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Description

trans-Clopenthixol is a typical antipsychotic drug of the thioxanthene class. Clopenthixol is composed of a mixture of cis-clopenthixol and trans-clopenthixol. The two isomers do not differ in several pharmacological properties, for instance, anti-noradrenergic effect. However, cis-clopenthixol possesses anti-dopaminergic effects, while trans-Clopenthixol not. Cis-Clopenthixol indicated for the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behavior.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia.
1991 Dec
Central D2 receptor occupancy and effects of zuclopenthixol acetate in humans.
1995 Nov
Effect of some psychotropic drugs and a barbiturate on mycoplasmas.
2000 Apr
Long term results of unilateral posteroventral pallidotomy for antipsychotic drug induced tardive dyskinesia.
2005 Jul
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].
2006 Jun
Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine.
2007 Fall
Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses.
2012 Apr 18
Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.
2012 Sep
Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate.
2014 Mar
Patents

Patents

20030015197
10
20030073133
4
Substance Class Mixture
Created
by admin
on Fri Dec 15 20:38:12 UTC 2023
Edited
by admin
on Fri Dec 15 20:38:12 UTC 2023
Record UNII
0A432D932A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CLOPENTHIXOL
INN   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
NSC-64087
Code English
CLOPENTHIXOL [MI]
Common Name English
AY-62021
Code English
SORDINOL
Brand Name English
Clopenthixol [WHO-DD]
Common Name English
1-PIPERAZINEETHANOL, 4-(3-(2-CHLORO-9H-THIOXANTHEN-9-YLIDENE)PROPYL)-
Common Name English
clopenthixol [INN]
Common Name English
4-[3-(2-Chlorothioxanthen-9-ylidene)propyl]-1-piperazineethanol
Common Name English
CLOPENTHIXOL [USAN]
Common Name English
N-746
Code English
Classification Tree Code System Code
NCI_THESAURUS C66883
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
WHO-VATC QN05AF02
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
WHO-ATC N05AF02
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
Code System Code Type Description
EVMPD
SUB06736MIG
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
MESH
D003006
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
WIKIPEDIA
Clopenthixol
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
NSC
64087
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
CAS
982-24-1
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
MERCK INDEX
m3653
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY Merck Index
CHEBI
59115
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
ChEMBL
CHEMBL53904
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
NCI_THESAURUS
C154301
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
DRUG BANK
DB13841
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
FDA UNII
0A432D932A
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
DRUG CENTRAL
4397
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
EPA CompTox
DTXSID9048223
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
ECHA (EC/EINECS)
213-566-0
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
INN
1315
Created by admin on Fri Dec 15 20:38:12 UTC 2023 , Edited by admin on Fri Dec 15 20:38:12 UTC 2023
PRIMARY
All of the following components must be present:
Structure of ZUCLOPENTHIXOL
Structure of CLOPENTHIXOL, TRANS
Related Record Type Details
CLOPENTHIXOL
ACTIVE MOIETY
Definition References
NIH
NCATS
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