PROPIZEPINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20N4O
Molecular Weight	296.3669
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CN1C2=C(NC3=C(C=CC=N3)C1=O)C=CC=C2)N(C)C

InChI

InChIKey=YFLBETLXDPBWTD-UHFFFAOYSA-N

InChI=1S/C17H20N4O/c1-12(20(2)3)11-21-15-9-5-4-8-14(15)19-16-13(17(21)22)7-6-10-18-16/h4-10,12H,11H2,1-3H3,(H,18,19)

HIDE SMILES / InChI

Molecular Formula	C17H20N4O
Molecular Weight	296.3669
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20487994 | https://www.ncbi.nlm.nih.gov/pubmed/996559

Propizepine is a benzodiazepinone derivative patented by Laboratoires U.P.S.A. as antidepressive, antihistaminic, antianaphylactic, thymoanaleptic, antiserotonine, antispasmodic, and analgetic compound. Propizepine used in France for the treatment of depression in the 1970s.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of long-term treatment of rats with antidepressants on adrenergic-receptor sensitivity in cerebral cortex: Structure activity study.	1983	20487994
Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia.	2001 Jul	11408566
Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures.	2006 Jan	16457632
Method development for a pyridobenzodiazepine library with multiple diversification points.	2008 Mar-Apr	18260649

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:37:11 GMT 2023` Edited by `admin` on `Fri Dec 15 15:37:11 GMT 2023`
Record UNII	09B57945V9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROPIZEPINE

Official Name

English

6,11-DIHYDRO-6-(2-(DIMETHYLAMINO)-2-METHYLETHYL)-5H-PYRIDO(2,3-B)(1,5)BENZODIAZEPIN-5-ONE

Systematic Name

English

PROPIEZEPINE, (±)-

Common Name

English

(±)-PROPIEZEPINE

Common Name

English

UP 106

Code

English

5H-PYRIDO(2,3-B)(1,5)BENZODIAZEPIN-5-ONE, 6-(2-(DIMETHYLAMINO)PROPYL)-6,11-DIHYDRO-

Systematic Name

English

VAGRAN 50

Brand Name

English

propizepine [INN]

Common Name

English

PROPIZEPINE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265