Details
Stereochemistry | ABSOLUTE |
Molecular Formula | 2C4H5NO4.Ca.2H.3H2O |
Molecular Weight | 358.313 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[H+].O.O.O.[Ca++].N[C@@H](CC([O-])=O)C([O-])=O.N[C@@H](CC([O-])=O)C([O-])=O
InChI
InChIKey=ZDGBQWHMMCENFS-UBMJGTQTSA-L
InChI=1S/2C4H7NO4.Ca.3H2O/c2*5-2(4(8)9)1-3(6)7;;;;/h2*2H,1,5H2,(H,6,7)(H,8,9);;3*1H2/q;;+2;;;/p-2/t2*2-;;;;/m00..../s1
Molecular Formula | H |
Molecular Weight | 1.0079 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Ca |
Molecular Weight | 40.078 |
Charge | 2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C4H5NO4 |
Molecular Weight | 131.0868 |
Charge | -2 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.worldcat.org/title/fundamentals-of-biochemistry-life-at-the-molecular-level/oclc/910538334Advances in Protein Chemistry (1945), v.2, p.308, retrieved from: https://books.google.ru/books?id=QRyhIaEwrngCCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/15703381 |
https://www.ncbi.nlm.nih.gov/pubmed/3814227 |
https://www.ncbi.nlm.nih.gov/pubmed/16061593
Sources: https://www.worldcat.org/title/fundamentals-of-biochemistry-life-at-the-molecular-level/oclc/910538334Advances in Protein Chemistry (1945), v.2, p.308, retrieved from: https://books.google.ru/books?id=QRyhIaEwrngC
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/15703381 |
https://www.ncbi.nlm.nih.gov/pubmed/3814227 |
https://www.ncbi.nlm.nih.gov/pubmed/16061593
Disodium aspartate is used in organic biosynthesis.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814227
Curator's Comment: Aspartic acid is produced in the brain and acts as endogenous neurotransmitter.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q7L266 Gene ID: 80150.0 Gene Symbol: ASRGL1 Target Organism: Homo sapiens (Human) |
|||
Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15703381 |
18.4 µM [EC50] | ||
Target ID: P08236 Gene ID: 2990.0 Gene Symbol: GUSB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: - |
no |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: - |
no | |||
Page: - |
yes | |||
Page: - |
yes | |||
Page: - |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/12706335/ Page: - |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/24147638/ Page: - |
yes |
PubMed
Title | Date | PubMed |
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Ketanserin for the treatment of preeclampsia. | 2001 |
|
Characterization of the protective effects of melatonin and related indoles against alpha-naphthylisothiocyanate-induced liver injury in rats. | 2001 |
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Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. | 2001 Feb |
|
Aging-induced changes in 24-h rhythms of mitogenic responses, lymphocyte subset populations and neurotransmitter and amino acid content in rat submaxillary lymph nodes during Freund's adjuvant arthritis. | 2001 Feb |
|
Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver. | 2001 Feb |
|
Comparison of clinical, virologic and pathologic features in patients with acute hepatitis B and C. | 2001 Feb |
|
Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes. | 2001 Feb |
|
Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus. | 2001 Feb |
|
Endotoxin clearance and its relation to hepatic and renal disturbances in rats with liver cirrhosis. | 2001 Feb |
|
Severe veno-occlusive disease after allogeneic bone marrow or peripheral stem cell transplantation--role of transjugular intrahepatic portosystemic shunt (TIPS). | 2001 Feb |
|
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection. | 2001 Feb |
|
Serum hepatic biochemical activity in two populations of workers exposed to styrene. | 2001 Feb |
|
A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer. | 2001 Feb 1 |
|
DNA-protein crosslinks induced by nickel compounds in isolated rat lymphocytes: role of reactive oxygen species and specific amino acids. | 2001 Feb 1 |
|
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat. | 2001 Feb 1 |
|
Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin. | 2001 Feb 12 |
|
Sodium nitroprusside-induced seizures and adenosine release in rat hippocampus. | 2001 Feb 16 |
|
Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease. | 2001 Feb 16 |
|
Evidence for microvesicular storage and release of glycine in rodent pinealocytes. | 2001 Feb 16 |
|
A novel osteopontin-like protein is expressed in the trout ovary during ovulation. | 2001 Feb 2 |
|
Covariate effects on the apparent clearance of tacrolimus in paediatric liver transplant patients undergoing conversion therapy. | 2001 Jan |
|
Coagulation profile, hepatic function, and hemodynamics following Fontan-type operations. | 2001 Jan |
|
Comparison of the efficacy and tolerability of fluvastatin extended-release and immediate-release formulations in the treatment of primary hypercholesterolemia: a randomized trial. | 2001 Jan |
|
