TIOXACIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H12N2O4S
Molecular Weight	304.321
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C=C(C(O)=O)C(=O)C2=C1C=CC3=C2SC(=O)N3C

InChI

InChIKey=VUUPJGYIOAVFAN-UHFFFAOYSA-N

InChI=1S/C14H12N2O4S/c1-3-16-6-7(13(18)19)11(17)10-8(16)4-5-9-12(10)21-14(20)15(9)2/h4-6H,3H2,1-2H3,(H,18,19)

HIDE SMILES / InChI

Molecular Formula	C14H12N2O4S
Molecular Weight	304.321
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/544774 | Katritzky, A.R. (2001) Advances in Heterocyclic Chemistry, v.78, page 206, retrieved from: https://books.google.ru/books?id=AMgNoaMyUQkC

Tioxacin is a bactericide agent. Tioxacin gives a soluble complex with aliphatic amines and had the highest activities against G(+) and G (-) bacteria, including Escherichia coli resistant to nalidixic acid and Pseudomonas aeruginosa from 98 acids of this type. Absorption studies in dogs suggested that the amine complex may have a great utility as a rapid dissolving form of tioxacin in oral administration.

Approval Year

PubMed

Title	Date	PubMed
[Soluble complex formation of 6-ethyl-2,3,6,9-tetrahydro-3-methyl-2,9-dioxothiazolo-[5,4-f]quinoline-8-carboxylic acid (tioxacin) with aliphatic amines (author's transl)].	1979-05	544774

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:59:30 GMT 2025` Edited by `admin` on `Mon Mar 31 17:59:30 GMT 2025`
Record UNII	0K40CNM74K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TIOXACIN

Official Name

English

TIOXACIN [JAN]

Preferred Name

English

tioxacin [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C795