LIOTHYRONINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H12I3NO4
Molecular Weight	650.9735
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H](CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)C(O)=O

InChI

InChIKey=AUYYCJSJGJYCDS-LBPRGKRZSA-N

InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C15H12I3NO4
Molecular Weight	650.9735
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6617571http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/10379s47lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/mesh/68014284

Liothyronine (CYTOMEL®) is a T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than its prohormone thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. The mechanisms by which thyroid hormones exert their physiologic action are not well understood. These hormones enhance oxygen consumption by most tissues of the body, increase the basal metabolic rate and the metabolism of carbohydrates, lipids, and proteins. Thus, they exert a profound influence on every organ system in the body and are of particular importance in the development of the central nervous system. Thyroid hormone drugs are indicated: as the replacement or supplemental therapy in patients with hypothyroidism of any etiology; as pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters; as diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Thyroid hormone receptor alpha 14 Target ID: CHEMBL1860 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/10379s47lbl.pdf	Agonist 2662	0.1 nM [Kd]
Thyroid hormone receptor beta-1 25 Target ID: CHEMBL1947 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/10379s47lbl.pdf	Agonist 2662	0.1 nM [Kd]
Thyroid hormone receptor alpha 14 Target ID: CHEMBL1860 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12109914	Agonist 2662	0.1 nM [Kd]
Thyroid hormone receptor beta-1 25 Target ID: CHEMBL1947 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12109914	Agonist 2662	0.1 nM [Kd]

Conditions

Condition	Modality	Highest Phase	Product
Hypothyroidism 10 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/10379s47lbl.pdf	Primary	Approved 8360	CYTOMEL Approved Use Thyroid hormone drugs are indicated: 1. As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema and ordinary hypothyroidism in patients of any age (pediatric patients, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism. 2. As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto’s) and multinodular goiter. 3. As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy. Launch Date -4.3079041E11
Euthyroid goiters 9 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/10379s47lbl.pdf	Primary	Approved 8360	CYTOMEL Approved Use Thyroid hormone drugs are indicated: 1. As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema and ordinary hypothyroidism in patients of any age (pediatric patients, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism. 2. As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto’s) and multinodular goiter. 3. As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy. Launch Date -4.3079041E11
Mild hyperthyroidism 5 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/10379s47lbl.pdf	Diagnostic	Approved 8360	CYTOMEL Approved Use Thyroid hormone drugs are indicated: 1. As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema and ordinary hypothyroidism in patients of any age (pediatric patients, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism. 2. As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto’s) and multinodular goiter. 3. As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy. Launch Date -4.3079041E11
Hyperlipidemia 80 Sources: https://worldwide.espacenet.com/publicationDetails/claims?CC=US&NR=3917832A&KC=A&FT=D&ND=&date=19751104&DB=&locale=	Primary	Basic research	Unknown Approved Use Unknown

C_max

Value	Dose	Analyte	Population
346 ng/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:	LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
342 ng/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:	LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
404 ng/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:	LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED

AUC

Value	Dose	Analyte	Population
4370 ng × h/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:	LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
4740 ng × h/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:	LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
4926 ng × h/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:	LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
12929 ng × h/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:	LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
13938 ng × h/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:	LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
22.04 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24977379	50 μg 1 times / day multiple, oral dose: 50 μg route of administration: Oral experiment type: MULTIPLE co-administered:		LIOTHYRONINE SODIUM plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Doses

