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Approval Year

Unknown
134361
Substance Class Protein
Created
by admin
on Thu Jul 06 17:36:13 UTC 2023
Edited
by admin
on Thu Jul 06 17:36:13 UTC 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
0C5V0MRU6P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BILE ACID RECEPTOR
Common Name English
FARNESOID X-ACTIVATED RECEPTOR
Common Name English
RXR-INTERACTING PROTEIN 14
Common Name English
RETINOID X RECEPTOR-INTERACTING PROTEIN 14
Common Name English
FXR (HUMAN)
Common Name English
FARNESOID X RECEPTOR
Common Name English
NUCLEAR RECEPTOR SUBFAMILY 1 GROUP H MEMBER 4
Systematic Name English
NR1H4
Common Name English
FXR
Common Name English
BILE ACID RECEPTOR (HUMAN)
Common Name English
Code System Code Type Description
FDA UNII
0C5V0MRU6P
Created by admin on Thu Jul 06 17:36:13 UTC 2023 , Edited by admin on Thu Jul 06 17:36:13 UTC 2023
PRIMARY
Related Record Type Details
Structure of CILOFEXOR
AGONIST -> TARGET
Structure of NIDUFEXOR
AGONIST -> TARGET
Structure of OBETICHOLIC ACID
AGONIST -> TARGET
Structure of VX-984
AGONIST -> TARGET
Structure of TERN-101
AGONIST -> TARGET
Structure of URSODIOL
AGONIST -> TARGET
When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7α-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid?binding protein, which is a candidate bile acid transporter.
AGONIST
Structure of TROPIFEXOR
AGONIST -> TARGET
Structure of TUROFEXORATE ISOPROPYL
AGONIST -> TARGET
Structure of Omesdafexor
AGONIST -> TARGET
Structure of BMS-986318
AGONIST -> TARGET
GAL-4 ASSAY
Structure of CHENODIOL
AGONIST -> TARGET
CDCA, had a half-maximal effective concentration (EC50) of 50 mMand 10 micromolar murine and human FXR, respectively (Fig. 1B). These concentrations are well within the physiologic intracellular range reported in vivo (11).
AGONIST
IC50
Structure of CHENODIOL
AGONIST -> TARGET
Structure of PX-20606
AGONIST -> TARGET
GUGGULSTERONE
INHIBITOR -> TARGET
IC50
Structure of VONAFEXOR
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
NIH
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