Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C34H36N4O4.2Cl.Sn |
| Molecular Weight | 754.29 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].[Cl-].[Sn+4].CCC1=C(C)C2=CC3=C(CC)C(C)=C([N-]3)C=C4N=C(C=C5[N-]C(=CC1=N2)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C
InChI
InChIKey=LLDZJTIZVZFNCM-UHEVNVKKSA-J
InChI=1S/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;
| Molecular Formula | Cl |
| Molecular Weight | 35.453 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C34H36N4O4 |
| Molecular Weight | 564.674 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Sn |
| Molecular Weight | 118.71 |
| Charge | 4 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Stannsoporfin is a mesoporphyrin derivative patented by Rockefeller University as competitive heme oxygenase (HO) inhibitor for the prevention of hyperbilirubinemia in infants at risk of developing jaundice. Parenteral administration of Stannsoporfin has been shown to suppress or moderate jaundice in a wide variety of experimental and naturally occurring forms of hyperbilirubinemia in animals and man. Stannsoporfin is rapidly cleared from the plasma in animals, in adult humans, and in newborn infants and may inhibit competitive heme oxygenase for prolonged periods. The Stannsoporfin decreases the production of carbon monoxide from heme and increases the biliary excretion of unmetabolized heme but has no effect on the metabolic disposition of preformed bilirubin.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibition of hippocampal heme oxygenase, nitric oxide synthase, and long-term potentiation by metalloporphyrins. | 1994 Nov |
|
| Astroglial cytoprotection by erythropoietin pre-conditioning: implications for ischemic and degenerative CNS disorders. | 2005 Apr |
|
| Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes. | 2005 Aug |
|
| Heme oxygenase-2 deficiency contributes to diabetes-mediated increase in superoxide anion and renal dysfunction. | 2006 Apr |
|
| Heme oxygenase-1 enhances renal mitochondrial transport carriers and cytochrome C oxidase activity in experimental diabetes. | 2006 Jun 9 |
|
| Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation. | 2010 May |
|
| Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: a role of heme oxygenase. | 2012 Jan 27 |
|
| Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: a role of heme oxygenase-1. | 2013 Jun 7 |
|
| Up-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept. | 2014 Apr 5 |
|
| Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. | 2014 Mar |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sun Dec 18 20:52:38 UTC 2022
by
admin
on
Sun Dec 18 20:52:38 UTC 2022
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| Record UNII |
0KAE1U0G7Q
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C471
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SUB04555MIG
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C152424
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DB04912
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JJ-34
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7752
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0KAE1U0G7Q
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106344-20-1
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C055421
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16686132
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