Dose	Population	Adverse events
10794.4 ug 2 times / day multiple, oral Overdose Dose: 10794.4 ug, 2 times / day Route: oral Route: multiple Dose: 10794.4 ug, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/32158485 Page: p.2	unhealthy, 20 n = 1 Health Status: unhealthy Condition: Fatigue Age Group: 20 Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/32158485 Page: p.2	Disc. AE: Anxiety, Palpitations... AEs leading to discontinuation/dose reduction: Anxiety (severe) Palpitations Agitation Shortness of breath Irritability Tachycardia Tremor Sources: https://pubmed.ncbi.nlm.nih.gov/32158485 Page: p.2
15000 ug 2 times / day multiple, oral Overdose Dose: 15000 ug, 2 times / day Route: oral Route: multiple Dose: 15000 ug, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/32158485 Page: p.2	unhealthy, 30 n = 1 Health Status: unhealthy Condition: Hypothyroidism Age Group: 30 Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/32158485 Page: p.2	Disc. AE: Nausea, Vomiting... AEs leading to discontinuation/dose reduction: Nausea Vomiting Abdominal pain Headache (severe) Confusion Disorientation Diplopia Sources: https://pubmed.ncbi.nlm.nih.gov/32158485 Page: p.2
50 ug 2 times / day multiple, oral Highest studied dose Dose: 50 ug, 2 times / day Route: oral Route: multiple Dose: 50 ug, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/32120028 Page: p.3	unhealthy, 39 ± 6.2 n = 2 Health Status: unhealthy Condition: Multiple sclerosis Age Group: 39 ± 6.2 Sex: M+F Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/32120028 Page: p.3	DLT: Anxiety, Tachycardia... Dose limiting toxicities: Anxiety (50%) Tachycardia (50%) Loose stools (100%) Sources: https://pubmed.ncbi.nlm.nih.gov/32120028 Page: p.3
37.5 ug 2 times / day multiple, oral MTD Dose: 37.5 ug, 2 times / day Route: oral Route: multiple Dose: 37.5 ug, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/32120028 Page: p.3	unhealthy, 39 ± 6.2 n = 4 Health Status: unhealthy Condition: Multiple sclerosis Age Group: 39 ± 6.2 Sex: M+F Population Size: 4 Sources: https://pubmed.ncbi.nlm.nih.gov/32120028 Page: p.3	Sources: https://pubmed.ncbi.nlm.nih.gov/32120028 Page: p.3

AEs

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-010973	http://www.3bsc.com/index/pro_info.php?id=33471
AA Blocks	AA0032E1	http://www.aablocks.com/goods/Goods/detail?id=AA0032E1
AEchem Scientific Corp., USA	AE044693	http://www.aechemsc.com/info_products/AE044693.php
AHH Chemical co.,ltd	MT-36644	http://www.ahhchemical.com/product/MT-36644.html
Aaron Chemicals	AR00335T	http://www.aaronchem.com/6893-02-3
AbMole Bioscience	M6079	http://www.abmole.com/products/triiodothyronine.html
Acros Organics	AC437260010	https://www.fishersci.com/shop/products/3-3-5-triiodo-l-thyronine-95-acros-organics/AC437260010
Alfa Aesar	H34068	https://www.alfa.com/en/catalog/H34068/
Alfa Chemistry	AP6893023-A	https://reagents.alfa-chemistry.com/product/3-3-5-triiodo-l-thyronine-t3-solution-cas-6893-02-3-15165.html
Alfa Chemistry	AP6893023-B	https://reagents.alfa-chemistry.com/product/liothyronine-cas-6893-02-3-15166.html
Alfa Chemistry	AP6893023-C	https://reagents.alfa-chemistry.com/product/liothyronine-cas-6893-02-3-15167.html
Alfa Chemistry	3130-96-9	https://www.alfa-chemistry.com/cas_3130-96-9.htm
Alsachim	3491	http://www.alsachim.com/product-C4781-glo.bal-view.html
Angene	AGN-PC-0WA1WH	http://www.angenechemical.com/productshow/AGN-PC-0WA1WH.html
Anward	ANW-60592	http://www.anward.com/pro_result/47043
Aurora Fine Chemicals LLC	A13.107.894	http://online.aurorafinechemicals.com/info?ID=A13.107.894
AvaChem Scientific	3931	http://www.avachem.com/productSearch.asp?3931
BLD Pharm	BD21401	http://www.bldpharm.com/products/6893-02-3.html
CSNpharm	CSN12771	https://www.csnpharm.com/products/triiodothyronine.html
Capot Chemical	20012	http://www.capotchem.com/en/20012.htm
Capot Chemical	PubChem20012	http://www.capotchem.com/en/20012.htm
Chem Scene	CS-4141	http://www.chemscene.com/6893-02-3.html
Chemspace	CSSB00000695812	https://chem-space.com/CSSB00000695812
Clearsynth	CS-O-31028	https://www.clearsynth.com/en/CSO31028.html
Debye Scientific	DB-021796	http://www.debyesci.com/DB-021796.html
Enamine	Z2216208625	https://www.enaminestore.com/catalog/Z2216208625
Glentham Life Sciences	GE2741	http://www.glentham.com/products/product/GE2741/
Hairui	HR132034	http://www.hairuichem.com/en/product/6893-02-3.html
Lab Network	LN00193201	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00193201
Matrix Scientific	94322	https://www.matrixscientific.com/094322.html
MedChem Express	HY-A0070A	https://www.medchemexpress.com/3,3_acute_,5-Triiodo-L-thyronine.html
MuseChem	R022695	https://www.musechem.com/product/R022695.html
OChem	6307	http://www.ocheminc.com/index.php?act=psearch&pid=893T023
Oakwood	102562	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=172240&ExtHyperLink=1
Sigma-Aldrich	564605_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/564605?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	T-074_CERILLIAN	https://www.sigmaaldrich.com/catalog/product/cerillian/t074?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	IRMM469_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/irmm469?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	PHR1504_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/phr1504?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1368008_USP	https://www.sigmaaldrich.com/catalog/product/usp/1368008?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S525744	http://www.smolecule.com/products/s525744
Smolecule	S533244	http://www.smolecule.com/products/s533244
TCI (Tokyo Chemical Industry)	T0453	http://www.tcichemicals.com/eshop/en/us/commodity/T0453/index.html
THE BioTek	bt-267087	https://www.thebiotek.com/product/inhibitors/bt-267087
THE BioTek	bt-273145	https://www.thebiotek.com/product/inhibitors/bt-273145
Tocris	6666	https://www.tocris.com/products/t3_6666
VladaChem	VL261199-100MG	https://www.vladachem.com/product.php?products=6893-02-3
abcr GmbH	AB143218	http://www.abcr.com/shop/en/AB143218
abcr GmbH	AB426281	http://www.abcr.com/shop/en/AB426281
eNovation Chemicals	D489394	http://www.enovationchem.com/productDetails.asp?productID=D489394
eNovation Chemicals	D618757	https://www.enovationchem.com/ProductDetails.asp?ProductID=D618757

