LINRODOSTAT

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H24ClFN2O
Molecular Weight	410.912
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]([C@H]1CC[C@H](CC1)C2=C3C=C(F)C=CC3=NC=C2)C(=O)NC4=CC=C(Cl)C=C4

InChI

InChIKey=KRTIYQIPSAGSBP-ZACQAIPSSA-N

InChI=1S/C24H24ClFN2O/c1-15(24(29)28-20-9-6-18(25)7-10-20)16-2-4-17(5-3-16)21-12-13-27-23-11-8-19(26)14-22(21)23/h6-17H,2-5H2,1H3,(H,28,29)/t15-,16-,17+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H24ClFN2O
Molecular Weight	410.912
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Indoleamine 2,3-dioxygenase 20 Target ID: CHEMBL4685 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29473428	Inhibitor 8504		1.1 nM [IC50]

C_max

Value	Dose	Co-administered	Analyte	Population
781 ng/mL CLINICAL TRIAL https://classic.clinicaltrials.gov/ct2/show/results/NCT03792750	100 mg 1 times / day steady-state, oral dose: 100 mg route of administration: Oral experiment type: STEADY-STATE co-administered: NIVOLUMAB	NIVOLUMAB	LINRODOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
701.9 ng/mL CLINICAL TRIAL https://classic.clinicaltrials.gov/ct2/show/results/NCT03792750	100 mg 1 times / day steady-state, oral dose: 100 mg route of administration: Oral experiment type: STEADY-STATE co-administered: NIVOLUMAB	NIVOLUMAB	LINRODOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
596 ng/mL CLINICAL TRIAL https://classic.clinicaltrials.gov/ct2/show/results/NCT03792750	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: NIVOLUMAB	NIVOLUMAB	LINRODOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
5922.3 ng × h/mL CLINICAL TRIAL https://classic.clinicaltrials.gov/ct2/show/results/NCT03792750	100 mg 1 times / day steady-state, oral dose: 100 mg route of administration: Oral experiment type: STEADY-STATE co-administered: NIVOLUMAB	NIVOLUMAB	LINRODOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
6048.3 ng × h/mL CLINICAL TRIAL https://classic.clinicaltrials.gov/ct2/show/results/NCT03792750	100 mg 1 times / day steady-state, oral dose: 100 mg route of administration: Oral experiment type: STEADY-STATE co-administered: NIVOLUMAB	NIVOLUMAB	LINRODOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3380.8 ng × h/mL CLINICAL TRIAL https://classic.clinicaltrials.gov/ct2/show/results/NCT03792750	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: NIVOLUMAB	NIVOLUMAB	LINRODOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
22.9 h CLINICAL TRIAL https://classic.clinicaltrials.gov/ct2/show/results/NCT03792750	100 mg 1 times / day steady-state, oral dose: 100 mg route of administration: Oral experiment type: STEADY-STATE co-administered: NIVOLUMAB	NIVOLUMAB	LINRODOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Substance Class	Chemical Created by `admin` on `Wed Apr 02 10:12:55 GMT 2025` Edited by `admin` on `Wed Apr 02 10:12:55 GMT 2025`
Record UNII	0A7729F42K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(2R)-N-(4-CHLOROPHENYL)-2-(4-(6-FLUORO-4-QUINOLYL)CYCLOHEXYL)PROPANAMIDE, CIS-

Preferred Name

English

LINRODOSTAT

Official Name

English

LINRODOSTAT [USAN]

Common Name

English

F-001287

Code

English

BMS-986205

Code

English

CYCLOHEXANEACETAMIDE, N-(4-CHLOROPHENYL)-4-(6-FLUORO-4-QUINOLINYL)-.ALPHA.-METHYL-, CIS-(.ALPHA.R)-

Systematic Name

English

Linrodostat [WHO-DD]

Common Name

English

ONO7701

Code

English

F001287

Code

English

linrodostat [INN]

Common Name

English

ONO-7701

Code

English

Code System Code Type Description

DRUG BANK

DB14986