Details
Stereochemistry | RACEMIC |
Molecular Formula | C14H20N2O |
Molecular Weight | 232.3214 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(N1CCCC1)C(=O)NC2=C(C)C=CC=C2
InChI
InChIKey=WJOQWLQQCYYQBE-UHFFFAOYSA-N
InChI=1S/C14H20N2O/c1-11-7-3-4-8-13(11)15-14(17)12(2)16-9-5-6-10-16/h3-4,7-8,12H,5-6,9-10H2,1-2H3,(H,15,17)
Molecular Formula | C14H20N2O |
Molecular Weight | 232.3214 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/776194
Sources: https://www.ncbi.nlm.nih.gov/pubmed/776194
Aptocaine (Pirothesin, Pharmaceutical Manufacturing Company) is a new local anaesthetic agent, the first of note to be synthesized in Britain. It is related toprilocaine; like prilocaine, it has a low sub-cutaneous toxicity, but preliminary studies suggest that, unlike prilocaine, it does not induce methaemoglobinaemia. It has been found to produce satisfactory analgesia, of longer duration than lignocaine, by several routes, at a concentration of 3% in animals.
Approval Year
PubMed
Title | Date | PubMed |
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[A new local anesthetic for dentistry: 1st study of aptocaine chlorhydrate in combination with corbadrine chlorhydrate]. | 1971 Jun-Jul |
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Intradermal study of a new local anaesthetic agent aptocaine. | 1976 Apr |
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Identification of metabolites of aptocaine and some related compounds [proceedings]. | 1976 Dec |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/776194
In a double-blind trial in 28 human volunteers, a new local anaesthetic agent, aptocaine, was compared intradermally at 1, 2 and 3% concentrations with lignocaine 2% and bupivacaine 0.5%.
Route of Administration:
Topical
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:29:05 GMT 2023
by
admin
on
Fri Dec 15 15:29:05 GMT 2023
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Record UNII |
08K838NNTE
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C245
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08K838NNTE
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100000087165
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71695
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19281-29-9
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242-932-2
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DTXSID40864880
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C72172
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SUB05549MIG
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C012187
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CHEMBL2104078
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Related Record | Type | Details | ||
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |