetics of neamine for RNA recognition. | 2001 May 31 |
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Design of novel antibiotics that bind to the ribosomal acyltransfer site. | 2002 Apr 3 |
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Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide. | 2003 Feb 28 |
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Voltage-dependent inhibition of rat skeletal muscle sodium channels by aminoglycoside antibiotics. | 2004 May |
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Structure-activity relationships of aminoglycoside-arginine conjugates that bind HIV-1 RNAs as determined by fluorescence and NMR spectroscopy. | 2004 Nov 19 |
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Chemoenzymatic synthesis and high-throughput screening of an aminoglycoside-polyamine library: identification of high-affinity displacers and DNA-binding ligands. | 2004 Oct 6 |
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A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication. | 2004 Sep 23 |
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Disaccharide mimetics of the aminoglycoside antibiotic neamine. | 2004 Sep 6 |
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Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. | 2005 Apr 15 |
|
Neamine inhibits xenografic human tumor growth and angiogenesis in athymic mice. | 2005 Dec 15 |
|
The RNA-bound conformation of neamine as determined by transferred NOE experiments. | 2005 Jul |
|
Neamine dimers targeting the HIV-1 TAR RNA. | 2005 Nov 1 |
|
Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR-Tat. | 2006 Apr 15 |
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Synthesis and antibacterial activity of novel neamine derivatives. | 2006 Dec 15 |
|
Cationic polyamines inhibit anthrax lethal factor protease. | 2006 Jun 8 |
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Determination of tobramycin and impurities using high-performance anion exchange chromatography with integrated pulsed amperometric detection. | 2006 Mar 3 |
|
Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. | 2006 Oct 1 |
|
Design and synthesis of a structurally constrained aminoglycoside. | 2007 Jul 6 |
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Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. | 2007 Jun 1 |
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Synthesis of a neamine dimer targeting the dimerization initiation site of HIV-1 RNA. | 2007 Oct 25 |
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Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. | 2008 Aug 20 |
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Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions. | 2008 Dec 2 |
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Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption. | 2008 Feb |
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Fluorescence correlation spectroscopy at single molecule level on the Tat-TAR complex and its inhibitors. | 2008 Jan |
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Enantioseparation by MEKC using a ligand exchange-based chiral pseudostationary phase. | 2009 Aug |
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Search for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoring. | 2009 Feb |
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Chiral ligand-exchange chromatography of amino acids using porous graphitic carbon coated with a dinaphthyl derivative of neamine. | 2009 Jan |
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Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations. | 2009 Oct 21 |
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The nebramycin aminoglycoside profiles of Streptomyces tenebrarius and their characterization using an integrated liquid chromatography-electrospray ionization-tandem mass spectrometric analysis. | 2010 Feb 19 |
|
Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin-, and neamine-based amphiphiles with potent broad spectrum antibacterial activity. | 2010 May 13 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:03:33 GMT 2023
by
admin
on
Fri Dec 15 15:03:33 GMT 2023
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Record UNII |
0S0TGD9Q4H
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Record Status |
Validated (UNII)
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Record Version |
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123133436
Created by
admin on Fri Dec 15 15:03:33 GMT 2023 , Edited by admin on Fri Dec 15 15:03:33 GMT 2023
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0S0TGD9Q4H
Created by
admin on Fri Dec 15 15:03:33 GMT 2023 , Edited by admin on Fri Dec 15 15:03:33 GMT 2023
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PRIMARY |
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PARENT -> SALT/SOLVATE |