SORBITAN MONOOLEATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H44O6
Molecular Weight	428.6026
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(OC[C@H](O)[C@H]1O)[C@H](O)COC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

InChIKey=NWGKJDSIEKMTRX-AAZCQSIUSA-N

InChI=1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H44O6
Molecular Weight	428.6026
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=173.75 | https://www.drugs.com/inactive/sorbitan-monooleate-461.html | https://www.spectrumchemical.com/OA_HTML/chemical-products_Sorbitan-Monooleate_SPA80.jsp?minisite=10020&respid=22372&phrase=Sorbitan%20Monooleate | https://www.ncbi.nlm.nih.gov/pubmed/25261708 | https://www.ncbi.nlm.nih.gov/pubmed/22197498

Sorbitan monooleate (Span 80) is a partial oleate ester of sorbitol and its mono- and dianhydrides. Sorbitan Monooleate is a nonionic emulsifier and surfactant and used in cosmetics and foods. It is a food additive with the E number E495. Span 80 was suitable as surfactant in the preparation of Poly(divinylbenzene) emulsion-derived (PolyHIPE) solid foam. Anionic nanoparticles based on Span 80 as low-cost, simple and efficient non-viral gene-transfection systems. Sorbitan monooleate is approved by FDA to be used as an emulsifier in polymer dispersions that are used in the clarification of cane or beet sugar juice or liquor in an amount not to exceed 7.5 percent by weight in the final polymer dispersion. The additive is used in an amount not to exceed 0.70 part per million in sugar juice and 1.4 parts per million in sugar liquor.

Approval Year

PubMed

Title	Date	PubMed
Rheological properties of creams with four different surfactant combinations - effect of storage time and conditions.	2001 Jun 19	11397580
Co-surfactant of ethoxylated sorbitan ester and sorbitan monooleate for enhanced flushing of tetrachloroethylene.	2002 Oct	12365839
Rheological properties of three component creams containing sorbitan monoesters as surfactants.	2002 Oct 24	12429489
Investigation on the release of fluorescent markers from w/o/w emulsions by fluorescence-activated cell sorter.	2004 May 18	15120896
The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion II: stable gastrointestinal absorption of a poorly water soluble new compound, ER-1258 in bile-fistula rats.	2005 Aug	16141605
Gene transfection into HeLa cells by vesicles containing cationic peptide lipid.	2005 Aug	16116271
Preparation of a highly stable niosome and its hydrotrope-solubilization action to drugs.	2005 Nov 22	16285768
Single dose and multiple dose studies of itraconazole nanoparticles.	2006 Jun	16516450
Process and formulation variables in the preparation of injectable and biodegradable magnetic microspheres.	2007 Apr 4	17407608
Formulation and evaluation of flurbiprofen microemulsion.	2008 Jan	18220549
Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process.	2008 Mar	17964129
Extraction of Co(II) from aqueous solution using emulsion liquid membrane.	2008 Mar 1	17658686
Fast dissolving films made of maltodextrins.	2008 Nov	18667164
Sorbitan sesquioleate, a common emulsifier in topical corticosteroids, is an important contact allergen.	2008 Nov-Dec	19134436
The influence of non-ionic surfactants on the rheological properties of drug/microcrystalline cellulose/water mixtures and their use in the preparation and drug release performance of pellets prepared by extrusion/spheronization.	2009 Jun 28	19491024
Structure of high internal phase aqueous-in-oil emulsions and related inverse micelle solutions. 3. Variation of surfactant.	2009 Sep 10	19681586
Structure of high internal phase aqueous-in-oil emulsions and related inverse micelle solutions. 4. Surfactant mixtures.	2009 Sep 10	19681585
Preparation and evaluation of fast-release mephenamic acid microspheres.	2010	20681746
Vaccine development in Staphylococcus aureus: taking the biofilm phenotype into consideration.	2010 Aug	20602638
Evaluation of lung tolerance of ethanol, propylene glycol, and sorbitan monooleate as solvents in medical aerosols.	2010 Feb	20131984
Study on ultrasonically assisted emulsification and recovery of copper(II) from wastewater using an emulsion liquid membrane process.	2010 Feb	19800281
A metal-chelate affinity reverse micellar system for protein extraction.	2010 Jan-Feb	19830821
Removal of 241Am from aqueous nitrate solutions by liquid surfactant membrane containing 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester as ion carrier.	2010 Jun	20488505
Evaluation of a new oil adjuvant for use in peptide-based cancer vaccination.	2010 Oct	20678155
Development and evaluation of emulsions from Carapa guianensis (Andiroba) oil.	2010 Sep	20824515

