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Details

Stereochemistry ABSOLUTE
Molecular Formula C23H32O2
Molecular Weight 340.499
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEDROGESTONE

SMILES

[H][C@@]12CC[C@](C)(C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C=C(C)C4=CC(=O)CC[C@]34C

InChI

InChIKey=HCFSGRMEEXUOSS-JXEXPEPMSA-N
InChI=1S/C23H32O2/c1-14-12-17-18(21(3)9-6-16(25)13-20(14)21)7-11-23(5)19(17)8-10-22(23,4)15(2)24/h12-13,17-19H,6-11H2,1-5H3/t17-,18+,19+,21-,22-,23+/m1/s1

HIDE SMILES / InChI

Molecular Formula C23H32O2
Molecular Weight 340.499
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Medrogestone is a progesterone derivative used for the treatment of progesterone deficiency, especially those observed in the premenopausal period, haemorrhages and menorrhagia of fibroids, endometriosis, menstrual cycle disorders, etc. The drug acts by binding and activating progesterone receptors. In Europe, medrogestone is available under the name Colprone, however it is no longer marketed in the USA, Germany and Austria.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
COLPRONE
Primary
COLPRONE
Palliative
COLPRONE
Primary
COLPRONE
Primary
COLPRONE

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Take two tablets (10 mg) per day.
Route of Administration: Oral
In Vitro Use Guide
T-47D cells were incubated with medrogestone for 24h and the drug inhibited 17beta-hydroxysteroid dehydrogenase activity in a dose-dependent manner by 39% and 80% at 5 x 10(-8) M and 5 x 10(-5) M.
Substance Class Chemical
Record UNII
077DN93G5B
Record Status Validated (UNII)
Record Version