ARC-19499

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Tue Apr 01 16:29:12 GMT 2025` Edited by `admin` on `Tue Apr 01 16:29:12 GMT 2025`
Nucleic Acid Type	APTAMER
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	0493WH50VT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ARC-19499

Common Name

English

ARC19499

Preferred Name

English

BAX499

Code

English

BAX-499

Code

English

RNA, (Gm-Gm-Am-Am-Um-Am-Um-Am-dC-Um-Um-Gm-Gm-dC-Um-dC-Gm-Um-Um-Am-Gm-Gm-Um-Gm-dC-Gm-Um-Am-Um-Am-Um-Am-(3??3?)-dT), 5?-(6-aminohexyl hydrogen phosphate)

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

298409

Created by admin on Tue Apr 01 16:29:12 GMT 2025 , Edited by admin on Tue Apr 01 16:29:12 GMT 2025

Code System Code Type Description

FDA UNII

0493WH50VT

Created by admin on Tue Apr 01 16:29:12 GMT 2025 , Edited by admin on Tue Apr 01 16:29:12 GMT 2025

PRIMARY

SMS_ID

100000183884

Created by admin on Tue Apr 01 16:29:12 GMT 2025 , Edited by admin on Tue Apr 01 16:29:12 GMT 2025

PRIMARY

CAS

1350667-54-7

Created by admin on Tue Apr 01 16:29:12 GMT 2025 , Edited by admin on Tue Apr 01 16:29:12 GMT 2025

PRIMARY

DRUG BANK

DB15285

Created by admin on Tue Apr 01 16:29:12 GMT 2025 , Edited by admin on Tue Apr 01 16:29:12 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_8;1_13;1_18;1_25	4 / 33
2'-O-Methyl-Ribose	1_1-1_7;1_9-1_12;1_14-1_17;1_19-1_24;1_26-1_32	28 / 33
	1_33	1 / 33

Linkage	Site Range	Site Count
Phosphate	1_2-1_33	32 / 32

Related Record Type Details


					1U5PI2DLU1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					0493WH50VT

ARC-19499

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS	G		Y-BRANCHED-M-PEG-40000-HEXYLAMINE-2'METHYL-GUANOSINE	72Q0SQ4X1J