Sample Use Guides

In Vitro Use Guide

Under the optimal conditions in the fed-batch culture with 5 g/l Sorbitan monooleate (Span 80), the cell mass and the concentration, content, and productivity of retinal were 24.7 g/l, 600 mg/l, 24.3mg/g-cells, and 18 mg l(-1)h(-1) after 33 h, respectively.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:58:15 UTC 2023` Edited by `admin` on `Sat Dec 16 16:58:15 UTC 2023`
Record UNII	06XEA2VD56
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SORBITAN MONOOLEATE

Official Name

English

sorbitan oleate [INN]

Common Name

English

INS NO.494

Code

English

SORBITAN, MONO-9-OCTADECENOATE

Common Name

English

SORBITAN MONO-OLETAE

Common Name

English

SORBITAN MONOOLEATE [FCC]

Common Name

English

SORBITAN MONOOLEATE [VANDF]

Common Name

English

ARLACEL 80

Brand Name

English

SORBITAN, MONO-(9Z)-9-OCTADECENOATE

Common Name

English

NSC-406239

Code

English

SORBITAN OLEATE

Official Name

English

SPAN 80

Brand Name

English

SORBITAN MONOOLEATE [II]

Common Name

English

SORBITAN MONOOLEATE [USAN]

Common Name

English

D-GLUCITOL, 1,4-ANHYDRO-, 6-(9-OCTADECENOATE)

Common Name

English

SORBITAN ESTERS SORBITAN OLEATE [MI]

Common Name

English

SORBITAN OLEATE [EP MONOGRAPH]

Common Name

English

INS-494

Code

English

ANHYDROSORBITOL MONOOLEATE

Common Name

English

E-494

Code

English

SORBITAN OLEATE [MART.]

Common Name

English

Sorbitan mono-oleate [WHO-DD]

Common Name

English

1,4-ANHYDRO-D-GLUCITOL, 6-(9-OCTADECENOATE

Common Name

English

SORBITAN OLEATE [INCI]

Common Name

English

SORBITAN MONOOLEATE [HSDB]

Common Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-494

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

CFR

21 CFR 173.75

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

JECFA EVALUATION

INS-494

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

NCI_THESAURUS

C83486

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

Code System Code Type Description

NSC

406239

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

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EVMPD

SUB23477

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SMS_ID

100000088792

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RXCUI

1363056

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RxNorm

ECHA (EC/EINECS)

215-665-4

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

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MERCK INDEX

m10120

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

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Merck Index

CAS

1338-43-8

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

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MESH

C018665

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ChEMBL

CHEMBL2107274

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INN

1875

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FDA UNII

06XEA2VD56

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EPA CompTox

DTXSID6027397

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

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WIKIPEDIA

Sorbitan monooleate

Created by admin on Sat Dec 16 16:58:16 UTC 2023 , Edited by admin on Sat Dec 16 16:58:16 UTC 2023

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EVMPD

SUB10598MIG

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

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HSDB

5822

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PUBCHEM

9920342

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DAILYMED

06XEA2VD56

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

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NCI_THESAURUS

C75654

Created by admin on Sat Dec 16 16:58:15 UTC 2023 , Edited by admin on Sat Dec 16 16:58:15 UTC 2023

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Related Record Type Details


					06XEA2VD56

SORBITAN MONOOLEATE

ACTIVE MOIETY