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Details

Stereochemistry ACHIRAL
Molecular Formula C24H16N6
Molecular Weight 388.424
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RIDINILAZOLE

SMILES

N1C2=CC(=CC=C2N=C1C3=CC=NC=C3)C4=CC=C5N=C(NC5=C4)C6=CC=NC=C6

InChI

InChIKey=UHQFBTAJFNVZIV-UHFFFAOYSA-N
InChI=1S/C24H16N6/c1-3-19-21(29-23(27-19)15-5-9-25-10-6-15)13-17(1)18-2-4-20-22(14-18)30-24(28-20)16-7-11-26-12-8-16/h1-14H,(H,27,29)(H,28,30)

HIDE SMILES / InChI

Molecular Formula C24H16N6
Molecular Weight 388.424
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ridinilazole (SMT19969) is a compound that was developed as a treatment for Clostridium difficile infection, which is a spore-forming bacterial infection and the leading cause of infectious healthcare-associated diarrhea. Ridinilazole has a highly targeted spectrum of activity and can spare the normal gut microbiota. A phase I clinical trial demonstrated that oral ridinilazole is well tolerated. A phase II study showed the potential of ridinilazole in treatment of initial Clostridium difficile infection and showed that this drug can reduce recurrence of the disease. In 2019, recruitment for phase III trials was still ongoing.

Approval Year

Substance Class Chemical
Record UNII
06DX01190R
Record Status Validated (UNII)
Record Version