U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Indium In-111 pentetate disodium is a radioactive diagnostic indicated for use in radionuclide cisternography. Decay of In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and spinal column. Indium In 111 pentetate ( 111In-DTPA) is indicated as an imaging agent in cisternography to study the flow of cerebrospinal fluid (CSF) in the brain, to diagnose abnormalities in CSF circulation, to assess and help localize the site of CSF leakage, and to test the patency of or localize blocks in CSF shunts.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
MPI INDIUM DTPA IN 111

Approved Use

Unknown

Launch Date

1982
Diagnostic
MPI INDIUM DTPA IN 111

Approved Use

Unknown

Launch Date

1982
Diagnostic
MPI INDIUM DTPA IN 111

Approved Use

Unknown

Launch Date

1982

Sample Use Guides

The maximum recommended intrathecal dose in the average patient (70 kg) is 18.5 MBq, 500 μCi. The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.
Route of Administration: Other
Substance Class Protein
Created
by admin
on Mon Mar 31 23:03:29 GMT 2025
Edited
by admin
on Mon Mar 31 23:03:29 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1
Sequence Origin MOUSE
Sequence Type COMPLETE
Record UNII
03MZ53X1YS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
INDIUM IN-111 CAPROMAB PENDETIDE
Common Name English
INDIUM IN 111 CAPROMAB PENDETIDE
VANDF  
Preferred Name English
INDIUM (111IN) CAPROMAB PENDETIDE
Common Name English
(SUP 111)IN-CAPROMAB PENDETIDE
Common Name English
INDIUM IN-111 PROSTASCINT
Brand Name English
CYT-351
Code English
PROSTASCINT INDIUM IN-111
Brand Name English
INDIUM IN 111 CAPROMAB PENDETIDE [VANDF]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2124
Created by admin on Mon Mar 31 23:03:29 GMT 2025 , Edited by admin on Mon Mar 31 23:03:29 GMT 2025
WHO-ATC V09IB04
Created by admin on Mon Mar 31 23:03:29 GMT 2025 , Edited by admin on Mon Mar 31 23:03:29 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C88292
Created by admin on Mon Mar 31 23:03:29 GMT 2025 , Edited by admin on Mon Mar 31 23:03:29 GMT 2025
PRIMARY NCIT
ChEMBL
CHEMBL2108800
Created by admin on Mon Mar 31 23:03:29 GMT 2025 , Edited by admin on Mon Mar 31 23:03:29 GMT 2025
PRIMARY
FDA UNII
03MZ53X1YS
Created by admin on Mon Mar 31 23:03:29 GMT 2025 , Edited by admin on Mon Mar 31 23:03:29 GMT 2025
PRIMARY
Related Record Type Details
ACTIVE MOIETY
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
OXIDIZES SUGAR OXIDIZER SODIUM METAPERIODATE 98W4A29X43
CHELATING AGENT CONJUGATION SODIUM METAPERIODATE 98W4A29X43

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
MOIETY SUGAR Amount: INDIUM CATION IN-111 WJZ06C0H8L
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL