IPRONIDAZOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H11N3O2
Molecular Weight	169.1811
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C1=NC=C(N1C)[N+]([O-])=O

InChI

InChIKey=NTAFJUSDNOSFFY-UHFFFAOYSA-N

InChI=1S/C7H11N3O2/c1-5(2)7-8-4-6(9(7)3)10(11)12/h4-5H,1-3H3

HIDE SMILES / InChI

Molecular Formula	C7H11N3O2
Molecular Weight	169.1811
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.inchem.org/documents/jecfa/jecmono/v25je04.htm | http://www.fao.org/fileadmin/user_upload/vetdrug/docs/41-2-ipronidazole.pdf

Ipronidazole is an antiprotozoal drug of the nitroimidazole class used in veterinary medicine. Ipronidazole (2-isopropyl-1-methyl-5-nitroimidazole) is used for the treatment of histomoniasis in turkeys and in swine dysentery.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histomonas meleagridis 2 Target ID: Histomonas meleagridis Sources: http://www.fao.org/fileadmin/user_upload/vetdrug/docs/41-2-ipronidazole.pdf \| https://getd.libs.uga.edu/pdfs/hu_jinghui_200212_phd.pdf	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Histomoniasis 7 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4797959 https://www.ncbi.nlm.nih.gov/pubmed/4674999	Curative		Approved 8583	Ipropran Approved Use Ipronidazole is used in turkeys (l) for the prevention and treatment of blackhead (histomoniasis)

PubMed

Title	Date	PubMed
Validation of a method for the detection and confirmation of nitroimidazoles and corresponding hydroxy metabolites in turkey and swine muscle by means of gas chromatography-negative ion chemical ionization mass spectrometry.	2001-09-15	11585131

Patents

Sample Use Guides

In Vivo Use Guide

Ipronidazole is administered through the feed at levels of approximately 0.006253% (prevention) to 0.025% (treatment). Continuous feeding of ipronidazole at a concentration of 100 g/ton in feed has been shown to prevent swine dysentery. Administration of ipronidazole at 200 to 800 mg/gal of drinking water for 7 days was effective in treating swine dysentery.

Route of Administration: Oral

In Vitro Use Guide

2.3 uM/mg protein of Ipronidazole induced a 60% decrease in rabbit heart mitochondrial ADP-stimulated oxygen uptake using glutamate-malate as substrate.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:56:47 GMT 2025` Edited by `admin` on `Mon Mar 31 17:56:47 GMT 2025`
Record UNII	045BU63E23
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IPRONIDAZOLE

Official Name

English

NSC-109212

Preferred Name

English

RO 7-1554

Code

English

IPRONIDAZOLE [GREEN BOOK]

Common Name

English

2-Isopropyl-1-methyl-5-nitroimidazole

Systematic Name

English

RO-7-1554

Code

English

ipronidazole [INN]

Common Name

English

IPRONIDAZOLE [MI]

Common Name

English

IPRONIDAZOLE [MART.]

Common Name

English

1H-IMIDAZOLE, 1-METHYL-2-(1-METHYLETHYL)-5-NITRO-

Systematic Name

English

RO-71554

Code

English

IPRONIDAZOLE [USAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QP51AA10