PubMed

Title	Date	PubMed
Thyroid hormone regulation of apoptosis induced by retinoic acid in promyeloleukemic HL-60 cells: studies with retinoic acid receptor-specific and retinoid x receptor-specific ligands.	2000 Dec	11201846
Spatio-temporal expression of TSH beta and FSH beta genes in normally metamorphosing, metamorphosed, and metamorphosis-arrested Hynobius retardatus.	2000 Sep	11017775
Neurofilament expression in cultured rat adenohypophysial cells.	2001	11275680
Hypothalamus-hypophysis-thyroid axis, triiodothyronine and antithyroid antibodies in patients with primary and secondary Sjögren's syndrome.	2001	11254240
Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression.	2001	11077070
Effect of transient early hyperthyroidism on onset of puberty in Suffolk ram lambs.	2001 Apr	11277884
Thyroid hormone increases pacemaker activity in rat neonatal atrial myocytes.	2001 Apr	11273733
Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary.	2001 Apr	11250650
Habituation of thermal sensations, skin temperatures, and norepinephrine in men exposed to cold air.	2001 Apr	11247916
Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus).	2001 Apr 15	11241400
Nuclear cytoplasmic shuttling by thyroid hormone receptors. multiple protein interactions are required for nuclear retention.	2001 Apr 6	11152480
Changes in serum thyroid hormone levels in newborn calves as a diagnostic index of endemic goiter.	2001 Feb	11258455
Prenatal diagnosis and early in utero management of fetal dyshormonogenetic goiter.	2001 Feb	11165746
Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone.	2001 Feb 1	11171071
Identification of two novel splicing variants of human type II iodothyronine deiodinase mRNA.	2001 Feb 14	11165050
Measurement of serum concentrations of free thyroxine, total thyroxine, and total triiodothyronine in cats with hyperthyroidism and cats with nonthyroidal disease.	2001 Feb 15	11229503
Thyroid hormone activation in human vascular smooth muscle cells: expression of type II iodothyronine deiodinase.	2001 Feb 16	11179199
Thyroid hormone: targeting the vascular smooth muscle cell.	2001 Feb 16	11179190
Inhibition of T3 production in levothyroxine-treated female mice by the root extract of Convolvulus pluricaulis.	2001 Jan	11280709
Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial.	2001 Jan	11280679
Routine measurement of serum calcitonin is useful for early detection of medullary thyroid carcinoma in patients with nodular thyroid diseases.	2001 Jan	11272100
Endogenous depression, thyroid function and acupuncture.	2001 Jan	11211567
Influence of a high ambient temperature on lipid metabolism in the growing pig.	2001 Jan	11204719
Endocrine relationships of Meishan and White composite females after weaning and during the luteal phase of the estrous cycle.	2001 Jan	11204698
Toxic multinodular goitre in a patient with generalized resistance to thyroid hormone who harbours the R429Q mutation in the thyroid hormone receptor beta gene.	2001 Jan	11167935
Isocaloric carbohydrate deprivation induces protein catabolism despite a low T3-syndrome in healthy men.	2001 Jan	11167929
Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle.	2001 Jan	11133928
Subclinical thyrotoxicosis.	2001 Jan	11123391
Triiodothyronine-mediated up-regulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes.	2001 Jan	11099489
Structure and expression of the transthyretin gene in the choroid plexus: a model for the study of the mechanism of evolution.	2001 Jan 1	11135445
Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element.	2001 Jan 12	11027684
Thyroid hormone deficiency alters extracellular matrix protein expression in rat brain.	2001 Jan 31	11172894
Hormone binding by protein disulfide isomerase, a high capacity hormone reservoir of the endoplasmic reticulum.	2001 Jan 5	11035025
Role of thyroid hormones in hepatic effects of peroxisome proliferators.	2001 Jan-Feb	11215679
Androgen-Dependent transcriptional regulation of the prostate-specific antigen gene by thyroid hormone 3,5,3'-L-triiodothyronine.	2001 Jan-Feb	11191079
An array of positioned nucleosomes potentiates thyroid hormone receptor action in vivo.	2001 Jun 8	11274156
The effects of triiodothyronine augmentation on antithrombin III levels in sepsis.	2001 Mar	11270884
Perioperative considerations in a hypothyroid infant with hepatic haemangioma.	2001 Mar	11240884
Selenium decreases thyroglobulin concentrations but does not affect the increased thyroxine-to-triiodothyronine ratio in children with congenital hypothyroidism.	2001 Mar	11238502
Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebo-controlled study.	2001 Mar	11238494
Homogeneous enzyme immunoassay for triiodothyronine in serum.	2001 Mar	11238313
Distinct tissue-specific roles for thyroid hormone receptors beta and alpha1 in regulation of type 1 deiodinase expression.	2001 Mar	11222747
Hormone selectivity in thyroid hormone receptors.	2001 Mar	11222741
Thyroid hormones regulate pituitary growth hormone secretagogue receptor gene expression.	2001 Mar	11207942
Effects of prolonged fasting on plasma cortisol and TH in postweaned northern elephant seal pups.	2001 Mar	11171659
Insulin-like growth factor binding proteins in femoral and vertebral bone marrow stromal cells: expression and regulation by thyroid hormone and dexamethasone.	2001 Mar 26	11241663
Thyroid hormone promotes serine phosphorylation of p53 by mitogen-activated protein kinase.	2001 Mar 6	11258898
Effect of different drugs on the level of DNA-hydrolyzing polyclonal IgG antibodies in sera of patients with Hashimoto's thyroiditis and nontoxic nodal goiter.	2001 Mar-Apr	11257722
Transcriptional repression by thyroid hormone receptors. A role for receptor homodimers in the recruitment of SMRT corepressor.	2001 May 18	11278601
Slower skeletal muscle phenotypes are critical for constitutive expression of Hsp70 in overloaded rat plantaris muscle.	2006 Mar	16293703

