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Details

Stereochemistry ACHIRAL
Molecular Formula C21H27NO2
Molecular Weight 325.4446
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETAFENONE

SMILES

CCN(CC)CCOC1=CC=CC=C1C(=O)CCC2=CC=CC=C2

InChI

InChIKey=OEGDFSLNGABBKJ-UHFFFAOYSA-N
InChI=1S/C21H27NO2/c1-3-22(4-2)16-17-24-21-13-9-8-12-19(21)20(23)15-14-18-10-6-5-7-11-18/h5-13H,3-4,14-17H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C21H27NO2
Molecular Weight 325.4446
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Etafenone is an antiarrhythmic and coronary vasodilator drug. Etafenone exerts negative inotropic action on myocardium. It is able to block calcium channels. As a coronary vasodilator which produces a decrease in the heart rate and myocardial oxygen consumption, etafenone has been used in the therapy of ischemic heart disease.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
2.43 µM [Ki]
3.92 µM [Ki]
0.184 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DIALICOR

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Parenteral
In Vitro Use Guide
After etafenone 1 uM, there was a significant prolongation of the time to the detectable or the maximum increase in NADH fluorescence in isolated perfused guinea pig heart
Substance Class Chemical
Record UNII
0I14K589E7
Record Status Validated (UNII)
Record Version