Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H10O |
| Molecular Weight | 74.1216 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOCC
InChI
InChIKey=RTZKZFJDLAIYFH-UHFFFAOYSA-N
InChI=1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3
| Molecular Formula | C4H10O |
| Molecular Weight | 74.1216 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Diethyl ether (ether) had been widely used for anesthesia until the 1960s despite its explosive properties and toxicity to both humans and animals. Diethyl ether still serves a role today as an effective inhalation agent. Newer inhalation agents have replaced ether completely and open drop delivery systems have been exchanged for complicated vaporizers and monitoring systems. Anesthesia in the developing world, however, still closely resembles primitive anesthetics.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26475128
Curator's Comment: Ether (diethyl ether) was first prepared in 1540 by Valerius Cordus, a Prussian botanist
Approval Year
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
Drug as perpetrator
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/3340079/ |
yes |
Drug as victim
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
| yes |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of fractions from biodegraded Alaska North Slope crude oil on embryonic inland silversides, Menidia beryllina. | 2002-02 |
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| Oxabicyclo[3.2.1]octenes in organic synthesis: direct ring opening of oxabicyclo[3.2.1] ring systems with diisobutylaluminum hydride and a silyl ketene acetal--synthesis of the chiral C(19)-C(26) and C(27)-C(32) fragments of Scytophycin C. | 2002-01-24 |
|
| Use of enzyme-immunoassay for oestradiol-17beta and progesterone quantification in canine serum. | 2002-01-23 |
|
| Fluorescent labeling of drugs and simple organic compounds containing amine functional groups, utilizing dansyl chloride in Na(2)CO(3) buffer. | 2002-01-05 |
|
| An in vivo rat model for assessment of extrahepatic metabolism. | 2002-01-05 |
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| HPLC analysis of 4-chlorophenyl methyl sulphide and diphenyl sulphide and their corresponding sulphoxides and sulphones in rat liver microsomes. | 2002-01-01 |
|
| Perinatal maternal food restriction induces alterations in hypothalamo-pituitary-adrenal axis activity and in plasma corticosterone-binding globulin capacity of weaning rat pups. | 2002-01 |
|
| The inhibitory effects of anesthetics and ethanol on substance P receptors expressed in Xenopus oocytes. | 2002-01 |
|
| Optimisation of transgene action at the post-transcriptional level: high quality parthenocarpic fruits in industrial tomatoes. | 2002 |
|
| Monomeric and dimeric amidinate complexes of magnesium. | 2001-12-03 |
|
| Quantification of nimesulide in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Application to bioequivalence studies. | 2001-12 |
|
| RP-HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies. | 2001-12 |
|
| The effect of Nepeta cataria extract on adherence and enzyme production of Staphylococcus aureus. | 2001-12 |
|
| Components of the 2f(1)-f(2) distortion-product otoacoustic emission in a moth. | 2001-12 |
|
| Phenolic extracts from meadowsweet and hawthorn flowers have antioxidative properties. | 2001-11-29 |
|
| Preparation of acetylated pyranoid glycals from glycosyl halides by chromium(II) complexes under aqueous biphasic conditions. | 2001-11-21 |
|
| Synthesis and properties of the tetrakis(trifluoromethyl)borate anion, [b(CF3)4]-: structure determination of Cs[B(CF3)4] by single-crystal X-ray diffraction. | 2001-11-05 |
|
| Determination of cyclosporin A in human and mouse plasma by reversed-phase high-performance liquid chromatography. | 2001-11-05 |
|
| Optical determination of low-level water concentrations in organic solvents using fluorescent acridinyl dyes and dye-immobilized polymer membranes. | 2001-11-01 |
|
| Biodegradation of methyl tert-butyl ether under various substrate conditions. | 2001-11-01 |
|
| Effects of chronic experimental alcoholism on the epithelium of the uterine horn of rats (Rattus norvegicus albinus). | 2001-11-01 |
|
| Extracts of Flourensia cernua reduce consumption of alfalfa pellets by sheep. | 2001-11 |
|
| Extracts of Flourensia cernua (L): volatile constituents and antifungal, antialgal, and antitermite bioactivities. | 2001-11 |
|
| Monitoring method for airborne glymes and its application in fuel exhaust emission measurement. | 2001-11 |
|
| LC determination of the anti-ischemic and anti-hypertensive agent CDRI-93/478 in rat serum. | 2001-11 |
|
| Modification of photosystem I reaction center by the extraction and exchange of chlorophylls and quinones. | 2001-10-30 |
|
| Validation of an analytical method for a potent antitumor agent, TZT-1027, in plasma using liquid chromatography-mass spectrometry. | 2001-10-25 |
|
| Kinetic and product studies of the reactions of selected glycol ethers with OH radicals. | 2001-10-15 |
|
| Adsorption study of alkyl-silicas and methylsiloxy-silicas. | 2001-10-05 |
|
| Use of odorless thiols: formal asymmetric Michael addition of hydrogen sulfide to alpha-substituted alpha,beta-unsaturated carbonyl compounds. | 2001-10-04 |
|
| Measurement of ketoprofen in horse urine using gas chromatography-mass spectrometry. | 2001-10 |
|
| Determination of nandrolone and metabolites in urine samples from sedentary persons and sportsmen. | 2001-09-25 |
