Details
Stereochemistry | ACHIRAL |
Molecular Formula | C8H11NO |
Molecular Weight | 137.179 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COCCC1=CC=CC=N1
InChI
InChIKey=QRBVCAWHUSTDOT-UHFFFAOYSA-N
InChI=1S/C8H11NO/c1-10-7-5-8-4-2-3-6-9-8/h2-4,6H,5,7H2,1H3
Molecular Formula | C8H11NO |
Molecular Weight | 137.179 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Metyridine has been shown to possess anthelmintic activity, particularly for the nematodes of the alimentary canal. Methyridine is able to pass freely through most of the barriers, which maintain body integrity. It produces neuromuscular block of the decamethonium type. There appears to be sufficient difference between the sensitivity of nematode and vertebrate nervous systems to this drug to allow a wide safety margin for its use in animals. Signs of toxicity, principally dullness and lassitude, may be produced by overdosage of the drug. When given subcutaneously methyridine may cause local pain, and swelling.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4382324
Curator's Comment: Known to be CNS penetrant in sheep and calves. Human data not available
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0007274 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17649364 |
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Target ID: P32753 Gene ID: NA Gene Symbol: BCHE Target Organism: Ovis aries (Sheep) Sources: https://www.ncbi.nlm.nih.gov/pubmed/4391742 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | Promintic Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans. | 2000 |
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Methyridine (2-[2-methoxyethyl]-pyridine]) and levamisole activate different ACh receptor subtypes in nematode parasites: a new lead for levamisole-resistance. | 2003 Nov |
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Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. | 2004 Aug |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4391742
Methyridine 10(-3) M produced partial neuromuscular block in rat isolated phrenic nerve-diaphragm, which was not affected by a tetanus or by potassium or eserine.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:19:26 GMT 2023
by
admin
on
Sat Dec 16 17:19:26 GMT 2023
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Record UNII |
08760H16R0
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C250
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C66141
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100000081157
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66991
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2104
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114-91-0
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DTXSID5057624
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CHEMBL2105211
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08760H16R0
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m7509
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SUB08926MIG
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204-060-0
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34071
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |