U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C4H10O
Molecular Weight 74.1216
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHER

SMILES

CCOCC

InChI

InChIKey=RTZKZFJDLAIYFH-UHFFFAOYSA-N
InChI=1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C4H10O
Molecular Weight 74.1216
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Diethyl ether (ether) had been widely used for anesthesia until the 1960s despite its explosive properties and toxicity to both humans and animals. Diethyl ether still serves a role today as an effective inhalation agent. Newer inhalation agents have replaced ether completely and open drop delivery systems have been exchanged for complicated vaporizers and monitoring systems. Anesthesia in the developing world, however, still closely resembles primitive anesthetics.

Originator

Curator's Comment: Ether (diethyl ether) was first prepared in 1540 by Valerius Cordus, a Prussian botanist

Approval Year

Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Effects of fractions from biodegraded Alaska North Slope crude oil on embryonic inland silversides, Menidia beryllina.
2002-02
Oxabicyclo[3.2.1]octenes in organic synthesis: direct ring opening of oxabicyclo[3.2.1] ring systems with diisobutylaluminum hydride and a silyl ketene acetal--synthesis of the chiral C(19)-C(26) and C(27)-C(32) fragments of Scytophycin C.
2002-01-24
Use of enzyme-immunoassay for oestradiol-17beta and progesterone quantification in canine serum.
2002-01-23
Fluorescent labeling of drugs and simple organic compounds containing amine functional groups, utilizing dansyl chloride in Na(2)CO(3) buffer.
2002-01-05
An in vivo rat model for assessment of extrahepatic metabolism.
2002-01-05
HPLC analysis of 4-chlorophenyl methyl sulphide and diphenyl sulphide and their corresponding sulphoxides and sulphones in rat liver microsomes.
2002-01-01
Perinatal maternal food restriction induces alterations in hypothalamo-pituitary-adrenal axis activity and in plasma corticosterone-binding globulin capacity of weaning rat pups.
2002-01
The inhibitory effects of anesthetics and ethanol on substance P receptors expressed in Xenopus oocytes.
2002-01
Optimisation of transgene action at the post-transcriptional level: high quality parthenocarpic fruits in industrial tomatoes.
2002
Monomeric and dimeric amidinate complexes of magnesium.
2001-12-03
Quantification of nimesulide in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Application to bioequivalence studies.
2001-12
RP-HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies.
2001-12
The effect of Nepeta cataria extract on adherence and enzyme production of Staphylococcus aureus.
2001-12
Components of the 2f(1)-f(2) distortion-product otoacoustic emission in a moth.
2001-12
Phenolic extracts from meadowsweet and hawthorn flowers have antioxidative properties.
2001-11-29
Preparation of acetylated pyranoid glycals from glycosyl halides by chromium(II) complexes under aqueous biphasic conditions.
2001-11-21
Synthesis and properties of the tetrakis(trifluoromethyl)borate anion, [b(CF3)4]-: structure determination of Cs[B(CF3)4] by single-crystal X-ray diffraction.
2001-11-05
Determination of cyclosporin A in human and mouse plasma by reversed-phase high-performance liquid chromatography.
2001-11-05
Optical determination of low-level water concentrations in organic solvents using fluorescent acridinyl dyes and dye-immobilized polymer membranes.
2001-11-01
Biodegradation of methyl tert-butyl ether under various substrate conditions.
2001-11-01
Effects of chronic experimental alcoholism on the epithelium of the uterine horn of rats (Rattus norvegicus albinus).
2001-11-01
Extracts of Flourensia cernua reduce consumption of alfalfa pellets by sheep.
2001-11
Extracts of Flourensia cernua (L): volatile constituents and antifungal, antialgal, and antitermite bioactivities.
2001-11
Monitoring method for airborne glymes and its application in fuel exhaust emission measurement.
2001-11
LC determination of the anti-ischemic and anti-hypertensive agent CDRI-93/478 in rat serum.
2001-11
Modification of photosystem I reaction center by the extraction and exchange of chlorophylls and quinones.
2001-10-30
Validation of an analytical method for a potent antitumor agent, TZT-1027, in plasma using liquid chromatography-mass spectrometry.
2001-10-25
Kinetic and product studies of the reactions of selected glycol ethers with OH radicals.
2001-10-15
Adsorption study of alkyl-silicas and methylsiloxy-silicas.
2001-10-05
Use of odorless thiols: formal asymmetric Michael addition of hydrogen sulfide to alpha-substituted alpha,beta-unsaturated carbonyl compounds.
2001-10-04
Measurement of ketoprofen in horse urine using gas chromatography-mass spectrometry.
2001-10
Determination of nandrolone and metabolites in urine samples from sedentary persons and sportsmen.
2001-09-25
A crystalline diethyl ether adduct of tetrafluorogermane.
2001-09-24
Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of L-rhodinosyl acetate derivatives.
2001-09-21
Changes in lipids and sterols during composting.
2001-09
Separation and determination of ephedrine alkaloids and tetramethylpyrazine in Ephedra sinica Stapf by gas chromatography-mass spectrometry.
2001-09
Resolution by polarographic techniques of the ternary mixture of captan, captafol and folpet by using PLS calibration and artificial neuronal networks.
2001-09
