XIBENOLOL

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H25NO2
Molecular Weight	251.3645
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC1=C(C)C(OCC(O)CNC(C)(C)C)=CC=C1

InChI

InChIKey=RKUQLAPSGZJLGP-UHFFFAOYSA-N

InChI=1S/C15H25NO2/c1-11-7-6-8-14(12(11)2)18-10-13(17)9-16-15(3,4)5/h6-8,13,16-17H,9-10H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C15H25NO2
Molecular Weight	251.3645
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Xibenolol or D-32 (dl-tert-butylamino-3-(2', 3'-dimethylphenoxy)-2-propanol hydrochloride) is a beta-blocking agent. It has been developing as a hypontesive medicine by Kowa Pharmaceutical and Teikoku Hormone, however development has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 89	Antagonist 2,849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575	Primary		Preclinical	Unknown

PubMed

Show entries

Title	Date	PubMed
Analysis of beta-adrenoceptors mediating renin release produced by isoproterenol in conscious dogs.	1980 May	6103674
Stereoselectivity in the metabolism of the beta-adrenergic blocking agent, (+/-)-1-tert-butylamino-3-(2,3-dimethylphenoxy)-2-propanol hydrochloride (xibenolol hydrochloride, D-32), in man.	1985 Feb	2861914