SOTATERCEPT

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 20:44:09 GMT 2025` Edited by `admin` on `Mon Mar 31 20:44:09 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	0QI90BTJ37
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

ACE011

Preferred Name

English

SOTATERCEPT

Official Name

English

Sotatercept [WHO-DD]

Common Name

English

(HUMAN ACTIVIN RECEPTOR TYPE-2A PRECURSOR-(21-135)-PEPTIDYL)-THREONYLTRIGLYCYL-(HUMAN IMMUNOGLOBULIN HEAVY CONSTANT .GAMMA.1 FC FRAGMENT: (8-15)-HINGE-(A-100>V)-CH2-CH3 OF HOMO SAPIENS IGHG1*03), (123-123':126-126')-BISDISULFIDE DIMER

Common Name

English

sotatercept [INN]

Common Name

English

SOTATERCEPT [USAN]

Common Name

English

(HUMAN ACTIVIN RECEPTOR TYPE-2A PRECURSOR-(21-135)-PEPTIDYL)-THREONYLTRIGLYCYL-(HUMAN IMMUNOGLOBULIN HEAVY CONSTANT .GAMMA.1 FC FRAGMENT: (8-15)-HINGE-(A-100>V)-CH2-CH3 OF HOMO SAPIENS IGHG1*03), (123-123':126-126')-BISDISULPHIDE DIMER

Common Name

English

ACTIVIN RECEPTOR TYPE IIA (SYNTHETIC HUMAN EXTRACELLULAR DOMAIN-CONTAINING FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (SYNTHETIC HUMAN HEAVY CHAIN FC FRAGMENT), DIMER

Common Name

English

ACE-011

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

700219

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

FDA ORPHAN DRUG

387112

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

FDA ORPHAN DRUG

389813

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

FDA ORPHAN DRUG

413713

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

FDA ORPHAN DRUG

428614

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

NCI_THESAURUS

C1512

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C80038

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

CAS

1001080-50-7

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

DAILYMED

0QI90BTJ37

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

FDA UNII

0QI90BTJ37

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

SMS_ID

100000175015

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

USAN

UU-106

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

ChEMBL

CHEMBL1743073

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

INN

9188

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

DRUG BANK

DB12118

Created by admin on Mon Mar 31 20:44:09 GMT 2025 , Edited by admin on Mon Mar 31 20:44:09 GMT 2025

PRIMARY

From	To
1_10	1_40
1_30	1_58
1_65	1_84
1_71	1_83
1_85	1_90
1_123	2_123
1_126	2_126
1_158	1_218
1_264	1_322
2_10	2_40
2_30	2_58
2_65	2_84
2_71	2_83
2_85	2_90
2_158	2_218
2_264	2_322

Glycosylation Link Type	Site
N	1_23
N	1_46
N	1_194
N	2_23
N	2_46
N	2_194

Related Record Type Details


					Y7EVZ2AC23

SMAD 3

TARGET -> INHIBITOR

Amount:


					9YB1YO75HY

SMAD-2

TARGET -> INHIBITOR

Amount:

Sotatercept-CSRK

SUB_CONCEPT->SUBSTANCE

Amount:

Related Record Type Details


					0QI90BTJ37

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:FORMULA	CHEMICAL