Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H23N7O |
| Molecular Weight | 415.4873 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[2H]C1=NC(C)=NC([2H])=C1C2=NC=NC(NC[C@@H](C)C3=C4N=CC=C(C(=O)NC)C4=CC=C3)=C2
InChI
InChIKey=PEACIOGDEQRHFA-KIYKJNLWSA-N
InChI=1S/C23H23N7O/c1-14(17-5-4-6-18-19(23(31)24-3)7-8-25-22(17)18)10-28-21-9-20(29-13-30-21)16-11-26-15(2)27-12-16/h4-9,11-14H,10H2,1-3H3,(H,24,31)(H,28,29,30)/t14-/m1/s1/i11D,12D
| Molecular Formula | C23H23N7O |
| Molecular Weight | 415.4873 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Targeting DNA-Dependent Protein Kinase for Cancer Therapy. | 2017 Jun 21 |
|
| The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts. | 2018 Jun |
|
| VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells. | 2018 May 25 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:15:46 UTC 2023
by
admin
on
Sat Dec 16 11:15:46 UTC 2023
|
| Record UNII |
0C33IBK195
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
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1476074-39-1
Created by
admin on Sat Dec 16 11:15:46 UTC 2023 , Edited by admin on Sat Dec 16 11:15:46 UTC 2023
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0C33IBK195
Created by
admin on Sat Dec 16 11:15:46 UTC 2023 , Edited by admin on Sat Dec 16 11:15:46 UTC 2023
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72188357
Created by
admin on Sat Dec 16 11:15:46 UTC 2023 , Edited by admin on Sat Dec 16 11:15:46 UTC 2023
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C129061
Created by
admin on Sat Dec 16 11:15:46 UTC 2023 , Edited by admin on Sat Dec 16 11:15:46 UTC 2023
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