Characterization of peptide substrates and viral enzyme that affect the cleavage site specificity of the human spumaretrovirus proteinase. | 2001 Jan |
|
Structure activity relationship of antiproliferative N-acyl-aspartic acid dimethyl ester. 2. Variation of the aspartyl moiety. | 2001 Jan |
|
Plasma ascorbate concentrations are not correlated with milk somatic cell count and metabolic profile in lactating and dry cows. | 2001 Jan |
|
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). IV. Toxicologic and pathophysiologic observations in lactating goats and their suckling kids fed on the irritant herbs Euphorbia nubica and Euphorbia helioscopia: an etiologic model for investigations on the putative risk of cancer by consumption of food p. | 2001 Jan |
|
Exercise improved accumulation of visceral fat and simultaneously impaired endothelium-dependent relaxation in old rats. | 2001 Jan |
|
Portal-Systemic shunts reduce asialoglycoprotein receptor density in rats. | 2001 Jan |
|
Chloroplast genetic engineering. | 2001 Jan |
|
The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model. | 2001 Jan |
|
Oxygen free radical generation in healthy blood donors and cardiac patients: the protective effect of allopurinol. | 2001 Jan |
|
Leukocyte filtration in the early reperfusion phase on cardiopulmonary bypass reduces myocardial injury. | 2001 Jan |
|
Elevation of hepatic transaminases after enoxaparin use: case report and review of unfractionated and low-molecular-weight heparin-induced hepatotoxicity. | 2001 Jan |
|
The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates. | 2001 Jan |
|
Ehlers-Danlos syndrome type IV with a unique point mutation in COL3A1 and familial phenotype of myocardial infarction without organic coronary stenosis. | 2001 Jan |
|
Effects of aflatoxin and carotenoids on growth performance and immune response in mule ducklings. | 2001 Jan |
|
Propylene glycol toxicosis in a llama. | 2001 Jan 15 |
|
The effect of ketamine hydrochloride anesthesia on basal and N-methyl-D,L-aspartate induced plasma prolactin secretion in the adult male rhesus monkey. | 2001 Jan 19 |
|
Three-dimensional structure of Erwinia chrysanthemi pectin methylesterase reveals a novel esterase active site. | 2001 Jan 26 |
|
Characterization, amino acid sequence and evolution of edema-inducing, basic phospholipase A2 from Trimeresurus flavoviridis venom. | 2001 Jul |
|
Serum hyaluronic acid as an early prognostic marker in biliary atresia. | 2001 Mar |
|
Metabolic changes after cardiac surgery. | 2001 Mar |
|
Stress responses and changes in protein metabolism in carp Cyprinus carpio during cadmium exposure. | 2001 Mar |
|
Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population. | 2001 Mar |
|
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. | 2001 Mar 1 |
|
In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. | 2001 Mar 1 |
|
Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase. | 2001 Mar 1 |
|
Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects. | 2001 Mar 1 |
|
Pathobiochemical mechanisms involved in the control of the disease caused by Trypanosoma congolense in African grey duiker (Sylvicapra grimmia). | 2001 Mar 5 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814227
Aspartic acid is a nutrient component found in animal and vegetable sources. In clinical trials to alleviate opioid abstinence it was administered orally.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15703381
Activation of recombinant NMDA receptors was measured using two-electrode voltage clamp. Current and voltage electrodes were made from thin-walled borosilicate glass using a PP-830 electrode puller and when filled with 3 M KCl, possessed resistances of between 0.5 and 1.5 MΩ. Oocytes were voltage-clamped at potentials of -40 mV. Aspartate was able to activate wild type NR1/NR2A NMDA receptors with EC50 of 18.4 uM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 06:43:29 GMT 2023
by
admin
on
Sat Dec 16 06:43:29 GMT 2023
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Record UNII |
09U1335X8K
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Record Status |
Validated (UNII)
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Record Version |
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-
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SUB33471
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100000127448
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244-185-8
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21059-46-1
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23724805
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DTXSID70209068
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603067-18-1
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09U1335X8K
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ANHYDROUS->SOLVATE |
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ACTIVE MOIETY |