CLOPENTHIXOL

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6222099 | https://www.ncbi.nlm.nih.gov/pubmed/1965312

trans-Clopenthixol is a typical antipsychotic drug of the thioxanthene class. Clopenthixol is composed of a mixture of cis-clopenthixol and trans-clopenthixol. The two isomers do not differ in several pharmacological properties, for instance, anti-noradrenergic effect. However, cis-clopenthixol possesses anti-dopaminergic effects, while trans-Clopenthixol not. Cis-Clopenthixol indicated for the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behavior.

Approval Year

PubMed

Title	Date	PubMed
The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy.	1967	4383787
Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions.	1984 Jul 13	6148252
The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria.	1986 Dec	3105243
Prolonged oculogyric crisis on addition of nifedipine to neuroleptic medication regime.	1987 Jan	3651662
Zuclopenthixol and perphenazine in patients with acute psychotic states. A double-blind multicentre study.	1987 Jul	3615572
Zuclopenthixol and haloperidol/levomepromazine in the treatment of elderly patients with symptoms of aggressiveness and agitation: a double-blind, multi-centre study.	1989	2568639
Reversible lithium neurotoxicity at normal serum level may refer to intracranial pathology.	1989 May	2732745
Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia.	1991 Dec	1822319
[acute dystonias in combined abuse of cocaine and neuroleptics].	1994 Nov 26	7990989
Central D2 receptor occupancy and effects of zuclopenthixol acetate in humans.	1995 Nov	8748043
Effect of some psychotropic drugs and a barbiturate on mycoplasmas.	2000 Apr	10773494
Antipsychotic-induced extrapyramidal syndromes. Risperidone compared with low- and high-potency conventional antipsychotic drugs.	2001 Jul	11549212
Clozapine and weight gain.	2001 May	11329412
Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms.	2003 Jul	12957216
Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats.	2004 Aug	15497819
Long term results of unilateral posteroventral pallidotomy for antipsychotic drug induced tardive dyskinesia.	2005 Jul	15965227
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].	2006 Jun	16856516
Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine.	2007 Fall	18025545
Remission of schizophrenia psychosis and strong reduction of obsessive-compulsive disorder after adding clozapine to aripiprazole.	2009 Nov 13	19766686
Severe laryngeal dystonia in a patient receiving zuclopenthixol "Acuphase" and fluoxetine.	2010 Apr	20175668
Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses.	2012 Apr 18	22513898
Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.	2012 Sep	22718540
Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate.	2014 Mar	23771405
Paradoxical severe agitation induced by add-on high-doses quetiapine in schizo-affective disorder.	2014 May 15	24582773

Patents

Substance Class	Mixture Created by `admin` on `Fri Dec 15 20:38:12 GMT 2023` Edited by `admin` on `Fri Dec 15 20:38:12 GMT 2023`
Record UNII	0A432D932A
Record Status	`Validated (UNII)`
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Name

Type

Language

CLOPENTHIXOL

Official Name

English

NSC-64087

Code

English

CLOPENTHIXOL [MI]

Common Name

English

AY-62021

Code

English

SORDINOL

Brand Name

English

Clopenthixol [WHO-DD]

Common Name

English

1-PIPERAZINEETHANOL, 4-(3-(2-CHLORO-9H-THIOXANTHEN-9-YLIDENE)PROPYL)-

Common Name

English

clopenthixol [INN]

Common Name

English

4-[3-(2-Chlorothioxanthen-9-ylidene)propyl]-1-piperazineethanol

Common Name

English

CLOPENTHIXOL [USAN]

Common Name

English

N-746

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C66883