STANNSOPORFIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C34H36N4O4.2Cl.Sn
Molecular Weight	754.29
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].[Cl-].[Sn+4].CCC1=C(C)C2=CC3=C(CC)C(C)=C([N-]3)C=C4N=C(C=C5[N-]C(=CC1=N2)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C

InChI

InChIKey=LLDZJTIZVZFNCM-UHEVNVKKSA-J

InChI=1S/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;

HIDE SMILES / InChI

Molecular Formula	Cl
Molecular Weight	35.453
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C34H36N4O4
Molecular Weight	564.674
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Sn
Molecular Weight	118.71
Charge	4
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2714739 | https://www.ncbi.nlm.nih.gov/pubmed/2531365 | https://www.ncbi.nlm.nih.gov/pubmed/12846900

Stannsoporfin is a mesoporphyrin derivative patented by Rockefeller University as competitive heme oxygenase (HO) inhibitor for the prevention of hyperbilirubinemia in infants at risk of developing jaundice. Parenteral administration of Stannsoporfin has been shown to suppress or moderate jaundice in a wide variety of experimental and naturally occurring forms of hyperbilirubinemia in animals and man. Stannsoporfin is rapidly cleared from the plasma in animals, in adult humans, and in newborn infants and may inhibit competitive heme oxygenase for prolonged periods. The Stannsoporfin decreases the production of carbon monoxide from heme and increases the biliary excretion of unmetabolized heme but has no effect on the metabolic disposition of preformed bilirubin.

Originator

Approval Year

PubMed

Title	Date	PubMed
Inhibition of hippocampal heme oxygenase, nitric oxide synthase, and long-term potentiation by metalloporphyrins.	1994 Nov	7524564
Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress.	2008 Dec 12	18852027
Protein assay for heme oxygenase-1 (HO-1) induced by chemicals in HepG2 cells.	2009 Dec	19952508
Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21.	2014 Mar	23839791

Patents

Sample Use Guides

In Vivo Use Guide

0.1-1.0 mkM/kg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:48:27 GMT 2023` Edited by `admin` on `Sat Dec 16 17:48:27 GMT 2023`
Record UNII	0KAE1U0G7Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

STANNSOPORFIN

Official Name

English

(OC-6-13)-DIHYDROGEN DICHLORO(7,12-DIETHYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOATO(4-)-N(SUP 21),N(SUP 22),N(SUP 23),N(SUP 24))STANNATE(2-)

Common Name

English

TIN MESOPORPHYRIN

Common Name

English

B-992

Code

English

B992

Code

English

STANNSOPORFIN [USAN]

Common Name

English

MESOPORPHYRIN TIN

Common Name

English

stannsoporfin [INN]

Common Name

English

Stannsoporfin [WHO-DD]

Common Name

English

STANATE

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471