|
| A crystalline diethyl ether adduct of tetrafluorogermane. | 2001-09-24 |
|
| Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of L-rhodinosyl acetate derivatives. | 2001-09-21 |
|
| Changes in lipids and sterols during composting. | 2001-09 |
|
| Separation and determination of ephedrine alkaloids and tetramethylpyrazine in Ephedra sinica Stapf by gas chromatography-mass spectrometry. | 2001-09 |
|
| Resolution by polarographic techniques of the ternary mixture of captan, captafol and folpet by using PLS calibration and artificial neuronal networks. | 2001-09 |
|
| Microbial degradation and fate in the environment of methyl tert-butyl ether and related fuel oxygenates. | 2001-08 |
|
| Structure and ultrastructure of the ventral prostate of isogenic mice (C57B1/6J) submitted to chronic alcohol ingestion. | 2001-08 |
|
| Purification and stabilization of 99mTc-d,l-HMPAO: role of organic extractants. | 2001-08 |
|
| A synthesis of 3-phenyl-1,2,3,4-tetrahydroisoquinoline and 2-phenyl-1,2,4,5-tetrahydro-3H-3-benzazepine via Pummerer-type cyclization: enhancing effect of boron trifluoride diethyl etherate on the cyclization. | 2001-08 |
|
| Comparison of extraction methods to monitor pesticide residues in surface water. | 2001-08 |
|
| Purification of saponin compounds in Bupleurum falcatum by solvent partitioning and preparative LC. | 2001-07 |
|
| Human cytochrome P450 isozymes in metabolism and health effects of gasoline ethers. | 2001-05 |
|
| NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272. | 2001 |
|
| Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens. | 2001 |
|
| [Lipase-catalyzed kinetic resolution of 2-substituted cycloalkanols]. | 2001 |
|
| Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels. | 2001 |
|
| Stratum corneum lipids liposomes for the topical delivery of 5-aminolevulinic acid in photodynamic therapy of skin cancer: preparation and in vitro permeation study. | 2001 |
|
| Plasma melatonin levels in relation to the light-dark cycle and parental background in domestic pigs. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:34:59 GMT 2025
by
admin
on
Mon Mar 31 18:34:59 GMT 2025
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| Record UNII |
0F5N573A2Y
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| Record Status |
Validated (UNII)
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| Record Version |
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WHO-ATC |
N01AA01
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NCI_THESAURUS |
C802
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DEA NO. |
6584
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WHO-VATC |
QN01AA01
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100000076354
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25698
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60-29-7
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70
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4417
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ETHER
Created by
admin on Mon Mar 31 18:34:59 GMT 2025 , Edited by admin on Mon Mar 31 18:34:59 GMT 2025
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PRIMARY | Description: A clear, colourless, volatile, very mobile liquid; odour, characteristic. Miscibility: Miscible with 10 parts of water; miscible with ethanol (~750 g/l) TS. Category: General anaesthetic. Storage: Anaesthetic Ether should be kept in a securely closed, dry container, protected from light, at a temperature not exceeding 15 ?C, and in quantities of not more than 1 kg. Labelling: The designation on the container of anaesthetic Ether must state: "Highly flammable. Do not use near an open flame orother sources of heat that may cause ignition." The name and quantity of any antioxidant added must be stated. Additional information: Anaesthetic Ether may contain a suitable antioxidant. It must not be used for anaesthesia if it has been removed from its original container for longer than 24 hours. Ether remaining in partially used containers may deteriorate rapidly. CAUTION: Vapours of ether mixed with air, oxygen, or nitrous oxide in certain concentrations are explosive. Do not use an open flame at any time during the testing procedure. | ||
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0F5N573A2Y
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DIETHYL ETHER
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C29819
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1363043
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100036
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0F5N573A2Y
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DTXSID3021720
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DB13598
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SUB11948MIG
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SUB11949MIG
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SUB36361
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CHEMBL16264
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35702
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3283
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200-467-2
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m5131
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PRIMARY | Merck Index |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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