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

The relative affinity of the rat synaptosomes for various T3 analogs was measured by incubating [3H]T3 with increasing amounts of T3, D-T3, T4, TRIAC and rT3, The results were expressed as the molar ratio of the concentrations of T3 or analog needed to decreaseby 50% the binding of [3H]T3.

Substance Class	Chemical Created by `admin` on `Wed Jul 05 23:03:26 UTC 2023` Edited by `admin` on `Wed Jul 05 23:03:26 UTC 2023`
Record UNII	06LU7C9H1V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LIOTHYRONINE

Official Name

English

LIOTHYRONINE [MI]

Common Name

English

LEVOTHYROXINE SODIUM RELATED COMPOUND LIOTHYRONINE [USP IMPURITY]

Common Name

English

CYRONINE

Brand Name

English

T3

Common Name

English

NSC-80203

Code

English

LIOTHYRONINE [USP IMPURITY]

Common Name

English

3,5,3'-TRIIODOTHYRONINE, L-

Common Name

English

LEVOTHYROXINE SODIUM IMPURITY A [EP IMPURITY]

Common Name

English

Liothyronine [WHO-DD]

Common Name

English

LIOTHYRONINE [VANDF]

Common Name

English

O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-L-TYROSINE

Systematic Name

English

3,3',5-TRIIODO-L-THYRONINE

Systematic Name

English

L-TYROSINE, O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-

Systematic Name

English

3,5,3'-TRIIODOTHYRONINE

Systematic Name

English

RATHYRONINE, (S)-

Common Name

English

ALANINE, 3-(4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL)-, L-

Systematic Name

English

T-3

Common Name

English

TRIIODOTHYRONINE

Systematic Name

English

THYRONINE, 3,3',5-TRIIODO-, L-

Systematic Name

English

(2S)-2-AMINO-3-(4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL)PROPANOIC ACID

Systematic Name

English

liothyronine [INN]

Common Name

English

LIOTHYRONINE [HSDB]

Common Name

English

LIOTHYRONINE [USP-RS]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 862.1715