Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 11:59:18 GMT 2023
by
admin
on
Sat Dec 16 11:59:18 GMT 2023
|
| Protein Type | RECEPTOR |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
0C5V0MRU6P
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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0C5V0MRU6P
Created by
admin on Sat Dec 16 11:59:18 GMT 2023 , Edited by admin on Sat Dec 16 11:59:18 GMT 2023
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AGONIST -> TARGET |
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AGONIST -> TARGET | |||
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AGONIST -> TARGET |
When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7α-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid?binding protein, which is a candidate bile acid transporter.
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AGONIST -> TARGET | |||
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AGONIST -> TARGET |
Time-resolved fluorescence resonance energy (TR-FRET)
BINDING
EC50
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AGONIST -> TARGET |
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AGONIST -> TARGET |
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AGONIST -> TARGET |
GAL-4 ASSAY
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AGONIST -> TARGET |
CDCA, had a
half-maximal effective concentration (EC50) of
50 mMand 10 micromolar murine and human FXR,
respectively (Fig. 1B). These concentrations are
well within the physiologic intracellular range
reported in vivo (11).
AGONIST
IC50
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AGONIST -> TARGET | |||
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AGONIST -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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AGONIST -> TARGET |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) | CHEMICAL |
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