Microbial degradation and fate in the environment of methyl tert-butyl ether and related fuel oxygenates.
2001-08
Structure and ultrastructure of the ventral prostate of isogenic mice (C57B1/6J) submitted to chronic alcohol ingestion.
2001-08
Purification and stabilization of 99mTc-d,l-HMPAO: role of organic extractants.
2001-08
A synthesis of 3-phenyl-1,2,3,4-tetrahydroisoquinoline and 2-phenyl-1,2,4,5-tetrahydro-3H-3-benzazepine via Pummerer-type cyclization: enhancing effect of boron trifluoride diethyl etherate on the cyclization.
2001-08
Comparison of extraction methods to monitor pesticide residues in surface water.
2001-08
Purification of saponin compounds in Bupleurum falcatum by solvent partitioning and preparative LC.
2001-07
Human cytochrome P450 isozymes in metabolism and health effects of gasoline ethers.
2001-05
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272.
2001
Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens.
2001
[Lipase-catalyzed kinetic resolution of 2-substituted cycloalkanols].
2001
Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels.
2001
Stratum corneum lipids liposomes for the topical delivery of 5-aminolevulinic acid in photodynamic therapy of skin cancer: preparation and in vitro permeation study.
2001
Plasma melatonin levels in relation to the light-dark cycle and parental background in domestic pigs.
2001
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:34:59 GMT 2025
Edited
by admin
on Mon Mar 31 18:34:59 GMT 2025
Record UNII
0F5N573A2Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETHER
EP   HSDB   II   USP   VANDF  
Common Name English
Ethyl ether
INCI   MI   WHO-DD  
INCI  
Preferred Name English
ETHOXYETHANE
Systematic Name English
ETHER [VANDF]
Common Name English
ETHER [EP MONOGRAPH]
Common Name English
SOLVENT ETHER [MART.]
Common Name English
PRONARCOL
Common Name English
ETHYL ETHER [MI]
Common Name English
ETHERUM [HPUS]
Common Name English
ANAESTHETIC ETHER [WHO-IP]
Common Name English
ETHANE, 1,1'-OXYBIS-
Systematic Name English
ETHER [JAN]
Common Name English
DIETHYL ETHER
Systematic Name English
ETHYL OXIDE
Systematic Name English
ETHER [HSDB]
Common Name English
ETHERUM
HPUS  
Common Name English
Ethyl ether [WHO-DD]
Common Name English
ETHER ANAESTHESICUS [WHO-IP LATIN]
Common Name English
ETHER [USP MONOGRAPH]
Common Name English
NSC-100036
Code English
ETHER [II]
Common Name English
Classification Tree Code System Code
WHO-ATC N01AA01
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
NCI_THESAURUS C802
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
DEA NO. 6584
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
WHO-VATC QN01AA01
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
Code System Code Type Description
SMS_ID
100000076354
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
CHEBI
25698
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
CAS
60-29-7
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
HSDB
70
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
DRUG CENTRAL
4417
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ETHER
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY Description: A clear, colourless, volatile, very mobile liquid; odour, characteristic. Miscibility: Miscible with 10 parts of water; miscible with ethanol (~750 g/l) TS. Category: General anaesthetic. Storage: Anaesthetic Ether should be kept in a securely closed, dry container, protected from light, at a temperature not exceeding 15 ?C, and in quantities of not more than 1 kg. Labelling: The designation on the container of anaesthetic Ether must state: "Highly flammable. Do not use near an open flame orother sources of heat that may cause ignition." The name and quantity of any antioxidant added must be stated. Additional information: Anaesthetic Ether may contain a suitable antioxidant. It must not be used for anaesthesia if it has been removed from its original container for longer than 24 hours. Ether remaining in partially used containers may deteriorate rapidly. CAUTION: Vapours of ether mixed with air, oxygen, or nitrous oxide in certain concentrations are explosive. Do not use an open flame at any time during the testing procedure.
DAILYMED
0F5N573A2Y
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
WIKIPEDIA
DIETHYL ETHER
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
NCI_THESAURUS
C29819
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
RXCUI
1363043
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY RxNorm
NSC
100036
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
FDA UNII
0F5N573A2Y
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
EPA CompTox
DTXSID3021720
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
DRUG BANK
DB13598
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
EVMPD
SUB11948MIG
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
EVMPD
SUB11949MIG
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
EVMPD
SUB36361
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
ChEMBL
CHEMBL16264
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
CHEBI
35702
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
PUBCHEM
3283
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-467-2
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY
MERCK INDEX
m5131
Created by admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
PRIMARY Merck Index
Related Record Type Details
ACTIVE MOIETY