Details
Stereochemistry | ACHIRAL |
Molecular Formula | C5H12NO5P |
Molecular Weight | 197.1262 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)N(O)CCCP(O)(O)=O
InChI
InChIKey=PKMNDDZSIHLLLI-UHFFFAOYSA-N
InChI=1S/C5H12NO5P/c1-5(7)6(8)3-2-4-12(9,10)11/h8H,2-4H2,1H3,(H2,9,10,11)
Molecular Formula | C5H12NO5P |
Molecular Weight | 197.1262 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4091 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16439126 |
30.0 nM [IC50] | ||
Target ID: CHEMBL5630 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21561155 |
130.0 nM [IC50] | ||
Target ID: CHEMBL2010623 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22405649 |
320.0 nM [IC50] |
PubMed
Title | Date | PubMed |
---|---|---|
Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098. | 2006 Aug 1 |
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Molecular epidemiology of malaria in Cameroon. XXV. In vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of Plasmodium falciparum and sequence analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase. | 2007 Aug |
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Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin. | 2010 Oct 4 |
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Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase. | 2013 Apr 1 |
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DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. | 2013 Aug 8 |
|
The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs. | 2014 Jan 15 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:58:41 GMT 2023
by
admin
on
Sat Dec 16 10:58:41 GMT 2023
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Record UNII |
0711Y106HV
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Record Status |
Validated (UNII)
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Record Version |
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0711Y106HV
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66508-32-5
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DTXSID50216710
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Related Record | Type | Details | ||
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ACTIVE MOIETY |