NICOTINAMIDE RIBOSIDE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H15N2O5
Molecular Weight	255.2472
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1=C[N+](=CC=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

InChI

InChIKey=JLEBZPBDRKPWTD-TURQNECASA-O

InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C11H14N2O5
Molecular Weight	254.2393
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
NAD-dependent deacetylase sirtuin 1 19 Target ID: CHEMBL4506 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27732834	Activator 1447

C_max

Value	Dose	Co-administered	Analyte	Population
0.05 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29211728/	1000 mg 2 times / day steady-state, oral dose: 1000 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		NICOTINAMIDE RIBOSIDE blood	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
0.48 μM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29211728/	1000 mg 2 times / day steady-state, oral dose: 1000 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		NICOTINAMIDE RIBOSIDE blood	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29211728/	1000 mg 2 times / day steady-state, oral dose: 1000 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		NICOTINAMIDE RIBOSIDE blood	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

PubMed

Title	Date	PubMed
Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis.	2016-10-11	27732834

Substance Class	Chemical Created by `admin` on `Tue Apr 01 20:41:28 GMT 2025` Edited by `admin` on `Tue Apr 01 20:41:28 GMT 2025`
Record UNII	0I8H2M0L7N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NICOTINAMIDE RIBOSIDE

Common Name

English

NICOTINAMIDE RIBONUCLEOSIDE

Preferred Name

English

NICOTINAMIDE RIBOSE

Systematic Name

English

RIBOSYLNICOTINAMIDE

Common Name

English

PYRIDINIUM, 3-(AMINOCARBONYL)-1-.BETA.-D-RIBOFURANOSYL-

Systematic Name

English

Nicotinamide riboside [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

628218