JNJ-41443532

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25F3N4O3S
Molecular Weight	482.519
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@]1(CC[C@@H](CC1)N2CC(C2)NC(=O)CNC(=O)C3=CC=CC(=C3)C(F)(F)F)C4=CN=CS4

InChI

InChIKey=CFKBNYUHQSQBSX-CYWCHRQTSA-N

InChI=1S/C22H25F3N4O3S/c23-22(24,25)15-3-1-2-14(8-15)20(31)27-10-19(30)28-16-11-29(12-16)17-4-6-21(32,7-5-17)18-9-26-13-33-18/h1-3,8-9,13,16-17,32H,4-7,10-12H2,(H,27,31)(H,28,30)/t17-,21-

HIDE SMILES / InChI

Molecular Formula	C22H25F3N4O3S
Molecular Weight	482.519
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24798870 | https://clinicaltrials.gov/ct2/show/record/NCT01230749

JNJ-41443532 is a C-C motif chemokine receptor 2 antagonist. It is under development for the treatment of type 2 diabetes.

Originator

Approval Year

PubMed

Title	Date	PubMed
CCR2 antagonism in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study.	2014-11	24798870

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:53:45 GMT 2025` Edited by `admin` on `Mon Mar 31 22:53:45 GMT 2025`
Record UNII	0OJB0LES1A
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BENZAMIDE, N-(2-((1-(TRANS-4-HYDROXY-4-(5-THIAZOLYL)CYCLOHEXYL)-3-AZETIDINYL)AMINO)-2-OXOETHYL)-3-(TRIFLUOROMETHYL)

Preferred Name

English

JNJ-41443532

Common Name

English

Code System Code Type Description

CAS

1228650-83-6