Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H21NO5.ClH |
| Molecular Weight | 367.824 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCN(CC)CCOC1=C2OC(C)=CC(=O)C2=C(O)C3=C1OC=C3
InChI
InChIKey=ZECDVNFXFXCUPR-UHFFFAOYSA-N
InChI=1S/C18H21NO5.ClH/c1-4-19(5-2)7-9-23-18-16-12(6-8-22-16)15(21)14-13(20)10-11(3)24-17(14)18;/h6,8,10,21H,4-5,7,9H2,1-3H3;1H
| Molecular Formula | C18H21NO5 |
| Molecular Weight | 331.363 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Amikhellin (AK), an antimitotic drug, is a synthetic water-soluble derivative of khellin, an alkaloid extracted from seeds of Ammi Visnaga. Amikhellin has been used so far mostly as a vasodiator. Amikhellin binds to double-stranded DNA by an intercalation process. It inhibits the DNA-polymerase from murine sarcoma leukemia virus.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Chromosomal and internuclear bridges induced with amikhellin in the blastomeres of newt eggs]. | 1974-12 |
|
| Studies on amikhellin. I. Intercalative binding to double-stranded DNA. | 1973 |
|
| [Action of amikhellin on chromatin and chromosomes in amphibian eggs during cleavage]. | 1972-07-01 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:47:19 GMT 2025
by
admin
on
Mon Mar 31 21:47:19 GMT 2025
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| Record UNII |
0792NR00PL
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID80961105
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